2
MH 701 Final Exam with precise detailed answers
|| || || || || || ||
How is the amygdala involved in the production of anxiety?
|| || || || || || || || ||
1. Produces sustained response
|| || ||
2. Part of the Limbic system, which is responsible for emotional expression, memory,
|| || || || || || || || || || || || ||
learning, & motivation || ||
3. attaching significance to stimuli
|| || || ||
What are the neurotransmitters involved in depression?
|| || || || || ||
Serotonin (low) ||
Dopamine (low) ||
Norepinephrine (low) ||
*critical for mood regulation || || ||
What neurotransmitters are involved in 1st gen & 2nd gen antipsychotics?
|| || || || || || || || || ||
1st: Dopamine
||
2nd: Dopamine & Serotonin (broader therapeutic effect)
|| || || || || ||
What do 1st gen antipsychotics block?
|| || || || ||
BLOCK D2 receptors- reduces dopaminergic activity which is linked to antipsych symptoms
|| || || || || || || || || || ||
,2
What are inducers?
|| ||
substance that increases metabolism which decreases another substances serum levels &
|| || || || || || || || || || ||
efficacy
What is pharmacodynamics? What is pharmacokinetics?
|| || || || ||
D: what the drug does to the body
|| || || || || || ||
K: what they body does to the drug (metabolize/eliminate)
|| || || || || || || ||
What is a common mistake leading to an unsuccessful antidepressant drug trial?
|| || || || || || || || || || ||
Too low dosage for too short of a time
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What is the Black Box Warning for antidepressants?
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risk of suicidality (*especially in younger patients=careful monitoring)
|| || || || || || ||
What is something to educate patients about in terms of antidepressants?
|| || || || || || || || || ||
Expected timeline for antidepressants effects is 4-6 weeks which manages patient
|| || || || || || || || || || ||
expectations.
What is the MOA of SSRI's & SNRI's?
|| || || || || || ||
they inhibit the reuptake of S & NE, this increases their availability in the synaptic cleft.
|| || || || || || || || || || || || || || ||
, 2
What is discontinuation syndrome?
|| || ||
Occurs with abrupt cessation of SSRI's, characterized by flu-like symptoms & irritability
|| || || || || || || || || || ||
*drugs with short-half life
|| || ||
Which SSRI is associated with the highest risk of discontinuation syndrome?
|| || || || || || || || || ||
Paroxetine
Which SSRI has an indication for the Tx of bulimia to decrease binging patterns?
|| || || || || || || || || || || || ||
Fluoxetine (*FDA approved) || ||
What sexual side effects can SSRIs cause? What are possible interventions?
|| || || || || || || || || ||
decreased libido / Bupropion || || ||
Which of the SSRI's is highest risk of drug to drug interactions d/t CYP enzymes?
|| || || || || || || || || || || || || ||
fluoxetine, fluoxetine, & paroxetine || || ||
What is the MOA of TCAs?
|| || || || ||
Block NE and serotonin transporter site = increased NE & S in synaptic cleft
|| || || || || || || || || || || || ||
MH 701 Final Exam with precise detailed answers
|| || || || || || ||
How is the amygdala involved in the production of anxiety?
|| || || || || || || || ||
1. Produces sustained response
|| || ||
2. Part of the Limbic system, which is responsible for emotional expression, memory,
|| || || || || || || || || || || || ||
learning, & motivation || ||
3. attaching significance to stimuli
|| || || ||
What are the neurotransmitters involved in depression?
|| || || || || ||
Serotonin (low) ||
Dopamine (low) ||
Norepinephrine (low) ||
*critical for mood regulation || || ||
What neurotransmitters are involved in 1st gen & 2nd gen antipsychotics?
|| || || || || || || || || ||
1st: Dopamine
||
2nd: Dopamine & Serotonin (broader therapeutic effect)
|| || || || || ||
What do 1st gen antipsychotics block?
|| || || || ||
BLOCK D2 receptors- reduces dopaminergic activity which is linked to antipsych symptoms
|| || || || || || || || || || ||
,2
What are inducers?
|| ||
substance that increases metabolism which decreases another substances serum levels &
|| || || || || || || || || || ||
efficacy
What is pharmacodynamics? What is pharmacokinetics?
|| || || || ||
D: what the drug does to the body
|| || || || || || ||
K: what they body does to the drug (metabolize/eliminate)
|| || || || || || || ||
What is a common mistake leading to an unsuccessful antidepressant drug trial?
|| || || || || || || || || || ||
Too low dosage for too short of a time
|| || || || || || || ||
What is the Black Box Warning for antidepressants?
|| || || || || || ||
risk of suicidality (*especially in younger patients=careful monitoring)
|| || || || || || ||
What is something to educate patients about in terms of antidepressants?
|| || || || || || || || || ||
Expected timeline for antidepressants effects is 4-6 weeks which manages patient
|| || || || || || || || || || ||
expectations.
What is the MOA of SSRI's & SNRI's?
|| || || || || || ||
they inhibit the reuptake of S & NE, this increases their availability in the synaptic cleft.
|| || || || || || || || || || || || || || ||
, 2
What is discontinuation syndrome?
|| || ||
Occurs with abrupt cessation of SSRI's, characterized by flu-like symptoms & irritability
|| || || || || || || || || || ||
*drugs with short-half life
|| || ||
Which SSRI is associated with the highest risk of discontinuation syndrome?
|| || || || || || || || || ||
Paroxetine
Which SSRI has an indication for the Tx of bulimia to decrease binging patterns?
|| || || || || || || || || || || || ||
Fluoxetine (*FDA approved) || ||
What sexual side effects can SSRIs cause? What are possible interventions?
|| || || || || || || || || ||
decreased libido / Bupropion || || ||
Which of the SSRI's is highest risk of drug to drug interactions d/t CYP enzymes?
|| || || || || || || || || || || || || ||
fluoxetine, fluoxetine, & paroxetine || || ||
What is the MOA of TCAs?
|| || || || ||
Block NE and serotonin transporter site = increased NE & S in synaptic cleft
|| || || || || || || || || || || || ||
