NSG 552 Psychopharmacology Exam 1: Modules 1-3
Major organ that breaks down drugs in the body=
> liver
Electrolyte imbalance commonly associated with psychotropic
medication:
> hyponatremia
The time needed to clear 50% of drugs from the plasma:
> half-life
The process of becoming desensitized and less responsive to a
particular medication dose overtime necessitating an increase:
> Drug tolerance/desensitization
A ration describing toxic dose to effective dose:
> Therapeutic index
A chemical that binds to a receptor to produce a biologic response:
> Agonist
,A chemical that binds to a receptor but does not fully activate the
receptor:
> partial agonist
A chemical that binds to a receptor, blocking it to inhibit a biologic
response:
> Antagonist
An agent that binds to the same receptor as an agonist but induces an
opposite biological response:
> inverse agonist
A usually undesired but foreseeable effect that occurs regardless of
dose and often resolves after continued therapy:
> side effect
S/S opposite of what it was meant to treat:
> paradoxical reaction
CYP450 interactions are part of:
> Metabolism
,Escitalopram is a CYP450-3A4 substrate. If the PMHNP adds a second
medication that is a 3A4 inducer, what happens to the escitalopram
levels?
> They decrease
Binding
> A protein, macromolecule, nucleic acid, or small molecule to which a
given drug binds, resulting in an alteration of the normal function of the
bound molecule and a desirable therapeutic effect.
Affinity
> the extent or fraction to which a drug binds to receptors at any given
drug concentration
CYP450
> Cytochrome P450 (CYP450), a large superfamily of heme-thiolate
proteins, are involved in the metabolism of both exogenous and
endogenous compounds
Symptoms of schizophrenia are divided into these two categories:
> Positive and negative
, T/F Antipsychotic polypharmacy can increase the risk of re-
hospitalization, diabetes, EPS, sedation, seizures, metabolic effects,
mortality, and sudden cardiac death.
>T
Alogia, anhedonia, avolition and cognitive symptoms:
> Negative symptoms
Delusions, hallucinations, hostility, grandiosity:
> Positive Symptoms
Another name for 1st generation antipsychotics:
> Typical antipsychotics, FGA
Another name for 2nd generation antipsychotics:
> Atypical antipsychotics, SGA
First line treatment for Schizophrenia:
> Second-generation antipsychotics (except clozapine)
This class is associated with fewer neurological side effects and effective
for both positive and negative symptoms:
Major organ that breaks down drugs in the body=
> liver
Electrolyte imbalance commonly associated with psychotropic
medication:
> hyponatremia
The time needed to clear 50% of drugs from the plasma:
> half-life
The process of becoming desensitized and less responsive to a
particular medication dose overtime necessitating an increase:
> Drug tolerance/desensitization
A ration describing toxic dose to effective dose:
> Therapeutic index
A chemical that binds to a receptor to produce a biologic response:
> Agonist
,A chemical that binds to a receptor but does not fully activate the
receptor:
> partial agonist
A chemical that binds to a receptor, blocking it to inhibit a biologic
response:
> Antagonist
An agent that binds to the same receptor as an agonist but induces an
opposite biological response:
> inverse agonist
A usually undesired but foreseeable effect that occurs regardless of
dose and often resolves after continued therapy:
> side effect
S/S opposite of what it was meant to treat:
> paradoxical reaction
CYP450 interactions are part of:
> Metabolism
,Escitalopram is a CYP450-3A4 substrate. If the PMHNP adds a second
medication that is a 3A4 inducer, what happens to the escitalopram
levels?
> They decrease
Binding
> A protein, macromolecule, nucleic acid, or small molecule to which a
given drug binds, resulting in an alteration of the normal function of the
bound molecule and a desirable therapeutic effect.
Affinity
> the extent or fraction to which a drug binds to receptors at any given
drug concentration
CYP450
> Cytochrome P450 (CYP450), a large superfamily of heme-thiolate
proteins, are involved in the metabolism of both exogenous and
endogenous compounds
Symptoms of schizophrenia are divided into these two categories:
> Positive and negative
, T/F Antipsychotic polypharmacy can increase the risk of re-
hospitalization, diabetes, EPS, sedation, seizures, metabolic effects,
mortality, and sudden cardiac death.
>T
Alogia, anhedonia, avolition and cognitive symptoms:
> Negative symptoms
Delusions, hallucinations, hostility, grandiosity:
> Positive Symptoms
Another name for 1st generation antipsychotics:
> Typical antipsychotics, FGA
Another name for 2nd generation antipsychotics:
> Atypical antipsychotics, SGA
First line treatment for Schizophrenia:
> Second-generation antipsychotics (except clozapine)
This class is associated with fewer neurological side effects and effective
for both positive and negative symptoms:
