NR 507 EDAPT DEMYELINATING DISEASES QUESTIONS
WITH CORRECT ANSWERS Pass 100%|120+ Verified
Questions \Answer:
Exam: Demyelinating Diseases (NR 507 EDAPT Style)
Section 1: Pathophysiology & Basic Concepts (Questions 1–20)
1. Which of the following best defines demyelination?
A. Destruction of the neuronal cell body
B. Loss of the myelin sheath around axons
C. Degeneration of the axon without myelin involvement
D. Proliferation of oligodendrocytes
Currect Answer: B
Rationale: Demyelination specifically refers to damage or loss of the myelin sheath that
insulates nerve axons, leading to slowed or blocked nerve conduction.
2. In the CNS, myelin is produced by:
A. Schwann cells
B. Microglia
C. Oligodendrocytes
D. Astrocytes
Currect Answer: C
Rationale: Oligodendrocytes are the myelinating cells of the central nervous system (CNS).
Schwann cells myelinate peripheral nerves.
3. In the PNS, myelin is produced by:
A. Oligodendrocytes
B. Ependymal cells
C. Schwann cells
D. Microglia
Currect Answer: C
Rationale: Schwann cells wrap around peripheral nerve axons to form the myelin sheath.
,4. Which demyelinating disease primarily affects the CNS?
A. Guillain-Barré syndrome (GBS)
B. Chronic inflammatory demyelinating polyneuropathy (CIDP)
C. Multiple sclerosis (MS)
D. Charcot-Marie-Tooth disease
Currect Answer: C
Rationale: MS is an autoimmune demyelinating disease of the CNS. GBS and CIDP affect the
PNS.
5. Which demyelinating disease primarily affects the PNS?
A. Multiple sclerosis
B. Transverse myelitis
C. Guillain-Barré syndrome
D. Optic neuritis
Currect Answer: C
Rationale: GBS is an acute inflammatory demyelinating polyradiculoneuropathy affecting
peripheral nerves.
6. The characteristic pathologic finding in MS is:
A. Wallerian degeneration
B. Plaques (sclerosis) in the CNS
C. Axonal spheroids
D. Lewy bodies
Currect Answer: B
Rationale: MS is characterized by multiple areas of demyelination (plaques) in the brain and
spinal cord.
7. In MS, which immune cells are primarily involved in myelin attack?
A. B cells only
B. CD8+ T cells only
C. Autoreactive CD4+ T cells and macrophages
D. Neutrophils
Currect Answer: C
Rationale: Autoreactive CD4+ T cells cross the blood-brain barrier, activate macrophages,
and attack myelin.
, 8. Which of the following is NOT a typical trigger for GBS?
A. Campylobacter jejuni infection
B. Influenza vaccination
C. Cytomegalovirus infection
D. Staphylococcus aureus bacteremia
Currect Answer: D
Rationale: GBS is often preceded by C. jejuni, CMV, EBV, or influenza vaccination. S. aureus is
not a common trigger.
9. The hallmark clinical feature of demyelinating diseases is:
A. Constant severe pain
B. Rapidly progressive dementia
C. Relapsing-remitting neurologic deficits
D. Unilateral weakness only
Currect Answer: C
Rationale: Many demyelinating diseases, especially MS, present with relapsing-remitting
episodes of neurologic dysfunction.
10. In MS, remyelination can occur but is often incomplete due to:
A. Lack of Schwann cells in CNS
B. Failure of oligodendrocyte precursor cell differentiation
C. Excessive astrocyte apoptosis
D. Overproduction of BDNF
Currect Answer: B
Rationale: Oligodendrocyte precursor cells may fail to mature, limiting effective
remyelination.
11. Which ion channel dysfunction contributes to symptoms in demyelinated axons?
A. Sodium channel redistribution
B. Potassium channel blockade
C. Calcium channel overexpression
D. Chloride channel inactivation
Currect Answer: A
Rationale: Sodium channels redistribute along demyelinated axons, leading to ectopic
impulses and conduction blocks.
