BIOM 3090 Pharmacodynamics Exam
Questions With Verified Answers
How does one obtain drugs classified as NAPRA I? - ANSWER Need prescription
for by sale by Pharmacist
How does one obtain drugs classified as NAPRA II? - ANSWER From Pharmacist,
without the need for prescription
How does one obtain drugs classified as NAPRA III? - ANSWER From a
pharmacy without the need of a pharmacist
What is the definition of a drug or ligand? - ANSWER Substance that brings
about change in biological function through chemical actions
What is the definition of pharmacodynamics? - ANSWER Actions of drugs on the
body
What is the definition of pharmacokinetics? - ANSWER Actions of the body on
drugs
True of False: all drugs must bind a receptor to exert their effect - ANSWER
False: eg. antacids are dissolved in gastric juices
What is the main type of bond that maintains the secondary structure of
proteins? - ANSWER Hydrogen bonds
Which bonds maintain the tertiary structure of proteins? - ANSWER 1. Hydrogen
2. Covalent (disulfide)
3. Ionic
What are the 2 major functions of physiological receptors? - ANSWER 1. Ligand
binding via ligand-binding domain
2. Message propagation via effector domain
What type of channel is the nicotinic acetylcholine receptor? What causes the
channel to open? What is the major electrolyte passed through it? - ANSWER
Ligand gated channel
- binding of 2 molecules of Ach to the alpha subunits
- Na+
Which channel does SUR1 regulate in pancreatic beta cells? - ANSWER ATP-
dependant K+ channel
, What is the most abundant class of receptors in the body? What are over half of
them dedicated to? - ANSWER GPCRs
- over half are dedicated to sensory perception
At what type of receptors do over half of all non-antibiotic drugs act at? -
ANSWER GPCRs
Which ion channels are activated by G stimulatory? G inhibitory? - ANSWER
Ca2+ channels by stimulatory
K+ channels by inhibitory
What is the action of Go? - ANSWER Inhibits Ca2+ channels
What is the action of Gq? - ANSWER Activates phospholipase C
What is the action of G12/13 - ANSWER Diverse ion transporter interactions
What are 2 examples of catecholamines? These ligands stimulate the production
of what? - ANSWER Stimulate production of 2nd messenger cAMP and cellular
effects based on tissue localization
What are 4 key G protein mediated messengers? - ANSWER 1. cAMP
2. cGMP
3. IP3
4. DAG
Where are beta 1 receptors found? (3)
What is their action at each of these areas? - ANSWER 1. SA node - increases HR
2. Cardiac muscle - increases contractility
3. Adipose tissue - increases lipolysis
Where are beta 2 receptors found? (6)
What is their action at each of these areas? - ANSWER 1. Bronchial smooth
muscle - dilates bronchioles
2. GI smooth muscle - constricts sphincters, relaxes gut wall
3. Uterus - relaxes uterine wall
4. Bladder - relaxes bladder
5. Liver - increases gluconeogenesis and glycolysis
6. Pancreas - increases insulin release
Where are beta 3 receptors found? (1)
What is their action at this area? - ANSWER Adipose tissue - increases lipolysis
What are 3 endogenous ligands that bind RTKs? - ANSWER Insulin, PDGF, VEGF
Questions With Verified Answers
How does one obtain drugs classified as NAPRA I? - ANSWER Need prescription
for by sale by Pharmacist
How does one obtain drugs classified as NAPRA II? - ANSWER From Pharmacist,
without the need for prescription
How does one obtain drugs classified as NAPRA III? - ANSWER From a
pharmacy without the need of a pharmacist
What is the definition of a drug or ligand? - ANSWER Substance that brings
about change in biological function through chemical actions
What is the definition of pharmacodynamics? - ANSWER Actions of drugs on the
body
What is the definition of pharmacokinetics? - ANSWER Actions of the body on
drugs
True of False: all drugs must bind a receptor to exert their effect - ANSWER
False: eg. antacids are dissolved in gastric juices
What is the main type of bond that maintains the secondary structure of
proteins? - ANSWER Hydrogen bonds
Which bonds maintain the tertiary structure of proteins? - ANSWER 1. Hydrogen
2. Covalent (disulfide)
3. Ionic
What are the 2 major functions of physiological receptors? - ANSWER 1. Ligand
binding via ligand-binding domain
2. Message propagation via effector domain
What type of channel is the nicotinic acetylcholine receptor? What causes the
channel to open? What is the major electrolyte passed through it? - ANSWER
Ligand gated channel
- binding of 2 molecules of Ach to the alpha subunits
- Na+
Which channel does SUR1 regulate in pancreatic beta cells? - ANSWER ATP-
dependant K+ channel
, What is the most abundant class of receptors in the body? What are over half of
them dedicated to? - ANSWER GPCRs
- over half are dedicated to sensory perception
At what type of receptors do over half of all non-antibiotic drugs act at? -
ANSWER GPCRs
Which ion channels are activated by G stimulatory? G inhibitory? - ANSWER
Ca2+ channels by stimulatory
K+ channels by inhibitory
What is the action of Go? - ANSWER Inhibits Ca2+ channels
What is the action of Gq? - ANSWER Activates phospholipase C
What is the action of G12/13 - ANSWER Diverse ion transporter interactions
What are 2 examples of catecholamines? These ligands stimulate the production
of what? - ANSWER Stimulate production of 2nd messenger cAMP and cellular
effects based on tissue localization
What are 4 key G protein mediated messengers? - ANSWER 1. cAMP
2. cGMP
3. IP3
4. DAG
Where are beta 1 receptors found? (3)
What is their action at each of these areas? - ANSWER 1. SA node - increases HR
2. Cardiac muscle - increases contractility
3. Adipose tissue - increases lipolysis
Where are beta 2 receptors found? (6)
What is their action at each of these areas? - ANSWER 1. Bronchial smooth
muscle - dilates bronchioles
2. GI smooth muscle - constricts sphincters, relaxes gut wall
3. Uterus - relaxes uterine wall
4. Bladder - relaxes bladder
5. Liver - increases gluconeogenesis and glycolysis
6. Pancreas - increases insulin release
Where are beta 3 receptors found? (1)
What is their action at this area? - ANSWER Adipose tissue - increases lipolysis
What are 3 endogenous ligands that bind RTKs? - ANSWER Insulin, PDGF, VEGF
