PATH 3610 DE MIDTERM 2 EXAM
QUESTIONS 100% CORRECT
ANSWERS
Which of the following statements is false?
A ) IgM is the immunoglobulin with the smallest molecular weight
B ) IgG represents the largest proportion of immunoglobulin in normal serum
C ) IgA is found in secretions (tears, mucus, etc.) and helps protect mucosal barriers -
Answer- A ) IgM is the immunoglobulin with the smallest molecular weight
In Type I hypersensitivity reactions, the effects seen primarily relate to initial:
A ) recruitment of inflammatory cells
B ) release of mediators from mast cells
C ) secretion of cytokines and chemokines - Answer- B ) release of mediators from mast
cells
A principal role of histocompatibility molecules is:
A ) To initiate auto immune diseases
B ) To cause tissue and organ rejection (in transplantation)
C ) To bind foreign proteins for presentation to appropriate antigen-specific T-cells -
Answer- C ) To bind foreign proteins for presentation to appropriate antigen-specific T-
cells
Which of the following has not been implicated in the development of auto-immune
disease?
A ) loss of tolerance
B ) a defect in the normal deletion of potentially self-reactive lymphocyte clones
C ) the development of energy with advanced age - Answer- C ) the development of
energy with advanced age
The deposition of immune complexes in blood vessel walls, seen in immune complex-
mediated (Type III) hypersensitivity causes:
A ) necrotizing vasculitis
, B ) widening of endothelial junctions
C ) blockage of blood vessels - Answer- A ) necrotizing vasculitis
Infection with HIV causes AIDS (acquired immune deficiency syndrome) because:
A ) neutrophil granulocyte precursors in the bone marrow are destroyed
B ) the virus causes uncontrolled replication of CD8+ cells
C ) the virus damages CD4+ T cells - Answer- C ) the virus damages CD4+ T cells
Delayed-type hypersensitivity is initiated by:
A ) CD8+ T cells
B ) CD4+ T cells
C ) macrophages - Answer- B ) CD4+ T cells
The secondary immune response is characterized by which of the following, as
compared to the primary immune response?
A ) a longer lag period
B ) a greater magnitude
C ) later IgG production - Answer- B ) a greater magnitude
Transcription of HIV proviral-DNA in CD4+ T cells leads to:
A ) productive infection and cell death
B ) prolonged latency of HIV infection
C ) production of cytokines - Answer- A ) productive infection and cell death
Amyloid consists of:
A ) insoluble, beta-pleated fibrillar protein
B ) immunoglobulin light chains
C ) amorphous material deposited in tissues - Answer- A ) insoluble, beta-pleated
fibrillar protein
Which of the following represents the end stage of wound repair?
A ) proliferation and mobilization of fibroblasts
B ) dominance of fibrocytes and abundant collagen
C ) proliferation of capillary buds and formation of abundant capillaries - Answer- B )
dominance of fibrocytes and abundant collagen
Which of the following is a cause of non-granulomatous chronic inflammation?
A ) foreign material such as talc or sponge fibres
B ) chronic viral infections
QUESTIONS 100% CORRECT
ANSWERS
Which of the following statements is false?
A ) IgM is the immunoglobulin with the smallest molecular weight
B ) IgG represents the largest proportion of immunoglobulin in normal serum
C ) IgA is found in secretions (tears, mucus, etc.) and helps protect mucosal barriers -
Answer- A ) IgM is the immunoglobulin with the smallest molecular weight
In Type I hypersensitivity reactions, the effects seen primarily relate to initial:
A ) recruitment of inflammatory cells
B ) release of mediators from mast cells
C ) secretion of cytokines and chemokines - Answer- B ) release of mediators from mast
cells
A principal role of histocompatibility molecules is:
A ) To initiate auto immune diseases
B ) To cause tissue and organ rejection (in transplantation)
C ) To bind foreign proteins for presentation to appropriate antigen-specific T-cells -
Answer- C ) To bind foreign proteins for presentation to appropriate antigen-specific T-
cells
Which of the following has not been implicated in the development of auto-immune
disease?
A ) loss of tolerance
B ) a defect in the normal deletion of potentially self-reactive lymphocyte clones
C ) the development of energy with advanced age - Answer- C ) the development of
energy with advanced age
The deposition of immune complexes in blood vessel walls, seen in immune complex-
mediated (Type III) hypersensitivity causes:
A ) necrotizing vasculitis
, B ) widening of endothelial junctions
C ) blockage of blood vessels - Answer- A ) necrotizing vasculitis
Infection with HIV causes AIDS (acquired immune deficiency syndrome) because:
A ) neutrophil granulocyte precursors in the bone marrow are destroyed
B ) the virus causes uncontrolled replication of CD8+ cells
C ) the virus damages CD4+ T cells - Answer- C ) the virus damages CD4+ T cells
Delayed-type hypersensitivity is initiated by:
A ) CD8+ T cells
B ) CD4+ T cells
C ) macrophages - Answer- B ) CD4+ T cells
The secondary immune response is characterized by which of the following, as
compared to the primary immune response?
A ) a longer lag period
B ) a greater magnitude
C ) later IgG production - Answer- B ) a greater magnitude
Transcription of HIV proviral-DNA in CD4+ T cells leads to:
A ) productive infection and cell death
B ) prolonged latency of HIV infection
C ) production of cytokines - Answer- A ) productive infection and cell death
Amyloid consists of:
A ) insoluble, beta-pleated fibrillar protein
B ) immunoglobulin light chains
C ) amorphous material deposited in tissues - Answer- A ) insoluble, beta-pleated
fibrillar protein
Which of the following represents the end stage of wound repair?
A ) proliferation and mobilization of fibroblasts
B ) dominance of fibrocytes and abundant collagen
C ) proliferation of capillary buds and formation of abundant capillaries - Answer- B )
dominance of fibrocytes and abundant collagen
Which of the following is a cause of non-granulomatous chronic inflammation?
A ) foreign material such as talc or sponge fibres
B ) chronic viral infections
