UNIT 2
BIGLOGY 1O 1
, PROTEIN FUNCTIONS - LECTURE ZA
each w/
human
body
has
specific function
-30 , 000
protins
*
a
human
bady
* 16 %
of from prolm
-
mass
“
cames
versatile
~ entimely
↳
himaglobin : cavius O2
from lungs to tissue
CO2 to
lungs fas umanal+
} Bremente
teinsttnet
>
↳
hysoyyme : claves cell wall molecules w/non cavalent interactions e
microtubul cell division
↳ tubulin :
fame for
↳ insulin allows to be used
glease far energy
:
WHAT DO PROTEINS DO ?
ENZYMES chemical reactions small molecules
speed up
· -
> TRANSPORT -
catalyze chanical
reactions
·
(after make/break covalent hand) ·
transport within cells as across membrane
specific molecule transported from
⇌
(ex Leaks hand specific to
·
sugular
is
specific far singular molcule) and
·
are a
a source
·
.
a
biology requires
a
specific distration
'
EVERY reachan in …
·
an (thousands used)
enzyme
Gener tim
alls ↳
many transportie required
facity far complete deliveries
can efeacheyecause a
·
these
protis to cantral
regulated transport (an/off)
·
on
se
↳
me conditions all chuncal reactions regulated
so
catalyst needed
far
,
each
different reaction .
as
pretty slaw
,
EXAMPLE : HEMOGLOBIN
E XANIPLE: LYSOZYME subrinit small malcula
↓
~
kraken 'humes'
wand hysazyme Linds
agen
in
lungs on
·
← ·
binds to substrate wall
specific
·
protim travels through bland
substrate :
lysozymes polyous making up cell
·
releases this tissues
·
in
anygen
perifichand itssubstrat
Luck
fleft
in
·an ·
ONLY CARRIES O2
-enid RELIES an BLOOD
·
espects EVERY 0 5 seconds &
tuchiequatirary
.
^
·
tactical
cell bursts and dies
small molecules
! larger
.
ㄻ
substrat
actical a
polyemaking mechanic
a
daing mechanical nack
· -
STRUCTURE machines
forming rigid polynes MOLECULAR MOTORS
: :
example Kinesin malks' microtubules to transport
along
EXAMPLE: TUBULIN
·
:
as momr
vescale
X-tubilu + B-tubular Find to eachother
full of small malrcules to other
parts of the
Spolypep
·
this structure cell
polymerizes to create
·
^
spiral structur : MICROTUBULE
tubula
sum ↑ → icrotubules
·
can to extensive +
B-lubulin
⇌
-
compase the
cylasttitan-giving
"
}Polypep ↑ shope -rigiity w/ vast netuark
aell
Motor
·
protius must pull these
'
SIGNAL TRANSDUCTION : dilect,
_
bransfarm S transmit info
lacaton
rigid structures information
-
Ebmlisstructure mi :
ratebule
reharug
whrueri
HOLLOW _
> EXAMPLE : CELL SURFACE RECEPTORS opes
thind fgpis
grawth factors ~ missingers
released of
Are
complex than
fruit fly ?
growth factors trigger cells to divide
·
macs
you
a
smallon
-
·
growth factor binding to factor receptor causes
↳ while have extracellulas it to
-38 000
protis flie have -20, 000
different diergs (conformation change)
…
we , ones
,
intracellular binds attee
protes to
·
2 - helix >
-
cellmunhrane part now
bugger cell division
_
(ACTIVATED)
voceasing growth factor receptor signaling
· mutations
Cancer
} ↳achie →
KEY CONCEPTS
1) The ilres dimensional
:
structure
epidematte
e
fac ishimir
determine its
of a
protei function
2)
protines carry out
amazing varity of functions an
3) each
protin carries out citamely specific function
one
4) thus
many
thousands
of protes
,
required far life
are
「」
BIGLOGY 1O 1
, PROTEIN FUNCTIONS - LECTURE ZA
each w/
human
body
has
specific function
-30 , 000
protins
*
a
human
bady
* 16 %
of from prolm
-
mass
“
cames
versatile
~ entimely
↳
himaglobin : cavius O2
from lungs to tissue
CO2 to
lungs fas umanal+
} Bremente
teinsttnet
>
↳
hysoyyme : claves cell wall molecules w/non cavalent interactions e
microtubul cell division
↳ tubulin :
fame for
↳ insulin allows to be used
glease far energy
:
WHAT DO PROTEINS DO ?
ENZYMES chemical reactions small molecules
speed up
· -
> TRANSPORT -
catalyze chanical
reactions
·
(after make/break covalent hand) ·
transport within cells as across membrane
specific molecule transported from
⇌
(ex Leaks hand specific to
·
sugular
is
specific far singular molcule) and
·
are a
a source
·
.
a
biology requires
a
specific distration
'
EVERY reachan in …
·
an (thousands used)
enzyme
Gener tim
alls ↳
many transportie required
facity far complete deliveries
can efeacheyecause a
·
these
protis to cantral
regulated transport (an/off)
·
on
se
↳
me conditions all chuncal reactions regulated
so
catalyst needed
far
,
each
different reaction .
as
pretty slaw
,
EXAMPLE : HEMOGLOBIN
E XANIPLE: LYSOZYME subrinit small malcula
↓
~
kraken 'humes'
wand hysazyme Linds
agen
in
lungs on
·
← ·
binds to substrate wall
specific
·
protim travels through bland
substrate :
lysozymes polyous making up cell
·
releases this tissues
·
in
anygen
perifichand itssubstrat
Luck
fleft
in
·an ·
ONLY CARRIES O2
-enid RELIES an BLOOD
·
espects EVERY 0 5 seconds &
tuchiequatirary
.
^
·
tactical
cell bursts and dies
small molecules
! larger
.
ㄻ
substrat
actical a
polyemaking mechanic
a
daing mechanical nack
· -
STRUCTURE machines
forming rigid polynes MOLECULAR MOTORS
: :
example Kinesin malks' microtubules to transport
along
EXAMPLE: TUBULIN
·
:
as momr
vescale
X-tubilu + B-tubular Find to eachother
full of small malrcules to other
parts of the
Spolypep
·
this structure cell
polymerizes to create
·
^
spiral structur : MICROTUBULE
tubula
sum ↑ → icrotubules
·
can to extensive +
B-lubulin
⇌
-
compase the
cylasttitan-giving
"
}Polypep ↑ shope -rigiity w/ vast netuark
aell
Motor
·
protius must pull these
'
SIGNAL TRANSDUCTION : dilect,
_
bransfarm S transmit info
lacaton
rigid structures information
-
Ebmlisstructure mi :
ratebule
reharug
whrueri
HOLLOW _
> EXAMPLE : CELL SURFACE RECEPTORS opes
thind fgpis
grawth factors ~ missingers
released of
Are
complex than
fruit fly ?
growth factors trigger cells to divide
·
macs
you
a
smallon
-
·
growth factor binding to factor receptor causes
↳ while have extracellulas it to
-38 000
protis flie have -20, 000
different diergs (conformation change)
…
we , ones
,
intracellular binds attee
protes to
·
2 - helix >
-
cellmunhrane part now
bugger cell division
_
(ACTIVATED)
voceasing growth factor receptor signaling
· mutations
Cancer
} ↳achie →
KEY CONCEPTS
1) The ilres dimensional
:
structure
epidematte
e
fac ishimir
determine its
of a
protei function
2)
protines carry out
amazing varity of functions an
3) each
protin carries out citamely specific function
one
4) thus
many
thousands
of protes
,
required far life
are
「」
