NURS 6635 FINAL EXAM WINTER 2026 TEST
PAPER PRACTICE QUESTIONS AND
SOLUTIONS FULL REVIEW A+
◉ The disorder manifests when a person with a genetic
predisposition is exposed to one of many environmental stressors.
- genetic predisposition
- environmental stressors Answer: Etiological factors of
schizophrenia
◉ Environmental stressors are believed to be triggers of
schizophrenia rather than true causes of the disorder.
-Childhood trauma
- Residence in an urban area
- Social isolation
-Frequent cannabis use in early adolescence
- Migration
- Poverty
- Stress and psychosocial factors
- Birth in late winter or early spring
-Advanced paternal age at conception Answer: Environmental
Stressors of Schizophrenia
, ◉ Genetic and environmental risk factors appear to act via a
common pathway
of disrupting the function of 1 or more neurotransmitter
components.
Dopaminergic theory: Almost all drugs with antipsychotic
properties block the dopaminergic D2 receptor.
However, antipsychotics are only 70% effective and clozapine, the
most effective antipsychotic for treating schizophrenia, is a weak D2
antagonist.
Hyperactivity of dopamine D2 receptor neurotransmission in
subcortical, and limbic brain regions contribute to the positive
symptoms of schizophrenia. Hypo functionality of dopamine D1
receptor neurotransmission in the prefrontal cortex contributes to
both negative and cognitive symptoms. Answer: Pathophysiology of
schizophrenia part 1
◉ Other theories:
Hypofunction of the N-methyl-D-aspartate (NMDA) glutamate
receptor. Dysfunctional gamma-amino-butyric acid (GABA)
interneurons.
Dysfunctional nicotinic acetylcholine receptors. Answer:
Pathophysiology of schizophrenia part 2
PAPER PRACTICE QUESTIONS AND
SOLUTIONS FULL REVIEW A+
◉ The disorder manifests when a person with a genetic
predisposition is exposed to one of many environmental stressors.
- genetic predisposition
- environmental stressors Answer: Etiological factors of
schizophrenia
◉ Environmental stressors are believed to be triggers of
schizophrenia rather than true causes of the disorder.
-Childhood trauma
- Residence in an urban area
- Social isolation
-Frequent cannabis use in early adolescence
- Migration
- Poverty
- Stress and psychosocial factors
- Birth in late winter or early spring
-Advanced paternal age at conception Answer: Environmental
Stressors of Schizophrenia
, ◉ Genetic and environmental risk factors appear to act via a
common pathway
of disrupting the function of 1 or more neurotransmitter
components.
Dopaminergic theory: Almost all drugs with antipsychotic
properties block the dopaminergic D2 receptor.
However, antipsychotics are only 70% effective and clozapine, the
most effective antipsychotic for treating schizophrenia, is a weak D2
antagonist.
Hyperactivity of dopamine D2 receptor neurotransmission in
subcortical, and limbic brain regions contribute to the positive
symptoms of schizophrenia. Hypo functionality of dopamine D1
receptor neurotransmission in the prefrontal cortex contributes to
both negative and cognitive symptoms. Answer: Pathophysiology of
schizophrenia part 1
◉ Other theories:
Hypofunction of the N-methyl-D-aspartate (NMDA) glutamate
receptor. Dysfunctional gamma-amino-butyric acid (GABA)
interneurons.
Dysfunctional nicotinic acetylcholine receptors. Answer:
Pathophysiology of schizophrenia part 2
