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ATI RN Adult Medical Surgical Practice Exam 2026 Update: 200+ NGN-Style Questions with Rationales | NCLEX Prep

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Pass the ATI RN Adult Medical Surgical proctored exam and the Next Generation NCLEX (NGN) with this updated 2026 practice test bank. This comprehensive resource features over 200 high-yield multiple-choice and NGN-style questions (matrix, drag-and-drop, unfolding case studies) with detailed rationales for correct and incorrect answers. Content covers all major medical-surgical topics tested on ATI and NCLEX: Cardiovascular Disorders (HF, MI, A-fib, PAD, cardiac cath, pacemakers) Respiratory Disorders (COPD, pneumonia, PE, TB, chest tubes, mechanical ventilation) Endocrine Disorders (DKA, HHNS, thyroid disorders, SIADH, diabetes insipidus, adrenal disorders) Gastrointestinal Disorders (cirrhosis, pancreatitis, IBD, ostomies, GERD, hepatitis) Renal & Urinary Disorders (CKD, AKI, dialysis, kidney stones, UTI) Neurological Disorders (stroke, seizures, Parkinson's, meningitis, Guillain-Barré, head injury) Musculoskeletal & Hematologic Disorders (hip arthroplasty, osteoporosis, sickle cell, ITP, hemophilia) Pharmacology & Medication Administration (anticoagulants, insulin, diuretics, antibiotics, pain management) Each question includes the correct answer, rationale, and nursing priority actions. Updated for 2026 ATI guidelines and NGN clinical judgment measurement model. Perfect for nursing students preparing for ATI proctored exams, NCLEX-RN, and medical-surgical course finals.

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ATI RN ADULT MEDICAL SURGICAL PRACTICE
EXAM 2026 UPDATE NEXT GENERATION NCLEX
(NGN) STYLE – 200+ QUESTIONS WITH
RATIONALES



Section 1: Cardiovascular Disorders (Questions 1-25)


### Standard Multiple Choice


**1. A nurse is assessing a client who is 12 hours postoperative
following a cardiac catheterization via the right femoral artery. Which of
the following findings requires immediate intervention?**
- A) Blood pressure 128/74 mm Hg
- B) Heart rate 86/min
- C) A small amount of bloody drainage on the dressing
- D) A palpable, hard lump at the catheter insertion site


**Answer: D) A palpable, hard lump at the catheter insertion site**


*Rationale:* A palpable, hard lump (hematoma) at the insertion site
indicates active bleeding into the tissue, which can lead to compromised
circulation to the limb and significant blood loss. The nurse should

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immediately apply firm pressure proximal to the site, assess distal
pulses, and notify the provider. Small amounts of drainage are expected.


---


**2. A client with acute decompensated heart failure has an ejection
fraction of 25% and presents with severe dyspnea and crackles in all
lung fields. Which medication does the nurse expect to administer
first?**
- A) Digoxin
- B) Furosemide IV
- C) Carvedilol
- D) Spironolactone


**Answer: B) Furosemide IV**


*Rationale:* IV furosemide rapidly reduces preload, relieving
pulmonary edema. Beta-blockers (carvedilol) are for chronic HF
management, not acute decompensation. Digoxin and spironolactone are
not first-line for acute pulmonary edema.


---

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**3. A client with atrial fibrillation is prescribed warfarin. Which INR
value indicates a therapeutic range for this client?**
- A) 1.5
- B) 2.5
- C) 3.8
- D) 4.5


**Answer: B) 2.5**


*Rationale:* Target INR for atrial fibrillation is 2-3. An INR of 1.5 is
subtherapeutic and increases stroke risk. An INR >4 increases bleeding
risk.


---


**4. A client with an acute STEMI reports chest pain unrelieved by three
sublingual nitroglycerin tablets. Which medication should the nurse
prepare to administer?**
- A) Morphine sulfate
- B) Aspirin
- C) Metoprolol
- D) Heparin

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**Answer: A) Morphine sulfate**


*Rationale:* Morphine reduces pain and preload, decreasing myocardial
oxygen demand. Aspirin should already have been given on arrival.
Heparin and metoprolol do not provide acute pain relief.


---


**5. A nurse is providing discharge teaching to a client who has a new
prescription for sublingual nitroglycerin. Which client statement
indicates understanding of the teaching?**
- A) "I can keep my medications for 1 year before replacing it."
- B) "I should lie down when I take this medication."
- C) "I should discontinue this medication if I develop a headache."
- D) "I can take up to five tablets in 15 minutes before seeking medical
attention."


**Answer: B) "I should lie down when I take this medication."**


*Rationale:* Nitroglycerin causes vasodilation and can lead to
hypotension and dizziness. Lying down helps prevent injury from falls.
Headache is an expected side effect and not a reason to discontinue.
Nitroglycerin should be replaced every 6 months. The correct dosing is
one tablet every 5 minutes for up to 3 doses; if pain persists, seek
emergency care.

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