WITH CORRECT ANSWERS Pass 100%|120+ Verified
Questions \Answer:
Exam: Demyelinating Diseases (NR 507 EDAPT Style)
Section 1: Pathophysiology & Basic Concepts (Questions 1–20)
1. Which of the following best defines demyelination?
A. Destruction of the neuronal cell body
B. Loss of the myelin sheath around axons
C. Degeneration of the axon without myelin involvement
D. Proliferation of oligodendrocytes
Currect Answer: B
Rationale: Demyelination specifically refers to damage or loss of the myelin sheath that
insulates nerve axons, leading to slowed or blocked nerve conduction.
2. In the CNS, myelin is produced by:
A. Schwann cells
B. Microglia
C. Oligodendrocytes
D. Astrocytes
Currect Answer: C
Rationale: Oligodendrocytes are the myelinating cells of the central nervous system (CNS).
Schwann cells myelinate peripheral nerves.
3. In the PNS, myelin is produced by:
A. Oligodendrocytes
B. Ependymal cells
C. Schwann cells
D. Microglia
Currect Answer: C
Rationale: Schwann cells wrap around peripheral nerve axons to form the myelin sheath.
,4. Which demyelinating disease primarily affects the CNS?
A. Guillain-Barré syndrome (GBS)
B. Chronic inflammatory demyelinating polyneuropathy (CIDP)
C. Multiple sclerosis (MS)
D. Charcot-Marie-Tooth disease
Currect Answer: C
Rationale: MS is an autoimmune demyelinating disease of the CNS. GBS and CIDP affect the
PNS.
5. Which demyelinating disease primarily affects the PNS?
A. Multiple sclerosis
B. Transverse myelitis
C. Guillain-Barré syndrome
D. Optic neuritis
Currect Answer: C
Rationale: GBS is an acute inflammatory demyelinating polyradiculoneuropathy affecting
peripheral nerves.
6. The characteristic pathologic finding in MS is:
A. Wallerian degeneration
B. Plaques (sclerosis) in the CNS
C. Axonal spheroids
D. Lewy bodies
Currect Answer: B
Rationale: MS is characterized by multiple areas of demyelination (plaques) in the brain and
spinal cord.
7. In MS, which immune cells are primarily involved in myelin attack?
A. B cells only
B. CD8+ T cells only
C. Autoreactive CD4+ T cells and macrophages
D. Neutrophils
Currect Answer: C
Rationale: Autoreactive CD4+ T cells cross the blood-brain barrier, activate macrophages,
and attack myelin.
, 8. Which of the following is NOT a typical trigger for GBS?
A. Campylobacter jejuni infection
B. Influenza vaccination
C. Cytomegalovirus infection
D. Staphylococcus aureus bacteremia
Currect Answer: D
Rationale: GBS is often preceded by C. jejuni, CMV, EBV, or influenza vaccination. S. aureus is
not a common trigger.
9. The hallmark clinical feature of demyelinating diseases is:
A. Constant severe pain
B. Rapidly progressive dementia
C. Relapsing-remitting neurologic deficits
D. Unilateral weakness only
Currect Answer: C
Rationale: Many demyelinating diseases, especially MS, present with relapsing-remitting
episodes of neurologic dysfunction.
10. In MS, remyelination can occur but is often incomplete due to:
A. Lack of Schwann cells in CNS
B. Failure of oligodendrocyte precursor cell differentiation
C. Excessive astrocyte apoptosis
D. Overproduction of BDNF
Currect Answer: B
Rationale: Oligodendrocyte precursor cells may fail to mature, limiting effective
remyelination.
11. Which ion channel dysfunction contributes to symptoms in demyelinated axons?
A. Sodium channel redistribution
B. Potassium channel blockade
C. Calcium channel overexpression
D. Chloride channel inactivation
Currect Answer: A
Rationale: Sodium channels redistribute along demyelinated axons, leading to ectopic
impulses and conduction blocks.
