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lactic acid, pyruvic acids and CO2
alpha 1 nonselective beta receptor blockers
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block alpha receptors in the vasculature to cause vasodilation and beta
receptors in the heart and lungs to decrease heart rate and contractility
carvedilol and labetalol
,autoregulation is lost when
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the systemic MAP is <50 and >150
traumatic brain injury
ICH
ischemic strokes
when ICP is >35 for more than 20-30 mins
What is procalcitonin used for?
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used to detect sepsis and severe sepsis causd by a bacterial organism
clinical signs of impending brain herniation
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significant pupillary asymmetry
unilateral or bilateral fixed and dilated pupil
decorticate or decerberate posturing
respiratory depression
why is norepi preferred in sepsis
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, potent vasoconstrictor without adverse side effects of tachycardia and
other dysrythmias
symptoms of ICH
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altered LOC
N/V
sudden, severe headache
seizures
sudden weakness or paralysis
sudden vision changes
loss of balance or coordination
difficulty understanding, speaking
what happens when the first line of defense is penetrated
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immune mediated inflammatory reaction
- series of innate (inflammatory) and acquired (immune) responses
these two defenses are the second and third line of defense
- the body identifies harmful molecules and rapidly releases neutrophils to
the tissue injury (second line of defense)
then 48 hours later there is an influx of cells consisting of macrophages
and T cells (third line of defense)
impact of hypoxemia: GI
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absence of bowel sounds may be late indication of blood being shunted to
vital organs
can cause an ileus
strength of contraction is determined by
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LVEF; the vigor of contraction regardless of preload
what happens in ARDS
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diffuse, inflammatory lung injury leads to increased pulmonary vascular
permeability and as a result, fluid leaks from the capillaries into the alveoli
which interferes with gas exchange
cardiac output
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the effectiveness of the pump to circulate blood throughout the body