Test bank for Tietz Fundamentals of Clinical Chemistry
b7 b7 b7 b7 b7 b7 b7
b7 and Molecular Diagnostics,
b7 b7 b7
8th Edition by Nader Rifai, PhD
b7 b7 b7 b7 b7 b7
Chapters 1 - 49 b7 b7 b7 b7
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
b7 b7 b7 b7 b7 b7 b7 b7
b7
b7 b7
Table of contents:
b7 b7
I. Principles Of Laboratory Medicine
b7 b7 b7 b7
Chapter 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
b7 b7 b7 b7 b7 b7 b7 b7
Chapter 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
Chapter 3. Clinical Evaluation of Methods
b7 b7 b7 b7 b7
Chapter 4. Evidence-Based Laboratory Medicine
b7 b7 b7 b7
Chapter 5. Establishment and Use of Reference Values
b7 b7 b7 b7 b7 b7 b7
Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
b7 b7 b7 b7 b7 b7 b7 b7
Chapter 7. Quality Management
b7 b7 b7
II. Analytical Techniques And Instrumentation
b7 b7 b7 b7
Chapter 8. Principles of Basic Techniques and Laboratory Safety
b7 b7 b7 b7 b7 b7 b7 b7
Chapter 9. Optical Techniques
b7 b7 b7
Chapter 10. Electrochemistry and Chemical Sensors
b7 b7 b7 b7 b7
Chapter 11. Electrophoresis
b7 b7
Chapter 12. Chromatography
b7 b7
Chapter 13. Mass Spectrometry
b7 b7 b7
Chapter 14. Enzyme and Rate Analyses
b7 b7 b7 b7 b7
Chapter 15. Immunochemical Techniques
b7 b7 b7
Chapter 16 Automation b7 b7
Chapter 17. Point-of-Care Instrumentation
b7 b7 b7
III. Analytes
b 7
Chapter 18. Amino Acids, Peptides, and Proteins
b7 b7 b7 b7 b7 b7
Chapter 19. Serum Enzymes
b7 b7 b7
Chapter 20. Tumor Markers and Cancer Genes
b7 b7 b7 b7 b7 b7
Chapter 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
Chapter 22. Carbohydrates
b7 b7
Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
b7 b7 b7 b7 b7 b7 b7 b7 b7
Chapter 24. Electrolytes and Blood Gases
b7 b7 b7 b7 b7
Chapter 25. Hormones b7 b7
Chapter 26. Catecholamines and Serotonin
b7 b 7 b7 b7
Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
b7 b 7 b7 b7 b7 b7
Chapter 28. Hemoglobin, Iron, and Bilirubin
b7 b7 b7 b7 b7
Chapter 29. Porphyrins and Porphyrias
b7 b7 b7 b7
Chapter 30. Therapeutic Drugs and Their Management
b7 b7 b7 b7 b7 b7
Chapter 31. Clinical Toxicology
b7 b7 b7
Chapter 32. Toxic Metals
b7 b 7 b7
IV. Pathophysiology
b 7
Chapter 33. Diabetes b7 b7
,Chapter 34. Cardiovascular Disease
b7 b 7 b7
Chapter 35. Kidney Disease
b7 b7 b7
Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
b7 b 7 b7 b7 b7 b7 b7 b7 b7 b7
Chapter 37. Liver Disease
b7 b7 b7 b7
Chapter 38. Gastrointestinal and Pancreatic Diseases
b7 b 7 b7 b7 b7
Chapter 39. Disorders of Bone and Mineral Metabolism
b7 b7 b7 b7 b7 b7 b7 b7
Chapter 40. Disorders of the Pituitary Gland
b7 b7 b7 b7 b7 b7 b7
Chapter 41. Disorders of the Adrenal Cortex
b7 b 7 b7 b7 b7 b7
Chapter 42. Thyroid Disorders
b7 b 7 b7
Chapter 43. Reproduction-Related Disorders
b7 b 7 b7
Chapter 44. Pregnancy and Prenatal Testing
b7 b7 b7 b7 b7 b7
Chapter 45. Newborn Screening and Inborn Errors of Metabolism
b7 b 7 b7 b7 b7 b7 b7 b7
Chapter 46. Pharmacogenetics
b7 b7
V. Molecular Diagnostics
b 7 b7
Chapter 47. Principles of Molecular Biology
b7 b7 b7 b7 b7
Chapter 48. Nucleic Acid Techniques and Applications
b7 b7 b7 b7 b7 b7
Chapter 49. Genomes and Nucleic Acid Alterations
b7 b7 b7 b7 b7 b7
, Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
b7 b7 b7 b7 b7 b7 b7 b7
TestBank
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7
MULTIPLE CHOICE b7
1. An individual working in a clinical chemistry laboratory is married to a sales
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
representative who works for a company that sells chemistry laboratory supplies.
