1|Page
WGU D116 ADVANCED PHARMACOLOGY OA AND PRE
ASSESSMENT EXAM NEWEST 2026/2027 ACTUAL EXAM
WITH COMPLETE QUESTIONS AND CORRECT DETAILED
ANSWERS (100% VERIFIED ANSWERS) |ALREADY
GRADED A+
A patient presents to an emergency room complaining of palpitations
and irregular heartbeat. The APRN places the patient on a cardiac
monitor and observes atrial fibrillation. The APRN orders dofetilide.
How should the APRN recommend this medication be taken?
......ANSWER......YES With food or an empty stomach
A 70-year-old male calls a clinic complaining of chest pain that started
after sexual activity. He took sildenafil 50 mg about eight hours ago. He
has nitroglycerin 0.3 mg on hand. How should the APRN respond?
......ANSWER......Do not take the nitroglycerin and call 911
Taking the medications together can cause what? ......ANSWER......A
serious drop in blood pressure leading to cardiovascular collapse.
A patient with bipolar disorder is discussing beginning lithium. The
APRN wants baseline labs. The patient asks why. Which explanation
should be provided? ......ANSWER......A baseline BUN and creatinine is
needed to assess kidney function because lithium can decrease renal
function.
pg. 1
,2|Page
A new nurse is reviewing sildenafil use. Which patient may take
sildenafil safely? ......ANSWER......YES A 54-year-old male with
controlled hypertension, mild eczema, and past urolithiasis without
complications
A 30-year-old patient with anxiety is prescribed citalopram. What is its
mechanism of action? ......ANSWER......YES Influences receptor activity
on target cells
Correct explanation of citalopram's mechanism ......ANSWER......This
medication influences the activity in the receptors, and it targets cells.
A Huntington disease patient has twitching, dysphagia, confusion,
memory loss. APRN prescribes baclofen. Mechanism of action?
......ANSWER......YES Inhibits neurotransmitter GABA
NO Modulates the effects of glutamate at NMDA receptors
......ANSWER......Incorrect.
NO Halts breakdown of acetylcholine by acetylcholinesterase
......ANSWER......Incorrect. Cholinesterase inhibitors prevent ACh
breakdown and are used for Alzheimer's.
pg. 2
,3|Page
Alters synthesis and release of norepinephrine, serotonin, and
dopamine ......ANSWER......Incorrect.
Correct explanation ......ANSWER......Baclofen enhances GABA;
Huntington involves deficiency of acetylcholine and GABA.
A 21-year-old patient has a seizure with impaired consciousness
followed by CNS depression. Type of seizure? ......ANSWER......YES
Tonic-clonic
A patient taking oxycodone every 6 hrs for 3 years suddenly stops. What
is the clinical concern? ......ANSWER......YES Physical dependence
Correct explanation ......ANSWER......Stopping abruptly causes
withdrawal and can cause symptoms from nausea to seizures.
A 44-year-old male with depression and sexual dysfunction history
needs an antidepressant that enhances libido. ......ANSWER......YES
Bupropion
Explanation ......ANSWER......Bupropion does not cause sexual
dysfunction and may improve libido.
pg. 3
, 4|Page
A wheezing patient receives a nonspecific beta-agonist. Besides
respiratory relief, what side effect should the nurse monitor?
......ANSWER......YES Tachycardia
Explanation ......ANSWER......Beta1 stimulation causes tachycardia and
hypertension.
A patient has toxic atropine effects (delirium, hallucinations). Which
medication should the provider administer? ......ANSWER......YES
Physostigmine
Explanation ......ANSWER......Physostigmine treats atropine poisoning
and crosses the BBB.
A patient requires sutures. Provider orders local anesthetic with
epinephrine. Epinephrine is used to ________. ......ANSWER......Allow a
reduced dose of the anesthetic
Explanation ......ANSWER......Epinephrine (alpha1 agonist) prolongs
absorption and reduces anesthetic needed.
