1|Page
UNE (University Of New England) Medical
Biochemistry Final Verified Exam (2 LATEST
VERSIONS)
VERSION A||NEWEST EXAM!!!
Which of the following is the regulatory enzyme for fatty
acid synthesis?
Acetyl-CoA carboxylase
Citrate lyase
Malic enzyme
Fatty acid synthase - ANSWER-Acetyl-CoA carboxylase
Which of the following is the regulated step of lipogenesis
in eukaryotes?
Conversion of cytosolic oxaloacetate to malate
Transportation of mitochondrial acetyl-CoA into the cytosol
Assembly of the fatty acid chain
Carboxylation of acetyl-CoA - ANSWER-Carboxylation of
acetyl-CoA
,2|Page
Which of the following enzymes generates NADPH?
Pyruvate Carboxylase
Acetyl-CoA carboxylase
Malic enzyme
Citrate lyase
Pyruvate dehydrogenase - ANSWER-Malic enzyme
During fatty acid synthesis, after the initial step involving
acetyl-CoA, the fatty acid chain is elongated by the
addition of which of the following compounds?
Succinyl-CoA
Acetyl-CoA
Acyl-CoA
Malonyl-CoA - ANSWER-Malonyl-CoA
Which of the following lipoproteins illustrated below is
most consistent with an LDL?
1
2
,3|Page
3
4 - ANSWER-3
Which of the following enzymes is responsible for
transferring triacylglycerol from VLDL to HDL in exchange
for cholesterol?
Microsomal transfer protein
CEPT (Cholesteryl ester transfer protein)
Phosphatidylcholine:cholesterol acyltransferase (PCAT,
aka LCAT)
Lipoprotein Lipase - ANSWER-CEPT (Cholesteryl ester
transfer protein)
Cholesterol stimulates the activity of which of the following
proteins required for bile acid synthesis?
12 α-hydroxylase
Cholesterol esterase
7 α-hydroxylase
HMG-CoA Reductase - ANSWER-7 α-hydroxylase
, 4|Page
Cushing syndrome is caused by an increase in the
synthesis of cortisol in the adrenal gland. Which of the
following compounds is the substrate for the synthesis of
this hormone?
Amino acids
Cholesterol
Free fatty acids
Glucose - ANSWER-Cholesterol
Which of the following is the regulatory enzyme in
cholesterol synthesis?
HMG-CoA synthase
HMG-CoA reductase
Acetyl CoA carboxylase
Carnitine palmitoyl transferase I (CPTI) - ANSWER-HMG-
CoA reductase
Ketogenesis is regulated by the rate of several other
processes. Which of the following would decrease the rate
of ketone body synthesis?
Increased flux through the TCA cycle.
UNE (University Of New England) Medical
Biochemistry Final Verified Exam (2 LATEST
VERSIONS)
VERSION A||NEWEST EXAM!!!
Which of the following is the regulatory enzyme for fatty
acid synthesis?
Acetyl-CoA carboxylase
Citrate lyase
Malic enzyme
Fatty acid synthase - ANSWER-Acetyl-CoA carboxylase
Which of the following is the regulated step of lipogenesis
in eukaryotes?
Conversion of cytosolic oxaloacetate to malate
Transportation of mitochondrial acetyl-CoA into the cytosol
Assembly of the fatty acid chain
Carboxylation of acetyl-CoA - ANSWER-Carboxylation of
acetyl-CoA
,2|Page
Which of the following enzymes generates NADPH?
Pyruvate Carboxylase
Acetyl-CoA carboxylase
Malic enzyme
Citrate lyase
Pyruvate dehydrogenase - ANSWER-Malic enzyme
During fatty acid synthesis, after the initial step involving
acetyl-CoA, the fatty acid chain is elongated by the
addition of which of the following compounds?
Succinyl-CoA
Acetyl-CoA
Acyl-CoA
Malonyl-CoA - ANSWER-Malonyl-CoA
Which of the following lipoproteins illustrated below is
most consistent with an LDL?
1
2
,3|Page
3
4 - ANSWER-3
Which of the following enzymes is responsible for
transferring triacylglycerol from VLDL to HDL in exchange
for cholesterol?
Microsomal transfer protein
CEPT (Cholesteryl ester transfer protein)
Phosphatidylcholine:cholesterol acyltransferase (PCAT,
aka LCAT)
Lipoprotein Lipase - ANSWER-CEPT (Cholesteryl ester
transfer protein)
Cholesterol stimulates the activity of which of the following
proteins required for bile acid synthesis?
12 α-hydroxylase
Cholesterol esterase
7 α-hydroxylase
HMG-CoA Reductase - ANSWER-7 α-hydroxylase
, 4|Page
Cushing syndrome is caused by an increase in the
synthesis of cortisol in the adrenal gland. Which of the
following compounds is the substrate for the synthesis of
this hormone?
Amino acids
Cholesterol
Free fatty acids
Glucose - ANSWER-Cholesterol
Which of the following is the regulatory enzyme in
cholesterol synthesis?
HMG-CoA synthase
HMG-CoA reductase
Acetyl CoA carboxylase
Carnitine palmitoyl transferase I (CPTI) - ANSWER-HMG-
CoA reductase
Ketogenesis is regulated by the rate of several other
processes. Which of the following would decrease the rate
of ketone body synthesis?
Increased flux through the TCA cycle.
