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Terms in this set (127)
Pharmacodynamics The process by which a medication works on the
body.
Pharmacokinetics The process by which drugs are absorbed,
distributed within the body, metabolized, and
excreted.
Pharmacogenomics The study of the influence of genetic factors on drug
response that result in the absence, overabundance,
or insufficiency of drug-metabolizing enzymes
Medication side effect a nearly unavoidable secondary effect of a drug
produced at therapeutic doses which is generally
predictable and with an intensity that is dose-
dependent
Adverse Effect A drug-induced, secondary effect of a drug that
produces a change in a patients condition that is
noxious, harmful or unpleasant, which requires
treatment or reduction or discontinuation of the drug
and which usually occurs at therapeutic doses.
Type A adverse drug reactions exaggerated, but otherwise expected
pharmacological effect of a drug -> predictable and
dose dependent -> ex. toxicity of overdose, side
effects, secondary effects, drug interactions
,Type B adverse drug reactions idiosyncratic effects (not expected) -> dose
independent and unpredictable -> intolerance,
hypersensitivity, pseudo allergic, idiosyncratic
Drug tolerance the tendency for larger doses of a drug to be
required over time to achieve the same effect
Physical drug dependence condition where a person's body becomes unable to
function normally without a particular drug
Psychological dependence a condition in which a person believes that a drug is
needed in order to feel good or to function normally
Allergic reaction An immunologic hypersensitivity reaction resulting
from the unusual sensitivity of a patient to a particular
medication; a type of adverse drug event.
Idiosyncratic or paradoxical reaction When a drug may cause a totally unexpected and
often opposite effect in a few patients
Carcinogenic reaction medications and environmental chemicals that are
thought to cause cancer
Teratogenic reaction Refers to the drug induced damage that develops in
the fetus
Beneficial potentiative drug-drug Aspirin and Codeine are both analgesic drugs and
interaction when administered concurrently the combo provides
better pain relief than either one alone. What type of
drug interaction is this?
Beneficial Potentiative Drug-Drug Use of Beta Blockers and Diuretics together for
Interaction hypertension will provide better control blood
pressure. What type of drug interaction is this?
, Harmful potentiative Drug-Drug Use of diazepam together with Morphine will have
interaction additive CNS depression and could lead to
respiratory distress. What type of drug interaction is
this?
Harmful potentiative Drug-Drug Concurrent use of aspirin with Coumadin will
interaction significantly increase each others inhibitory effects
on blood coagulation, resulting in an increase risk for
bleeding. What type of drug interaction is this?
Beneficial inhibitory drug interaction Use of Naloxone after an overdose of Meperidine is
an example of what type of drug interaction?
Beneficial inhibitory drug interaction Giving Protamine when there is excessive bleeding
from overdose of Heparin is an example of what type
of drug interaction?
Harmful inhibitory drug interaction Giving Naloxone to a patient who is physically
dependent to Morphine will reverse Morphines
effects provoking an acute withdrawal syndrome.
What type of drug interaction is this?
Harmful inhibitory drug interaction Administering loperamide and Milk of Magnesia
together will cancel each others actions producing
no benefit for the patient either way. What type of
drug interaction is this?
Harmful inhibitory drug interaction Injecting NPH insulin into a bottle of regular insulin
causing a precipitate and inactivation of the regular
insulin is an example of what type of drug
interaction?
Pharmacokinetic Drug interctions type of drug-drug interaction that occurs when the
pharmacokinetics of one drug alter the clinical
effects of another drug by altering its
pharmacokinetics