PAPER 2026 FULL SOLUTION STUDY GUIDE
◉ Pharmaceutic. Answer: drug dissolves
◉ Pharmacokinetic. Answer: what the body does to the drug
(ADME)
◉ Pharmacodynamic. Answer: what the drug does to the body
◉ ADME A. Answer: absorption
◉ ADME D. Answer: distribution
◉ ADME M. Answer: metabolism (liver)
◉ ADME E. Answer: excretion (kidney)
◉ First-pass effect. Answer: oral drugs are metabolized by the liver
before circulation (bioavailability)
, ◉ Protein binding. Answer: albumin binds drugs → only the free
drug is active
◉ Half-life. Answer: time for the drug level to decrease by 50%
◉ CYP450 Substrate. Answer: drug being metabolized (liver)
◉ CYP450 Inducer. Answer: speeds up metabolism → ↓ drug levels
◉ CYP450 Inhibitor. Answer: slows metabolism → ↑ toxicity risk
◉ Agonist. Answer: activates the receptor
◉ Antagonist. Answer: blocks the receptor
◉ Side effect. Answer: predictable but unintended
◉ Adverse Drug Reaction (ADR). Answer: harmful or dangerous
response
◉ Hematopoiesis Myeloid line. Answer: RBCs, platelets, neutrophils,
eosinophils, basophils, monocytes