A Parkinson patient on carbidopa reports no change after months. What
should the provider do? ......ANSWER......Reevaluate the diagnosis
Increase the dose of carbidopa ......ANSWER......Option but less correct
pg. 4
WGU D116 ADVANCED PHARMACOLOGY OA AND PRE
ASSESSMENT EXAM NEWEST 2026/2027 ACTUAL EXAM
WITH COMPLETE QUESTIONS AND CORRECT DETAILED
ANSWERS (100% VERIFIED ANSWERS) |ALREADY
GRADED A+
A patient presents to an emergency room complaining of palpitations
and irregular heartbeat. The APRN places the patient on a cardiac
monitor and observes atrial fibrillation. The APRN orders dofetilide.
How should the APRN recommend this medication be taken?
......ANSWER......YES With food or an empty stomach
A 70-year-old male calls a clinic complaining of chest pain that started
after sexual activity. He took sildenafil 50 mg about eight hours ago. He
has nitroglycerin 0.3 mg on hand. How should the APRN respond?
......ANSWER......Do not take the nitroglycerin and call 911
Taking the medications together can cause what? ......ANSWER......A
serious drop in blood pressure leading to cardiovascular collapse.
A patient with bipolar disorder is discussing beginning lithium. The
APRN wants baseline labs. The patient asks why. Which explanation
should be provided? ......ANSWER......A baseline BUN and creatinine is
needed to assess kidney function because lithium can decrease renal
function.
pg. 1
,2|Page
A new nurse is reviewing sildenafil use. Which patient may take
sildenafil safely? ......ANSWER......YES A 54-year-old male with
controlled hypertension, mild eczema, and past urolithiasis without
complications
A 30-year-old patient with anxiety is prescribed citalopram. What is its
mechanism of action? ......ANSWER......YES Influences receptor activity
on target cells
Correct explanation of citalopram's mechanism ......ANSWER......This
medication influences the activity in the receptors, and it targets cells.
A Huntington disease patient has twitching, dysphagia, confusion,
memory loss. APRN prescribes baclofen. Mechanism of action?
......ANSWER......YES Inhibits neurotransmitter GABA
NO Modulates the effects of glutamate at NMDA receptors
......ANSWER......Incorrect.
NO Halts breakdown of acetylcholine by acetylcholinesterase
......ANSWER......Incorrect. Cholinesterase inhibitors prevent ACh
breakdown and are used for Alzheimer's.
pg. 2
,3|Page
Alters synthesis and release of norepinephrine, serotonin, and
dopamine ......ANSWER......Incorrect.
Correct explanation ......ANSWER......Baclofen enhances GABA;
Huntington involves deficiency of acetylcholine and GABA.
A 21-year-old patient has a seizure with impaired consciousness
followed by CNS depression. Type of seizure? ......ANSWER......YES
Tonic-clonic
A patient taking oxycodone every 6 hrs for 3 years suddenly stops. What
is the clinical concern? ......ANSWER......YES Physical dependence
Correct explanation ......ANSWER......Stopping abruptly causes
withdrawal and can cause symptoms from nausea to seizures.
A 44-year-old male with depression and sexual dysfunction history
needs an antidepressant that enhances libido. ......ANSWER......YES
Bupropion
Explanation ......ANSWER......Bupropion does not cause sexual
dysfunction and may improve libido.
pg. 3
, 4|Page
A wheezing patient receives a nonspecific beta-agonist. Besides
respiratory relief, what side effect should the nurse monitor?
......ANSWER......YES Tachycardia
Explanation ......ANSWER......Beta1 stimulation causes tachycardia and
hypertension.
A patient has toxic atropine effects (delirium, hallucinations). Which
medication should the provider administer? ......ANSWER......YES
Physostigmine
Explanation ......ANSWER......Physostigmine treats atropine poisoning
and crosses the BBB.
A patient requires sutures. Provider orders local anesthetic with
epinephrine. Epinephrine is used to ________. ......ANSWER......Allow a
reduced dose of the anesthetic
Explanation ......ANSWER......Epinephrine (alpha1 agonist) prolongs
absorption and reduces anesthetic needed.
A Parkinson patient on carbidopa reports no change after months. What
should the provider do? ......ANSWER......Reevaluate the diagnosis
Increase the dose of carbidopa ......ANSWER......Option but less correct
pg. 4
