Test Bank Complete_ Lehne's Pharmacotherapeutics for Advanced Practice Nurses and Physician Assistants ACTUAL (3rd Edition, 2026) By Rosenthal All Chapters 1–94

Test Bank Complete_ Lehne's Pharmacotherapeutics for
Advanced Practice Nurses and Physician Assistants ACTUAL
(3rd Edition, 2026) By Rosenthal All Chapters 1–94




1. A drug with a long half-life will:

A. Act faster
B. Stay in the body longer
C. Be less potent
D. Require IV administration
Answer: B
Rationale: Half-life determines duration of drug in the body.



2. First-pass metabolism occurs in the:

A. Kidney
B. Liver
C. Lung
D. Intestine only
Answer: B

,3. Bioavailability refers to:

A. Drug toxicity
B. Amount of drug reaching systemic circulation
C. Drug excretion rate
D. Drug absorption in kidneys
Answer: B




4. A drug with high protein binding:

A. Is more active
B. Has longer duration
C. Is quickly excreted
D. Has no effect
Answer: B



5. Agonists:

A. Block receptors
B. Activate receptors
C. Destroy enzymes
D. Reduce absorption
Answer: B




🟠 CARDIOVASCULAR PHARMACOLOGY


6. ACE inhibitors primarily:

2 of 23

, A. Increase heart rate
B. Decrease angiotensin II
C. Increase potassium loss
D. Increase sodium retention
Answer: B



7. Major adverse effect of ACE inhibitors:

A. Hypokalemia
B. Hyperkalemia
C. Hypernatremia
D. Hypoglycemia
Answer: B



8. Beta blockers should be used cautiously in:

A. Asthma
B. Hypertension
C. Diabetes
D. Hyperlipidemia
Answer: A



9. Warfarin mechanism:

A. Blocks platelets
B. Inhibits vitamin K clotting factors
C. Dissolves clots
D. Activates thrombin
Answer: B



10. Antidote for warfarin:

A. Vitamin C
B. Vitamin K
C. Heparin
D. Protamine
Answer: B



11. Heparin antidote:

A. Protamine sulfate
B. Vitamin K
C. Naloxone