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ankylosing spondylitis an inflammatory disorder of the spine that can also
involve the peripheral joints. Diagnosis is usually
based on clinical features, including loss of spinal
spinal motion, decreased chest expansion, and
inflammatory back pain.
reactive arthritis typically begins after an acute diarrheal illness
caused by various bacteria. This form of seronegative
arthritis is more common in men. Alternatively, it can
begin after a venereal infection, such as chlamydia.
The classic triad of reactive
arthritis is:
1. arthritis - tends to be an asymmetric oligoarthritis
of lower extremity joints and can also
involve the spine, similarly to ankylosing spondylitis
2. urethritis
3. conjunctivitis.
polyarteritis nodosa characterized by inflammation in the
walls of blood vessels of various sizes. PAN is one
example of a disorder linked to hepatitis B infection
in many
cases.
Raynaud's phenomenon refers to the paroxysmal pallor or cyanosis of the
digits of the hands and feet where body temperature
is at its lowest
types of vasculitis polyarteritis nodosa, Wegener's granulomatosis,
temporal arteritis
, polyarteritis nodosa is a prime example of a medium vessel vasculitis
(MVV)affecting the arteries that contain muscular
walls. The damage caused by the inflammation leads
to aneurysmal formation.
Wegener's granulomatosis a vasculitis of the small and medium vessels, affects
approximately one in 20,000-30,000 people. WG
affects primarily the lungs and kidneys but is not
overtly apparent early in the course of the disease.
temporal arteritis is characterized by inflammatory changes in one of
the branches of the aorta, occurring almost
exclusively in individuals older than 50 years.
granulomatous enteritis I have no idea what the hell this is???
scleroderma autoimmune disease characterized by skin hardening,
can cause scaring and fibrosis in the lungs.
factors associated with poor 1. male gender
prognosis rheumatoid arthritis 2. early functional disability
3. high titer of rheumatoid factor or antibodies to
CCP
4. early development of radiologic erosions
5. extra-articular manifestations.
type of treatment for rheumatoid Disease-modifying anti-rheumatic drugs (DMARDs),
arthritis such as methotrexate (Rheumatrex®): Atimalarial
drugs, such as hydroxychloroquine (Plaquenil®).,
sulfasalazine (Azulfidine®) and
leflunomide (Arava®): "Biologic" therapies targeted at
inflammatory mediators, such as TNF-
(tumor necrosis factor alpha) that include
adalimumab (Humira®), infliximab (Remicade®),
golimumab (Simponi®), certolizuman pegol (Cimzia®),
and etanercept (Enbrel®).