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
When the laboratory manager requests a list of needed supplies, cost of supplies, and
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
vendors, this individual onlyrecommends the spouse’s company as the vendor. This is
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
considered to be a(n):
b7 b7 b7 b7
a. accounting issue. b7
b. possible conflict of interest. b7 b7 b7
c. maintenance of confidentiality issue. b7 b7 b7
d. problem with resource allocation. b7 b7 b7
ANS: B b7
Concern has been raised over the interrelationships between practitioners in the medical
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
fieldand commercial suppliers of drugs, devices, equipment, etc., to the medical
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
profession.
b7
Similarly, relationships have been scrutinized between clinical laboratorians and
b7 b7 b7 b7 b7 b7 b7 b7
manufacturers and providers of diagnostic equipment and supplies. These concerns led
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
the National Institutes of Health (NIH) in 1995 to require official institutional review of
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
financial disclosure by researchers and management of situations in which disclosure
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
indicates potentialconflicts of interest.
b7 b7 b7 b7 b7
DIF: 1 REF: b7 b7 b7 Page 4-5 b7 OBJ: 6 | 7 b7 b7 b7
2. A patient visits her physician stating that her prescribed painkiller is not working to
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
reduce the pain following her recent surgery. A friend of the patient claims that the
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
same painkiller―worked wonders‖ to reduce her pain after the same surgery. The
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
physician states that the difference in the effect of the drug might be caused by ,
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
which is studied in pharmacogenetics.
b7 b7 b7 b7 b7
a. epidemiology
b. an inherited disease b7 b7
c. a conflict of interest
b7 b7 b7
d. a genetic variation in drug-metabolizing enzymes
b7 b7 b7 b7 b7
ANS: D b7
Pharmacogenetics is the study of the genetic variation of drug metabolism b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
betweenindividuals.
b7 b7
DIF: 1 REF: b7 b7 b7 Page 3 b7 OBJ: 1 b7
3. John works in a molecular diagnostics laboratory and receives a blood sample that
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
has the name of a close friend printed on the bar-coded label. The genetic test that is
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
ordered on thefriend’s sample would provide diagnostic information about a disorder
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
that has a poor prognosis, and the test is usually performed by John. He asks a
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
fellow employee to analyzethe sample for him and not divulge the results. This
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
ethical issue concerns:
b7 b7 b7
a. confidentiality of patient genetic and medical information. b7 b7 b7 b7 b7 b7
b. a conflict of interest.
b7 b7 b7
c. resource allocation. b7
d. diagnostic accuracy. b7
b7 b7 b7 b7 b7 b7 b7
b7 and Molecular Diagnostics,
b7 b7 b7
8th Edition by Nader Rifai, PhD
b7 b7 b7 b7 b7 b7
Chapters 1 - 49 b7 b7 b7 b7
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
b7 b7 b7 b7 b7 b7 b7 b7
b7
b7 b7
Table of contents:
b7 b7
I. Principles Of Laboratory Medicine
b7 b7 b7 b7
Chapter 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
b7 b7 b7 b7 b7 b7 b7 b7
Chapter 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
Chapter 3. Clinical Evaluation of Methods
b7 b7 b7 b7 b7
Chapter 4. Evidence-Based Laboratory Medicine
b7 b7 b7 b7
Chapter 5. Establishment and Use of Reference Values
b7 b7 b7 b7 b7 b7 b7
Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
b7 b7 b7 b7 b7 b7 b7 b7
Chapter 7. Quality Management
b7 b7 b7
II. Analytical Techniques And Instrumentation
b7 b7 b7 b7
Chapter 8. Principles of Basic Techniques and Laboratory Safety
b7 b7 b7 b7 b7 b7 b7 b7
Chapter 9. Optical Techniques
b7 b7 b7
Chapter 10. Electrochemistry and Chemical Sensors
b7 b7 b7 b7 b7
Chapter 11. Electrophoresis
b7 b7
Chapter 12. Chromatography
b7 b7
Chapter 13. Mass Spectrometry
b7 b7 b7
Chapter 14. Enzyme and Rate Analyses
b7 b7 b7 b7 b7
Chapter 15. Immunochemical Techniques
b7 b7 b7
Chapter 16 Automation b7 b7
Chapter 17. Point-of-Care Instrumentation
b7 b7 b7
III. Analytes
b 7
Chapter 18. Amino Acids, Peptides, and Proteins
b7 b7 b7 b7 b7 b7
Chapter 19. Serum Enzymes
b7 b7 b7
Chapter 20. Tumor Markers and Cancer Genes
b7 b7 b7 b7 b7 b7
Chapter 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
Chapter 22. Carbohydrates
b7 b7
Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
b7 b7 b7 b7 b7 b7 b7 b7 b7
Chapter 24. Electrolytes and Blood Gases
b7 b7 b7 b7 b7
Chapter 25. Hormones b7 b7
