COMSAE Drugs Exam Questions with
Complete Solutions5
Warfarin- Mechanism - ANSWERS-Interferes w/ vitamin K dependent clotting factors (II, VII, IX,
X, C, S)
Warfarin- Pathway, effect on PT/INR - ANSWERS-Extrinsic factor, increased PT
Warfarin- Clinical Use - ANSWERS-Chronic anticoagulation
Warfarin- Pregnancy - ANSWERS-CI in pregnant women--crosses placenta
Warfarin- AE - ANSWERS-Bleeding, tissue necrosis
Digoxin- MOA - ANSWERS-Direct inhibition of Na/K ATPase --> indirect inhibition of Na/Ca
exchange
Increased Calcium concentration --> positive ionotropy.
Stimulates vagus nerve --> decrease HR
Digoxin- Clinical use - ANSWERS-Heart failure (increase contractility)
atrial fibrillation (decrease conduction at AV node and depression of SA node)
Digoxin- AE - ANSWERS-Hyperkalemia, blurry yellow vision, arrhythmias, AV block
Digoxin Toxicity- Treatment - ANSWERS-Slowly normalize K+, cardiac pacer, anti-digoxin Fab
fragments, Mg+
, Beta Blockers- Mechanism - ANSWERS-Decrease SA and AV nodal activity by decreasing
cAMP/Ca2+
Decrease slope of phase 4
Beta Blockers- Use - ANSWERS-SVT, ventricular rate control for a-fib and a-flutter
Beta Blockers- AE - ANSWERS-Exacerbation of COPD/asthma
CV effects: bradycardia, AV block, HF
Metronidazole- MOA - ANSWERS-Forms toxic free radical metabolites in bacteria.
Bacteriocidal
Metronidazole- Clinical Use - ANSWERS-GET GAP
Giardia, Entamoeba, Trichomonas, Gardnerella vaginalis, Anaerobes (C. diff), H. Pylori (penicillin
injury)
(Anaerobic infection below the diaphragm)
Metronidazole- AE - ANSWERS-Disulfiram-like reaction (flushing, tachycardia, hypotension) with
alcohol.
Headache, metallic taste
Typical antipsychotics (-azine)- MOA - ANSWERS-Block dopamine D2 receptor --> increase cAMP
Typical antipsychotics - Clinical Use - ANSWERS-Schizophrenia, pyschosis, bipolar, Huntington,
OCD
Complete Solutions5
Warfarin- Mechanism - ANSWERS-Interferes w/ vitamin K dependent clotting factors (II, VII, IX,
X, C, S)
Warfarin- Pathway, effect on PT/INR - ANSWERS-Extrinsic factor, increased PT
Warfarin- Clinical Use - ANSWERS-Chronic anticoagulation
Warfarin- Pregnancy - ANSWERS-CI in pregnant women--crosses placenta
Warfarin- AE - ANSWERS-Bleeding, tissue necrosis
Digoxin- MOA - ANSWERS-Direct inhibition of Na/K ATPase --> indirect inhibition of Na/Ca
exchange
Increased Calcium concentration --> positive ionotropy.
Stimulates vagus nerve --> decrease HR
Digoxin- Clinical use - ANSWERS-Heart failure (increase contractility)
atrial fibrillation (decrease conduction at AV node and depression of SA node)
Digoxin- AE - ANSWERS-Hyperkalemia, blurry yellow vision, arrhythmias, AV block
Digoxin Toxicity- Treatment - ANSWERS-Slowly normalize K+, cardiac pacer, anti-digoxin Fab
fragments, Mg+
, Beta Blockers- Mechanism - ANSWERS-Decrease SA and AV nodal activity by decreasing
cAMP/Ca2+
Decrease slope of phase 4
Beta Blockers- Use - ANSWERS-SVT, ventricular rate control for a-fib and a-flutter
Beta Blockers- AE - ANSWERS-Exacerbation of COPD/asthma
CV effects: bradycardia, AV block, HF
Metronidazole- MOA - ANSWERS-Forms toxic free radical metabolites in bacteria.
Bacteriocidal
Metronidazole- Clinical Use - ANSWERS-GET GAP
Giardia, Entamoeba, Trichomonas, Gardnerella vaginalis, Anaerobes (C. diff), H. Pylori (penicillin
injury)
(Anaerobic infection below the diaphragm)
Metronidazole- AE - ANSWERS-Disulfiram-like reaction (flushing, tachycardia, hypotension) with
alcohol.
Headache, metallic taste
Typical antipsychotics (-azine)- MOA - ANSWERS-Block dopamine D2 receptor --> increase cAMP
Typical antipsychotics - Clinical Use - ANSWERS-Schizophrenia, pyschosis, bipolar, Huntington,
OCD
