Glycolysis and Its Importance
Dr. Endriyas Kelta (DMD, MSc)
Assistant Professor, AAU
,Glycolysis
– Also called Embden-Meyerhof Pathway
– Series of enzyme-catalyzed reaction pathway
• Glucose is oxidized into pyruvate
– Takes place in cytosol of all cells
– Major pathway for glucose utilization
– Unique pathway
• Functional both in the presence & absence of oxygen
– Universal central pathway of glucose catabolism
in all forms of life
• Differs by means of regulation & fate of pyruvate
– Free energy released is captured in the form of
ATP and NADH
2
,Fates of Pyruvate 3
, Cont…
• Glycolysis takes place in two phases:
– Preparatory Phase
• Consists of 1st five reaction steps
• One molecule of glucose is starting material
• Two molecules of Glyceraldehyde 3-phosphates
are end products
• Two molecules of ATP are invested
– Payoff phase
• Consists of 2nd five reaction steps
• Two molecules of Glyceraldehyde 3-phosphates
are starting materials
• Two molecules of pyruvates are end products
• Four molecules of ATP & 2 molecules of NADH +
H+ are conserved 4
Dr. Endriyas Kelta (DMD, MSc)
Assistant Professor, AAU
,Glycolysis
– Also called Embden-Meyerhof Pathway
– Series of enzyme-catalyzed reaction pathway
• Glucose is oxidized into pyruvate
– Takes place in cytosol of all cells
– Major pathway for glucose utilization
– Unique pathway
• Functional both in the presence & absence of oxygen
– Universal central pathway of glucose catabolism
in all forms of life
• Differs by means of regulation & fate of pyruvate
– Free energy released is captured in the form of
ATP and NADH
2
,Fates of Pyruvate 3
, Cont…
• Glycolysis takes place in two phases:
– Preparatory Phase
• Consists of 1st five reaction steps
• One molecule of glucose is starting material
• Two molecules of Glyceraldehyde 3-phosphates
are end products
• Two molecules of ATP are invested
– Payoff phase
• Consists of 2nd five reaction steps
• Two molecules of Glyceraldehyde 3-phosphates
are starting materials
• Two molecules of pyruvates are end products
• Four molecules of ATP & 2 molecules of NADH +
H+ are conserved 4