Chapter 26. Catecholamines and Serotonin
b7 b 7 b7 b7
Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
b7 b 7 b7 b7 b7 b7
Chapter 28. Hemoglobin, Iron, and Bilirubin
b7 b7 b7 b7 b7
Chapter 29. Porphyrins and Porphyrias
b7 b7 b7 b7
Chapter 30. Therapeutic Drugs and Their Management
b7 b7 b7 b7 b7 b7
Chapter 31. Clinical Toxicology
b7 b7 b7
Chapter 32. Toxic Metals
b7 b 7 b7
IV. Pathophysiology
b 7
Chapter 33. Diabetes b7 b7
,Chapter 34. Cardiovascular Disease
b7 b 7 b7
Chapter 35. Kidney Disease
b7 b7 b7
Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
b7 b 7 b7 b7 b7 b7 b7 b7 b7 b7
Chapter 37. Liver Disease
b7 b7 b7 b7
Chapter 38. Gastrointestinal and Pancreatic Diseases
b7 b 7 b7 b7 b7
Chapter 39. Disorders of Bone and Mineral Metabolism
b7 b7 b7 b7 b7 b7 b7 b7
Chapter 40. Disorders of the Pituitary Gland
b7 b7 b7 b7 b7 b7 b7
Chapter 41. Disorders of the Adrenal Cortex
b7 b 7 b7 b7 b7 b7
Chapter 42. Thyroid Disorders
b7 b 7 b7
Chapter 43. Reproduction-Related Disorders
b7 b 7 b7
Chapter 44. Pregnancy and Prenatal Testing
b7 b7 b7 b7 b7 b7
Chapter 45. Newborn Screening and Inborn Errors of Metabolism
b7 b 7 b7 b7 b7 b7 b7 b7
Chapter 46. Pharmacogenetics
b7 b7
V. Molecular Diagnostics
b 7 b7
Chapter 47. Principles of Molecular Biology
b7 b7 b7 b7 b7
Chapter 48. Nucleic Acid Techniques and Applications
b7 b7 b7 b7 b7 b7
Chapter 49. Genomes and Nucleic Acid Alterations
b7 b7 b7 b7 b7 b7
, Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
b7 b7 b7 b7 b7 b7 b7 b7
TestBank
b7 b
7
MULTIPLE CHOICE b7
1. An individual working in a clinical chemistry laboratory is married to a sales
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
representative who works for a company that sells chemistry laboratory supplies.
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
When the laboratory manager requests a list of needed supplies, cost of supplies, and
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
vendors, this individual onlyrecommends the spouse’s company as the vendor. This is
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
considered to be a(n):
b7 b7 b7 b7
a. accounting issue. b7
b. possible conflict of interest. b7 b7 b7
c. maintenance of confidentiality issue. b7 b7 b7
d. problem with resource allocation. b7 b7 b7
ANS: B b7
Concern has been raised over the interrelationships between practitioners in the medical
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
fieldand commercial suppliers of drugs, devices, equipment, etc., to the medical
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
profession.
b7
Similarly, relationships have been scrutinized between clinical laboratorians and
b7 b7 b7 b7 b7 b7 b7 b7
manufacturers and providers of diagnostic equipment and supplies. These concerns led
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
the National Institutes of Health (NIH) in 1995 to require official institutional review of
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
financial disclosure by researchers and management of situations in which disclosure
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
indicates potentialconflicts of interest.
b7 b7 b7 b7 b7
DIF: 1 REF: b7 b7 b7 Page 4-5 b7 OBJ: 6 | 7 b7 b7 b7
2. A patient visits her physician stating that her prescribed painkiller is not working to
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
reduce the pain following her recent surgery. A friend of the patient claims that the
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
same painkiller―worked wonders‖ to reduce her pain after the same surgery. The
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
physician states that the difference in the effect of the drug might be caused by ,
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
which is studied in pharmacogenetics.
b7 b7 b7 b7 b7
a. epidemiology
b. an inherited disease b7 b7
c. a conflict of interest
b7 b7 b7
d. a genetic variation in drug-metabolizing enzymes
b7 b7 b7 b7 b7
ANS: D b7
Pharmacogenetics is the study of the genetic variation of drug metabolism b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
betweenindividuals.
b7 b7
DIF: 1 REF: b7 b7 b7 Page 3 b7 OBJ: 1 b7
3. John works in a molecular diagnostics laboratory and receives a blood sample that
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
has the name of a close friend printed on the bar-coded label. The genetic test that is
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
ordered on thefriend’s sample would provide diagnostic information about a disorder
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
that has a poor prognosis, and the test is usually performed by John. He asks a
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
fellow employee to analyzethe sample for him and not divulge the results. This
b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7 b7
ethical issue concerns:
b7 b7 b7
a. confidentiality of patient genetic and medical information. b7 b7 b7 b7 b7 b7
b. a conflict of interest.
b7 b7 b7
c. resource allocation. b7
d. diagnostic accuracy. b7
