NURS 6024 PHARM EXAM 1 QUESTIONS WITH
VERIFIED ANSWERS
Having a DEA makes it so an APN can - ANSWER prescribe
controlled/scheduled drugs
Schedule 1 drugs - ANSWER Only research, high potential for abuse, not
medically useful
Schedule 2 drugs - ANSWER High potential for abuse and have medical use with
severe restrictions
Schedule 3 drugs - ANSWER Less potential for abuse and currently accepted
medical use
Schedule 4 drugs - ANSWER drugs with a low potential for abuse and low risk of
dependence
Schedule 5 drugs - ANSWER low abuse potential; no prescription needed for
adults over the age of 18
What are databases useful for when prescribing scheduled drugs - ANSWER
Help know what other prescriptions have been prescribed to patient
ADME pertains to - ANSWER pharmacokinetics
ADME stands for - ANSWER Absorption
Distribution
Metabolism
Excretion
______ is the the drugs interactions within the body tissues. - ANSWER
Pharmacodynamics
Variability in drug response is due to _______. - ANSWER Pharmacogenetics
______ is the development and use of medications based on pharmacogenetics -
ANSWER Pharmacogenomics
Absorption is from site of administration to _______ - ANSWER the blood stream
,Distribution is - ANSWER carrying to drugs site of action and reacting w/
receptor
Elimination happens through (2) - ANSWER kidneys
feces
Water soluble cannot/can pass through cell membranes - ANSWER cannot
Lipid soluble cannot/can pass through cell membranes - ANSWER can
Which is more likely to pass through the BBB, lipid or water soluble? - ANSWER
Lipid
Weak acid drug in acid media is (ionized/nonionized) and (more/less) likely to
produce desired effect. - ANSWER nonionized; more
Weak acid drug in basic media is (ionized/nonionized) and (more/less) likely to
produce desired effect. - ANSWER ionized; less
Weak basic drug in acid media is (ionized/nonionized) and (more/less) likely to
produce desired effect. - ANSWER Ionized; less
Weak basic drug in basic media is (ionized/nonionized) and (more/less) likely to
produce desired effect. - ANSWER nonionized; more
Drugs are best absorbed in (ionized/nonionized) (water-soluble/lipid-soluble)
form. - ANSWER nonionized; lipid soluble
Cytochrome p450 enzymes are found primarily in the _____. They also can be
found in _____ (2) - ANSWER liver
lungs; intestines
Grapejuice is an inhibitor making warfarin (increase/decrease) in the blood
stream. - ANSWER Increase
Rifampin is an inducer of cytochrome p450. A pt taking warfarin and starts
rifampin will be at risk for (hemorrhage/clots). - ANSWER Clots
Cockroft gault equation calculates - ANSWER CrCl
How is a prodrug activated? - ANSWER Metabolized in the liver
When a drug is metabolized, it is (inactivated/activated) except in the case of
______ where the opposite is true. - ANSWER inactivated; prodrugs
Zero order elimination has a (curved/straight) graph - ANSWER straight
, First order elimination has a (curved/straight) graph - ANSWER curved
A constant proportion of the drug is eliminated at a time in _________ - ANSWER
First-order elimination
A constant amount per unit of time is metabolized in ________. - ANSWER Zero-
order elimination
Which has a simple equation (multiply x2) to double a dose?
Zero-order elimination
First-order elimination - ANSWER First-order elimination
Why might you not want to switch between certain drugs such as Lithium and
Phenytoin from brand to generic? - ANSWER Narrow therapeutic window. These
drugs could be slightly different and still be approved.
