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NBME PATHOLOGY FINAL TEST BANK EXAM LATEST 2026-2027
ACTUAL EXAM WITH COMPLETE QUESTIONS AND CORRECT
DETAILED ANSWERS (100% VERIFIED ANSWERS) |ALREADY
GRADED A+| ||PROFESSOR VERIFIED|| ||BRANDNEW!!!||
Describe Acute Megakaryoblastic Leukemia - ANSWER-
Proliferation of Megakaryoblasts that lack MPO.
Seen in downs syndrome before age 5.
Describe Chronic Leukemia - ANSWER-Neoplastic proliferation of
mature lymphocytes characterized by elevated WBC count.
What is the most common leukemia? - ANSWER-Chronic
Lymphocytic Leukemia (CLL)
Describe CLL - ANSWER-Neoplastic proliferation of naive B-cells
that co-express CD5 and CD20
Hypogammaglobulinemia occurs, most patients die of infection.
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Transformation to DLBCL (richter transformation)
Describe Hairy Cell Leukemia - ANSWER-Neoplastic proliferation
of mature B cells with hairy cytoplasmic processes with positive
Tartrate-resistant acid phosphatase (TRAP)
"Dry tap" on marrow aspirate. Splenomegaly.
Describe Adult T-cell Leukemia/Lymphoma - ANSWER-Neoplastic
proliferation of mature CD4 T-cells
Associated with HTLV-1 infection
Rash, lymphadenopathy, HSM, Lytic bone lesions.
Describe mycosis fungoides - ANSWER-Neoplastic proliferation
of mature CD4 cells within the skin. Presents as skin rash/plaques
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Invasion of blood = Sezary Syndrome (lymphocytes w/cerebriform
nuclei in blood)
Describe Chronic Myeloid Leukemia - ANSWER-Mature myeloid
cells, basophilia, splenomegaly
t(9;22) mutation → BCR-ABL
fusion. Treat with imatinib
Can transform to AML or ALL (splenomegaly indicates
transformation imminent)
Describe Polycythemia vera - ANSWER-Neoplastic proliferation of
RBCs and Platelets.
Associated with JAK2 mutation
Hyperviscosisty → blurry vision/headache, venous thrombosis,
flushing, itching
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Low EPO levels and SaO2 is normal
Describe Essential thrombocytopenia - ANSWER-Neoplastic
proliferation of mature myeloid cells, particularly platelets.
Associated with JAK2 mutation.
Risk of bleeding / thrombosis
Describe Myelofibrosis - ANSWER-Neoplasia of mature myeloid
cells d/t JAK2 Kinase mutation.
PDGF from megakaryocytes induces fibrosis of the marrow.
Splenomegaly, Teat-drop RBCs, nucleated RBCs.
Risk of infection and bleeds.
NBME PATHOLOGY FINAL TEST BANK EXAM LATEST 2026-2027
ACTUAL EXAM WITH COMPLETE QUESTIONS AND CORRECT
DETAILED ANSWERS (100% VERIFIED ANSWERS) |ALREADY
GRADED A+| ||PROFESSOR VERIFIED|| ||BRANDNEW!!!||
Describe Acute Megakaryoblastic Leukemia - ANSWER-
Proliferation of Megakaryoblasts that lack MPO.
Seen in downs syndrome before age 5.
Describe Chronic Leukemia - ANSWER-Neoplastic proliferation of
mature lymphocytes characterized by elevated WBC count.
What is the most common leukemia? - ANSWER-Chronic
Lymphocytic Leukemia (CLL)
Describe CLL - ANSWER-Neoplastic proliferation of naive B-cells
that co-express CD5 and CD20
Hypogammaglobulinemia occurs, most patients die of infection.
,2|Page
Transformation to DLBCL (richter transformation)
Describe Hairy Cell Leukemia - ANSWER-Neoplastic proliferation
of mature B cells with hairy cytoplasmic processes with positive
Tartrate-resistant acid phosphatase (TRAP)
"Dry tap" on marrow aspirate. Splenomegaly.
Describe Adult T-cell Leukemia/Lymphoma - ANSWER-Neoplastic
proliferation of mature CD4 T-cells
Associated with HTLV-1 infection
Rash, lymphadenopathy, HSM, Lytic bone lesions.
Describe mycosis fungoides - ANSWER-Neoplastic proliferation
of mature CD4 cells within the skin. Presents as skin rash/plaques
,3|Page
Invasion of blood = Sezary Syndrome (lymphocytes w/cerebriform
nuclei in blood)
Describe Chronic Myeloid Leukemia - ANSWER-Mature myeloid
cells, basophilia, splenomegaly
t(9;22) mutation → BCR-ABL
fusion. Treat with imatinib
Can transform to AML or ALL (splenomegaly indicates
transformation imminent)
Describe Polycythemia vera - ANSWER-Neoplastic proliferation of
RBCs and Platelets.
Associated with JAK2 mutation
Hyperviscosisty → blurry vision/headache, venous thrombosis,
flushing, itching
, 4|Page
Low EPO levels and SaO2 is normal
Describe Essential thrombocytopenia - ANSWER-Neoplastic
proliferation of mature myeloid cells, particularly platelets.
Associated with JAK2 mutation.
Risk of bleeding / thrombosis
Describe Myelofibrosis - ANSWER-Neoplasia of mature myeloid
cells d/t JAK2 Kinase mutation.
PDGF from megakaryocytes induces fibrosis of the marrow.
Splenomegaly, Teat-drop RBCs, nucleated RBCs.
Risk of infection and bleeds.
