CPHON Chemo Chart And Late Effects
Exam UPDATED QUESTIONS AND
CORRECT ANSWERS
Which chemo(s) cause late cognitive effects - CORRECT ANSWER Methotrexate, Cytarabine,
Dexamethasone
Chemo agents causing peripheral neuropathies - CORRECT ANSWER Vincristine
Vinblastine
Etop
Cisplatin
Ototoxic chemo agents - CORRECT ANSWER Cisplatin*
Ifosfamide
Carboplatin
Long term use of _____ is associated with the development of cataracts - CORRECT
ANSWER corticosteroids
Chemo agents causing late effects on cardiac - CORRECT ANSWER Anthracyclines:
doxorubicin, daunorubicin, idarubicin - all damage the myocytes of the heart and cause
cardiomyopathy
Cyclophosphamide (Cytoxan) may cause left ventricular damage and may exacerbate cardiomyopathy
when given in conjunction with anthracyclines
Chemo agents causing late effects on pulmonary system - CORRECT ANSWER Nitrosureas -
lomustine and carmustine
HD cyclophosphamide
Busulfan
Bleomycin
,What are the most common long term pathologic long term effects of the GI tract from chemo -
CORRECT ANSWER Fibrosis and enteritis
Most common long term abnormalities of the liver in long term survivors from chemo - CORRECT
ANSWER fibrosis and cirrhosis
Survivors of _________ and _______ are most at risk for hepatic late effects - CORRECT
ANSWER leukemia and HSCT
What 2 chemos can enhance hepatic effects - CORRECT ANSWER dactinomycin and
doxorubicin
Which 3 chemos have been associated with liver damage leading to liver fibrosis - CORRECT
ANSWER Methotrexate
6MP
Thioguanine
Which 3 chemos are associated with long term renal complications - CORRECT
ANSWER Cisplatin
Ifosfamide
Carboplatin
What is the primary hematopoetic late effect from chemo - CORRECT ANSWER compromised
bone marow function secondary to myelosuppressive chemotherapy
Examples of endocrine late effects from chemo - CORRECT ANSWER growth delay
Weight problems
Diabetes
Precocious or delayed puberty
Gonadal dysfunction
Thyroid dysfunction
Adrenal dysfunction
, Patients treated with which 2 chemos are at greatest risk developing endocrinopathies - CORRECT
ANSWER Alkylating agents and corticosteroids
Alkalating agents may affect both the male and female reproductive systems, examples of these late
effects are: - CORRECT ANSWER abnormal hormone function
Delayed or absent puberty
Subfertility or infertility
Early menopause in young women
What 2 MSK diagnoses can occur with prolonged use of corticosteroids - CORRECT
ANSWER osteopenia and osteoporosis
Corticosteroids such as pred and dex can cause bone loss by decreasing osteoblast activity, shortening
the life span of the osteoblasts and increasing bone resorption
Avascular necrosis (osteonecrosis) is a well known complication of use of - CORRECT
ANSWER corticosteroids
What antimetabolite is implicated in bone loss - CORRECT ANSWER methotrexate
It inhibits osteoblast proliferation
Which chemo agents are linked to later development of AML and myelodysplastic syndrome (MDS) -
CORRECT ANSWER Alkylating agents and epipodophyllotoxins such as etoposide and
teniposide
Doxorubicin has been linked to secondary ______ - CORRECT ANSWER leukemias
What 2 chemo agents have been linked to the development of bladder cancer - CORRECT
ANSWER Cyclophosfamide and Ifosfamide
2 chemos in the antibiotic class - CORRECT ANSWER Bleomycin sulfate
Dactinomycin
Exam UPDATED QUESTIONS AND
CORRECT ANSWERS
Which chemo(s) cause late cognitive effects - CORRECT ANSWER Methotrexate, Cytarabine,
Dexamethasone
Chemo agents causing peripheral neuropathies - CORRECT ANSWER Vincristine
Vinblastine
Etop
Cisplatin
Ototoxic chemo agents - CORRECT ANSWER Cisplatin*
Ifosfamide
Carboplatin
Long term use of _____ is associated with the development of cataracts - CORRECT
ANSWER corticosteroids
Chemo agents causing late effects on cardiac - CORRECT ANSWER Anthracyclines:
doxorubicin, daunorubicin, idarubicin - all damage the myocytes of the heart and cause
cardiomyopathy
Cyclophosphamide (Cytoxan) may cause left ventricular damage and may exacerbate cardiomyopathy
when given in conjunction with anthracyclines
Chemo agents causing late effects on pulmonary system - CORRECT ANSWER Nitrosureas -
lomustine and carmustine
HD cyclophosphamide
Busulfan
Bleomycin
,What are the most common long term pathologic long term effects of the GI tract from chemo -
CORRECT ANSWER Fibrosis and enteritis
Most common long term abnormalities of the liver in long term survivors from chemo - CORRECT
ANSWER fibrosis and cirrhosis
Survivors of _________ and _______ are most at risk for hepatic late effects - CORRECT
ANSWER leukemia and HSCT
What 2 chemos can enhance hepatic effects - CORRECT ANSWER dactinomycin and
doxorubicin
Which 3 chemos have been associated with liver damage leading to liver fibrosis - CORRECT
ANSWER Methotrexate
6MP
Thioguanine
Which 3 chemos are associated with long term renal complications - CORRECT
ANSWER Cisplatin
Ifosfamide
Carboplatin
What is the primary hematopoetic late effect from chemo - CORRECT ANSWER compromised
bone marow function secondary to myelosuppressive chemotherapy
Examples of endocrine late effects from chemo - CORRECT ANSWER growth delay
Weight problems
Diabetes
Precocious or delayed puberty
Gonadal dysfunction
Thyroid dysfunction
Adrenal dysfunction
, Patients treated with which 2 chemos are at greatest risk developing endocrinopathies - CORRECT
ANSWER Alkylating agents and corticosteroids
Alkalating agents may affect both the male and female reproductive systems, examples of these late
effects are: - CORRECT ANSWER abnormal hormone function
Delayed or absent puberty
Subfertility or infertility
Early menopause in young women
What 2 MSK diagnoses can occur with prolonged use of corticosteroids - CORRECT
ANSWER osteopenia and osteoporosis
Corticosteroids such as pred and dex can cause bone loss by decreasing osteoblast activity, shortening
the life span of the osteoblasts and increasing bone resorption
Avascular necrosis (osteonecrosis) is a well known complication of use of - CORRECT
ANSWER corticosteroids
What antimetabolite is implicated in bone loss - CORRECT ANSWER methotrexate
It inhibits osteoblast proliferation
Which chemo agents are linked to later development of AML and myelodysplastic syndrome (MDS) -
CORRECT ANSWER Alkylating agents and epipodophyllotoxins such as etoposide and
teniposide
Doxorubicin has been linked to secondary ______ - CORRECT ANSWER leukemias
What 2 chemo agents have been linked to the development of bladder cancer - CORRECT
ANSWER Cyclophosfamide and Ifosfamide
2 chemos in the antibiotic class - CORRECT ANSWER Bleomycin sulfate
Dactinomycin