Pregnant women have _____ blood flow the kidneys making excretion
(accelerated/delayed) - ANSWER accelerated
In pregnancy there is (increase/decreased) hepatic metabolism - ANSWER
Increase
In pregnancy mobility of bowels (increase/decrease) and the amount of
absorption that can take places (increases/decreases). - ANSWER Decrease;
increases
In infants there are (less/more) albumin to bind to drugs - ANSWER less
In infants the BBB is (less/more) permeable - ANSWER more
Lipid soluble cannot/can pass through cell membranes - ANSWER can
all bacteria except _______ have a cell wall - ANSWER Mycoplasma
Gram neg have ___ protective layers. - ANSWER 3
Gram pos have ___ protective layers - ANSWER 2
Humans have a ___s ribosome - ANSWER 80
Ribosomes primary function - ANSWER tranlate mRNA to synthesize protein
4 antibiotic classes that are bacteriostatic - ANSWER Clindamycin
Tetracycline
Macrolides
VERIFIED ANSWERS
Having a DEA makes it so an APN can - ANSWER prescribe
controlled/scheduled drugs
Schedule 1 drugs - ANSWER Only research, high potential for abuse, not
medically useful
Schedule 2 drugs - ANSWER High potential for abuse and have medical use with
severe restrictions
Schedule 3 drugs - ANSWER Less potential for abuse and currently accepted
medical use
Schedule 4 drugs - ANSWER drugs with a low potential for abuse and low risk of
dependence
Schedule 5 drugs - ANSWER low abuse potential; no prescription needed for
adults over the age of 18
What are databases useful for when prescribing scheduled drugs - ANSWER
Help know what other prescriptions have been prescribed to patient
ADME pertains to - ANSWER pharmacokinetics
ADME stands for - ANSWER Absorption
Distribution
Metabolism
Excretion
______ is the the drugs interactions within the body tissues. - ANSWER
Pharmacodynamics
Variability in drug response is due to _______. - ANSWER Pharmacogenetics
______ is the development and use of medications based on pharmacogenetics -
ANSWER Pharmacogenomics
Absorption is from site of administration to _______ - ANSWER the blood stream
,Distribution is - ANSWER carrying to drugs site of action and reacting w/
receptor
Elimination happens through (2) - ANSWER kidneys
feces
Water soluble cannot/can pass through cell membranes - ANSWER cannot
Lipid soluble cannot/can pass through cell membranes - ANSWER can
Which is more likely to pass through the BBB, lipid or water soluble? - ANSWER
Lipid
Weak acid drug in acid media is (ionized/nonionized) and (more/less) likely to
produce desired effect. - ANSWER nonionized; more
Weak acid drug in basic media is (ionized/nonionized) and (more/less) likely to
produce desired effect. - ANSWER ionized; less
Weak basic drug in acid media is (ionized/nonionized) and (more/less) likely to
produce desired effect. - ANSWER Ionized; less
Weak basic drug in basic media is (ionized/nonionized) and (more/less) likely to
produce desired effect. - ANSWER nonionized; more
Drugs are best absorbed in (ionized/nonionized) (water-soluble/lipid-soluble)
form. - ANSWER nonionized; lipid soluble
Cytochrome p450 enzymes are found primarily in the _____. They also can be
found in _____ (2) - ANSWER liver
lungs; intestines
Grapejuice is an inhibitor making warfarin (increase/decrease) in the blood
stream. - ANSWER Increase
Rifampin is an inducer of cytochrome p450. A pt taking warfarin and starts
rifampin will be at risk for (hemorrhage/clots). - ANSWER Clots
Cockroft gault equation calculates - ANSWER CrCl
How is a prodrug activated? - ANSWER Metabolized in the liver
When a drug is metabolized, it is (inactivated/activated) except in the case of
______ where the opposite is true. - ANSWER inactivated; prodrugs
Zero order elimination has a (curved/straight) graph - ANSWER straight
, First order elimination has a (curved/straight) graph - ANSWER curved
A constant proportion of the drug is eliminated at a time in _________ - ANSWER
First-order elimination
A constant amount per unit of time is metabolized in ________. - ANSWER Zero-
order elimination
Which has a simple equation (multiply x2) to double a dose?
Zero-order elimination
First-order elimination - ANSWER First-order elimination
Why might you not want to switch between certain drugs such as Lithium and
Phenytoin from brand to generic? - ANSWER Narrow therapeutic window. These
drugs could be slightly different and still be approved.
Pregnant women have _____ blood flow the kidneys making excretion
(accelerated/delayed) - ANSWER accelerated
In pregnancy there is (increase/decreased) hepatic metabolism - ANSWER
Increase
In pregnancy mobility of bowels (increase/decrease) and the amount of
absorption that can take places (increases/decreases). - ANSWER Decrease;
increases
In infants there are (less/more) albumin to bind to drugs - ANSWER less
In infants the BBB is (less/more) permeable - ANSWER more
Lipid soluble cannot/can pass through cell membranes - ANSWER can
all bacteria except _______ have a cell wall - ANSWER Mycoplasma
Gram neg have ___ protective layers. - ANSWER 3
Gram pos have ___ protective layers - ANSWER 2
Humans have a ___s ribosome - ANSWER 80
Ribosomes primary function - ANSWER tranlate mRNA to synthesize protein
4 antibiotic classes that are bacteriostatic - ANSWER Clindamycin
Tetracycline
Macrolides
