NAPLEX PHARMACY FOUNDATIONS
PART 1 EXAM QUESTIONS AND
ANSWERS (VERIFIED AND UPDATED)
Somatic nervous system NTs - ANS ACh binds nicotinic receptors, usually in skeletal muscles
PNS NTs - ANS ACh binds muscarinic receptors
(usually GI, bladder, eyes)
SNS NTs - ANS NE, EPI binds adrenergic receptors
(b2 receptors in GI increases glucose production)
presynsaptic a2 agonists in CNS elicit what response - ANS decreases in overall sympathetic
output
name ACh -> muscrinic agonists and antagoists - ANS agonists: pilocarpine, bethanechol -->
increase SLUDD
antagonists: atropine, oxybutynin --> decreases SLUDD
name ACh -> nicotinic agonists and antagonists - ANS agonists: nicotine -> increases HR, BP
@2026/2027 ALLRIGHTS RESERVED.
,antagonists -> rocuronium -> neuromusclar blockade
name mainly peripheral a1 agonists and antagoists - ANS agonists: phenylephrine, dopamine
-> smooth muscle vasoconstriction, high bp
antagonists: doxazosin, carvedilol, phentolamine -> smooth muscle vasodilation, low bp
name mainly central a2 agonists and antagonists - ANS agonists: clonidine, brimodine ->
decreases EPI/NE -> low bp, hr
antagonists: ergot alkaloids -> increase bp, hr
name b1 agonists and antaognists - ANS agonists: dobumatine, isoprteerenol, dopamine ->
increase isotropic, co, hr
antagonists: bb -> decrease co, hr
name b2 agonists and antagonists - ANS agonists: albuterol, terbutaline, isopreterenol ->
bronchodilation
antagonists: NSBB -> bronchoconstriction
name dopamine agonists and antagonists - ANS agonists: levodopa, pramipexole -> many,
incl renal, cardiac, CNS effects
antagonists: 1st gen antipsychs (halo, metoclopramide) -> many
name 5ht agonists and antagonists - ANS agonists: triptans -> many, incl plt, gi, psych effects
@2026/2027 ALLRIGHTS RESERVED.
, antagonists: ondan, 2nd gen antipsychs -> many
catecholamine metabolism - ANS 1) tryosine
2) DOPA
3) dopamine
4) NE
5) EPI
6) tryptophan
7) 5ht
acetylcholinesterase inhibotors and effects - ANS drugs: donepezil, rivastigmine, galantamine
effect: increases ACh -> tx alzheimers
COMT inhibitor and effects - ANS drugs: entacapone
effect: prevents peripheral breakdown of levodopa -> tx parkinsons
MOA inhibitor and effects - ANS drugs: phenelzine, tranylcypromaine, isocarboxazid,
selegiline, rasagiline, methyele blue, linezolid
effects: blocks mao -> increase catecholamines -> happy
PD - ANS drug on body
PK - ANS body on drug (ADME)
chelation drugs - ANS quinolones
@2026/2027 ALLRIGHTS RESERVED.
PART 1 EXAM QUESTIONS AND
ANSWERS (VERIFIED AND UPDATED)
Somatic nervous system NTs - ANS ACh binds nicotinic receptors, usually in skeletal muscles
PNS NTs - ANS ACh binds muscarinic receptors
(usually GI, bladder, eyes)
SNS NTs - ANS NE, EPI binds adrenergic receptors
(b2 receptors in GI increases glucose production)
presynsaptic a2 agonists in CNS elicit what response - ANS decreases in overall sympathetic
output
name ACh -> muscrinic agonists and antagoists - ANS agonists: pilocarpine, bethanechol -->
increase SLUDD
antagonists: atropine, oxybutynin --> decreases SLUDD
name ACh -> nicotinic agonists and antagonists - ANS agonists: nicotine -> increases HR, BP
@2026/2027 ALLRIGHTS RESERVED.
,antagonists -> rocuronium -> neuromusclar blockade
name mainly peripheral a1 agonists and antagoists - ANS agonists: phenylephrine, dopamine
-> smooth muscle vasoconstriction, high bp
antagonists: doxazosin, carvedilol, phentolamine -> smooth muscle vasodilation, low bp
name mainly central a2 agonists and antagonists - ANS agonists: clonidine, brimodine ->
decreases EPI/NE -> low bp, hr
antagonists: ergot alkaloids -> increase bp, hr
name b1 agonists and antaognists - ANS agonists: dobumatine, isoprteerenol, dopamine ->
increase isotropic, co, hr
antagonists: bb -> decrease co, hr
name b2 agonists and antagonists - ANS agonists: albuterol, terbutaline, isopreterenol ->
bronchodilation
antagonists: NSBB -> bronchoconstriction
name dopamine agonists and antagonists - ANS agonists: levodopa, pramipexole -> many,
incl renal, cardiac, CNS effects
antagonists: 1st gen antipsychs (halo, metoclopramide) -> many
name 5ht agonists and antagonists - ANS agonists: triptans -> many, incl plt, gi, psych effects
@2026/2027 ALLRIGHTS RESERVED.
, antagonists: ondan, 2nd gen antipsychs -> many
catecholamine metabolism - ANS 1) tryosine
2) DOPA
3) dopamine
4) NE
5) EPI
6) tryptophan
7) 5ht
acetylcholinesterase inhibotors and effects - ANS drugs: donepezil, rivastigmine, galantamine
effect: increases ACh -> tx alzheimers
COMT inhibitor and effects - ANS drugs: entacapone
effect: prevents peripheral breakdown of levodopa -> tx parkinsons
MOA inhibitor and effects - ANS drugs: phenelzine, tranylcypromaine, isocarboxazid,
selegiline, rasagiline, methyele blue, linezolid
effects: blocks mao -> increase catecholamines -> happy
PD - ANS drug on body
PK - ANS body on drug (ADME)
chelation drugs - ANS quinolones
@2026/2027 ALLRIGHTS RESERVED.
