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... - ✔✔✔-•Disrupts microorganisms protein structure •Ionizing radiation can be lethal to
humans •Gamma rays used on instruments and supplies. •Irradiated diets are nutritionally
supplemented. •Non-ionizing radiation less penetrability. •Irradiated items are not radioactive.
... - ✔✔✔-•Table 9.2 - active contact zoonoses
... - ✔✔✔-> risk of infection if organisms are resistant +/or highly virulent; > risk if the animals
are particularly susceptible (e.g. immunocompromised).
... - ✔✔✔-Antigen-specific antibodies can be identified in diagnostic tests.
... - ✔✔✔-Controlled exposure to antigens is the principle behind vaccination against bacterial,
viral and allergic diseases.
... - ✔✔✔-Diagnostic procedures are performed at scheduled intervals.
... - ✔✔✔-Enteritis can be caused by bacteria, viruses, endoparasites, spoiled food, or
contaminated water; Salmonella, canine parvovirus, feline panleukopenia, MHV, roundworms,
tapeworms, hookworms, and coccidian; Spoiled food and contaminated water from the direct
action of bacteria, mold, fungi or their chemical toxins.
... - ✔✔✔-Hamsters, for example, show no signs of the viral disease lymphocytic
choriomeningitis (LCM) when they carry the disease. People who handle hamsters infected with
this virus can become ill with the disease. Mice exposed to such hamsters frequently develop
serious clinical disease
... - ✔✔✔-Imported primates and other wild animals, often contain exotic disease organisms.
•Be on alert for outbreaks and zoonotic health problems. •Cleanliness and sanitation are still
backbone of disease prevention and control.
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... - ✔✔✔-Indirectly = airborne or aerosol transmission
... - ✔✔✔-Microscopic lesions can be seen under the microscope.
... - ✔✔✔-Mortality refers to the number of animals that die from a disease.
... - ✔✔✔-Sick animals that seem near death are said to be moribund.
... - ✔✔✔-Vertical transmission = 1 generation to next = mother to offspring
"Modified SPF" - ✔✔✔-a barrier with less stringent procedures; animals purchased only from
SPF vendors
Abduction - ✔✔✔-Movement of bone away from midline
Abscesses - ✔✔✔-Swellings filled with purulent material (pus) are a mixture of dead bacteria,
liquefied tissue, and white blood cells. Most common just under skin, at site of puncture
wounds. Bacteria are deposited under skin and the skin closes over them. White blood cells to
fight the infection. White blood cells release substances that digest and liquefy some of the
tissue, the bacteria, and themselves.
Activity Cages - ✔✔✔-rodent - an attached wheel-shaped section; nonhuman primates - bars,
ropes, swings, and sometimes toys; dogs and other larger animals - runs
Acute - ✔✔✔-rapid onset and brief duration
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Adduction - ✔✔✔-Movement toward the midline
After antigen exposure, immune system produces ______ and _______ against specific foreign
substance that initially _______ their production. - ✔✔✔-After antigen exposure, immune
system produces lymphocytes and antibodies against specific foreign substance that initially
stimulated their production. Acquired (developed), active immunity to that substance
Alleles - ✔✔✔-different forms of the same gene at a given locus; Within a species, there may be
dozens of alleles for a given gene. Thus, an animal often has 2 different forms (alleles) of the
same gene, 1 inherited from each parent
Allergy or Hypersensitivity - ✔✔✔-Instead of helping, allergic immune response causes
additional tissue damage. One reaction is called anaphylactic shock. •Some organisms are
adapted to surviving in an animal host despite the immune response. Parasites, such as
intestinal roundworms, are a classic example. •Newborns have temporary level of passive
immunity. Antibodies acquired through mothers' milk or across the placenta. Passively
transferred antibodies protect for the first few weeks of life until old enough to produce own
antibodies. •Only infection or vaccination can stimulate a long-lasting active immune response.
Alopecia - ✔✔✔-Loss of hair; Reasons - excessive grooming, metabolic dysfunction, external
parasites, and nutritional disorders; External parasites, such as fleas, mites, or lice and
nutritional deficiencies of some vitamins and minerals common cause => skin surface is not
normal. Overall thinning from hair shed in spring and fall.
Anatomically - ✔✔✔-body system where symptoms occur
Anestrus is... - ✔✔✔-the long period of time between breeding seasons
Animal Acquisition - ✔✔✔-Centralized = better price, transport, housing and health. •Animals
requests consider: source, strain, sex, age, weight, pathogen status, number and transportation.
•Do not change suppliers until study is completed. •Vendor animal health survey - sample
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subjected to diagnostic procedures to determine health status. •Use correct terminology to
describe pathogen status. •SPF or VAF may mean different things. •Larger animals screening -
worming and vaccination schedules, health history, and USDA paperwork.
Animal Facility Designs - ✔✔✔-Non-husbandry-related functions: About 25 percent of the total
floor space; Legal requirements must be taken into account (waste disposal, noise, odor control,
and facility security); Design determined by the nature of the research (safety of its employees,
the animals, and the surrounding community); Space requirements and traffic flow; Protection
of the animals from common diseases
Animal Health Maintenance requires looking for... - ✔✔✔-Note subtle changes in animal
behavior, physical appearance, or daily activity. •Early discovery of an abnormality in an animal
may reduce animal suffering and colony disease problems and prevent the compromise of an
experiment. •Contagious viral infection a threat in colony animals.
Appendicular Skeleton is made up of... - ✔✔✔-bones and includes the pectoral girdle
Artificial Insemination and In Vitro Fertilization - ✔✔✔-Collection of sperm or eggs/embryos;
necessary for production of some genetically engineered mice; Important for rederivation to
eliminate certain diseases from a colony; Technique requires precise timing based on knowledge
of reproductive cycles
Autoclaves pic - ✔✔✔-Add pic
Axenic - Microbial Status - ✔✔✔-completely free of all detectable microorganisms and parasites
Axial Skeleton - ✔✔✔-Skull -Two parts: cranium and facial; Vertebrae -Vertebral column
consists of bones known as vertebrate; Ribs and sternum; Part of the thoracic region
Bacterium = bacteremia - ✔✔✔-...