WEEK 1 COMPREHENSIVE STUDY GUIDE 2026
PRACTICE QUESTIONS AND ACCURATE
ANSWERS GRADED A+
◉ Defects in CYP3A5 that cause slow acetylation. Answer:
Polymorphic differences of 0% to 100%
Caucasian 5%
Japanese 29%
Chinese 27%
Koreans 30%
African-Americans 73%
◉ Factors of rational drug selection. Answer: Define the patient's
problem
Specify therapeutic objective
Collaborate with patient
Choose the treatment
Educate patient
Monitor effectiveness
,◉ Process of rational drug selection. Answer: Assess patient
Develop working and differential diagnosis
Diagnostic tests to confirm
Use evidence-based guidelines
Individualize for each patient
◉ Rational drug selection. Answer: Novice providers use analytic,
step-by-step decision making
◉ Rational drug selection. Answer: Experienced providers use
experience and pattern recognition. Use more systematic approach
with complex patients.
◉ Schedule I drug. Answer: Substances in this schedule have no
currently accepted medical use in the United States, a lack of
accepted safety for use under medical supervision, and a high
potential for abuse.
◉ Schedule II drug. Answer: Substances in this schedule have a high
potential for abuse which may lead to severe psychological or
physical dependence.
, ◉ Schedule I drug. Answer: heroin, lysergic acid diethylamide (LSD),
marijuana (cannabis), peyote, methaqualone, and 3,4-
methylenedioxymethamphetamine ("Ecstasy"). Use in labs only
◉ Schedule II drug. Answer: Narcotics-hydromorphone (Dilaudid),
methadone (Dolophine), meperidine (Demerol), oxycodone
(OxyContin, Percocet), and fentanyl (Sublimaze, Duragesic). Other
Schedule II narcotics include: morphine, opium, and codeine.
◉ Schedule II drug. Answer: Stimulants-amphetamine (Dexedrine,
Adderall), methamphetamine (Desoxyn), and methylphenidate
(Ritalin) and cocaine.
Other substances include amobarbital, glutethimide, and
pentobarbital, and secobarbital.
◉ Schedule III drugs. Answer: Have a potential for abuse less than
substances in Schedules I or II and abuse may lead to moderate or
low physical dependence or high psychological dependence.
◉ Schedule III drugs. Answer: Narcotics- combination products
containing less than 15 milligrams of hydrocodone per dosage unit
(Vicodin), products containing not more than 90 milligrams of
codeine per dosage unit (Tylenol with Codeine), and buprenorphine
(Suboxone).