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What medication is used to treat heavy menses in women who do not want their
fertility affected? - ANSWER ✓ tranexamic acid (antifibrinolytic)
What is a normal menstrual cycle? - ANSWER ✓ 21-35 days lasting 2-7 days;
adolescents may have larger range of 21-45 days
What initial labs to check in AUB? - ANSWER ✓ Pregnancy test, cbc, pt, ptt, tsh,
fibrinogen level, iron studies
others: prolactin, testosterone, 17 hydroxyprogesterone, chlamydia
AUB tx in outpatient settings - ANSWER ✓ oral contraceptives, progestins,
NSAIDs, levonorgestrel IUD, antifibrinolytics
Tx if not bleeding AUB - ANSWER ✓ cyclic OCP (depo provera or noethindone)
Tx if bleeding - ANSWER ✓ consider monophasic OCP 30-50 ug ethinyl
estradiol/ 0.3 mg norgestrel
What to use in AUB if estrogen is contraindicated? - ANSWER ✓ norethindrone
acetate 5-10 mg or tranexamic acid 1.3 mg TID bleeding menses (5 days max)
Tx for intractable heavy bleeding - ANSWER ✓ GnRH agonist- depot leuprolide
3.75 mg IM q month for 6 mos
,Refer to hospital in severe AUB cases - ANSWER ✓ hgb less than 7 or
orthostasis
Tx of mild AUB - ANSWER ✓ duration of heavy bleeding less than 3 months/
hgb normal
observation
keep menstrual calendar
encourage use of antiprostaglandin meds to decrease menorrhagia
Tx of moderate AUB - ANSWER ✓ menses heavy/frequent q 1-3 weeks/mild
anemia
CKD diagnosis - ANSWER ✓ Either of the following must be present for 3+mo: §
eGFR: <60 § ACR: >30mg/g § Markers of kidney damage [1+: glomerular
hematuria, kidney biopsy abnm, polycystic kidney dx on imaging]
Persistent albuminuria categories - ANSWER ✓ A1=<30mg/g
A2= 30-300mcg/g
A3=>300mcg/g
CKD stage s/s - ANSWER ✓ Stage 1 (90-100% function): No symptoms. Other
health issues DM, HTN, obesity
Stage 2 (60-89% function: No symptoms. Protein leaking in urine <200mcg
Stage 3 (30-59% function): Edema, fatigue, back pain, foamy, darker urine,
microalbumin (>200mcg), food restrictions: sodium / phosphorus
Stage 4 (15-29% function): Stage 3 symptoms + n/v, difficulty concentrating,
tingling in toes / fingers, loss of appetite, sleep issues, kidney dialysis, renal
dietitian required, more food restrictions: less K+
Stage 5 (0-14% function): Stage 4 symptoms + fatigue, easy bruising, thirst,
cramps, skin color changes, making
if not currently bleeding initiate cyclic OCP- medroxyprogesterone acetate or
norethindrone acetate
,if currently bleeding use taper method of monophasic OCPs to stop bleeding
Provide antiemetic to decrease nausea- promethazine
If estrogen is contraindicated use norethindrone acetate 5-10 mg daily
Severe AUB tx - ANSWER ✓ Prolonged, heavy flow, anemia Hgb <9
If hgb <7 or orthostasis is present admit to hopsital, obtain clotting studies and
thyroid panel
if hgb 8-10 can tx at home with tapering OCPs (30mg ethinyl estradiol/o.3 mg
norgestrel) use every 4 hours until bleeding slows/stops
Iron supplementation, treat for nausea as needed
NSAIDs for AUB - ANSWER ✓ Ibuprofen
Flurbiprofen
Meclofenamate sodium
Mefenamic acid
Naproxen sodium
Antifibrinolytics for AUG - ANSWER ✓ aminocaproic acid
tranexamic acid
Hormonal devices for AUB - ANSWER ✓ Levonorgestrel IUD
Etonogestrel/ethinyl estradiol vaginal ring
Norelgestromin/ethinyl estradiol transdermal patch
Hormonal progestogens for AUB - ANSWER ✓ Medroxyprogesterone
Micronized progesterone
Etonogestrel
Norethindrone acetate
Nortethindrone
Hormonal Combined OCPS for AUB - ANSWER ✓ Ethinyl
estradiol/norethindrone/desogestrel/norgestimate etc
Estrogen contraindication examples - ANSWER ✓ Migraine with aura
Hypertension
Prior DVT/PE
Transplant
, Congenital cardiac anomalies
Increased risk for blood loss
When is peak height attained in girls? - ANSWER ✓ between 11.5-12yo
When is peak height in boys? - ANSWER ✓ Between 13.5-14yo, muscle mass
doubles between 10-17 yo
SMR stage 1 in females - ANSWER ✓ no breast development
no pubic hair
SMR stage 2 females - ANSWER ✓ first sign of breast development appears
brest budding
some palpable breast tissue under nipple, areola is somewhat enlarged
Small amount of long pubic hair
SMR stage 3 females - ANSWER ✓ breast more distinct, no separation between
contours of two breasts
hair is darker, coarser/curlier, spreads sparsely over
SMR stage 4 females - ANSWER ✓ breast further enlarged and greater contour
distinction, nipple including areola forms a secondary mound on breast
hair now adult in type; may cover smaller area, no pubic hair on inside of thighs
SMR stage 5 females - ANSWER ✓ breast size may vary in mature stage, breast
fully developed, contours distinct, areola has receded into general countour of breat
public hair inverted triangle pattern
SMR stage 1 males - ANSWER ✓ penis/scrotum infantile state; increase slightly
in size but little change in overall appearance
no true pubic hair
SMR stage 2 males - ANSWER ✓ scrotum begins to enlarge, some
reddening/change in scrotal skin
sparse growth of lightly pigmented pubic hair. Usually straight and only slightly
curly