UNITS
BIOLOGY 1O 1
, REGULATION OF GENE EXPRESSION
-
LECTURE SA
respond generate different types of
cells to the to
KEY CONCEPT 1 :
gens expression
is
regulated to allow to environment and
cells
regulated by regulating transcription of le
PROTEINS CAN BE : - its mRNA
ytasbelhon protin
all structure
-os capis
ex in
f
o
,
per
.
expressed alway especial
constitutely
:
raditions - aald induced
o a
↳ GENOME (-20 , 000
genes)subset
present in all
ENTIRE
very
↳ but each cell
type expresses of ganes
~ prokaryates
bacteria
The las
operan
E
of colis provides . classic
example of regulated give expression in
backna
-
sugas found food
eadedpestitijmintati e
feeds
in
↳
glucase
: main >
-
↳ lactase : main milk in smed
( eugas
↳
three
enzymes
buch down lactase ,
meaded all in one mRNA
Ly lac e
transcribed
a promoter
by
~
guss 咽
:
sm β lacate
is
brA
:
aperan
wenk oAR
induced
by high
levels
of lactase
>
↳
-
aperator
can digest
↓
finish
t of
no lactase >
-
repressa priate
aman no
eyes
REGULATION
of
the E cali las
.
operon
DNA
yes
lactase- > lastase Linds to
it
changes
repressor
a polymerate eut
but on
670 , subrinit finds
promolar
_
bactuial
of RNA
polymecase
·
-
physually alasbinding
go
binds
lac bluch
prolems
find
repressar
operator
·
When lactase DNA
presence of lactase NO REPRES O
·
=
absent) CAP then binds CAP site stimulates 00-Pol
CAP-catabolite activator Linds /made
only whe
transcription
>
protin at MP
ghecase
is
· >
-
& camnat bund
* CAMP is made that
enhances
glucase
=
no
enzyme transcorphan by binding 2 site
- -
lactass takes
~
it
camp
away
slackoa
fasse and
allowing 600pe to find to start
·
p
transit transcription
>
-
high cAMP high transcrption=
( of glucose signal
↳ absence
whee
binding facilitates
tancophon
gene transruption
REGULATION EUKARYOTIC
of
↳
general transcriptions factors play role
870
of
↳additional
gene-specific transcription factors help initiate
transcription
·
sams find near
promoter
ectuator enhance
DNA
sequences enhancing transcription if they are
·
others ,
transruptional protes ,
find near a
pramatar /up/down
stream) -so Kb
away
↳
type of transcriptional
daige
actuator
protein might dayens of gives
d
turn to coardinate
gene Impression
Trat
a re
on
hundreds
*
enhancer
of binding protins
thmas ugen
ces
⇌
each binds base the
specific in
of DNA
·
sequences majas grase
ithn upume
·
sucral
families of sequence specific INA
binding protis o ing
gae
>
-
typically stick helix in MAJOR
graar
! hydraphalic
intraction
心
BIOLOGY 1O 1
, REGULATION OF GENE EXPRESSION
-
LECTURE SA
respond generate different types of
cells to the to
KEY CONCEPT 1 :
gens expression
is
regulated to allow to environment and
cells
regulated by regulating transcription of le
PROTEINS CAN BE : - its mRNA
ytasbelhon protin
all structure
-os capis
ex in
f
o
,
per
.
expressed alway especial
constitutely
:
raditions - aald induced
o a
↳ GENOME (-20 , 000
genes)subset
present in all
ENTIRE
very
↳ but each cell
type expresses of ganes
~ prokaryates
bacteria
The las
operan
E
of colis provides . classic
example of regulated give expression in
backna
-
sugas found food
eadedpestitijmintati e
feeds
in
↳
glucase
: main >
-
↳ lactase : main milk in smed
( eugas
↳
three
enzymes
buch down lactase ,
meaded all in one mRNA
Ly lac e
transcribed
a promoter
by
~
guss 咽
:
sm β lacate
is
brA
:
aperan
wenk oAR
induced
by high
levels
of lactase
>
↳
-
aperator
can digest
↓
finish
t of
no lactase >
-
repressa priate
aman no
eyes
REGULATION
of
the E cali las
.
operon
DNA
yes
lactase- > lastase Linds to
it
changes
repressor
a polymerate eut
but on
670 , subrinit finds
promolar
_
bactuial
of RNA
polymecase
·
-
physually alasbinding
go
binds
lac bluch
prolems
find
repressar
operator
·
When lactase DNA
presence of lactase NO REPRES O
·
=
absent) CAP then binds CAP site stimulates 00-Pol
CAP-catabolite activator Linds /made
only whe
transcription
>
protin at MP
ghecase
is
· >
-
& camnat bund
* CAMP is made that
enhances
glucase
=
no
enzyme transcorphan by binding 2 site
- -
lactass takes
~
it
camp
away
slackoa
fasse and
allowing 600pe to find to start
·
p
transit transcription
>
-
high cAMP high transcrption=
( of glucose signal
↳ absence
whee
binding facilitates
tancophon
gene transruption
REGULATION EUKARYOTIC
of
↳
general transcriptions factors play role
870
of
↳additional
gene-specific transcription factors help initiate
transcription
·
sams find near
promoter
ectuator enhance
DNA
sequences enhancing transcription if they are
·
others ,
transruptional protes ,
find near a
pramatar /up/down
stream) -so Kb
away
↳
type of transcriptional
daige
actuator
protein might dayens of gives
d
turn to coardinate
gene Impression
Trat
a re
on
hundreds
*
enhancer
of binding protins
thmas ugen
ces
⇌
each binds base the
specific in
of DNA
·
sequences majas grase
ithn upume
·
sucral
families of sequence specific INA
binding protis o ing
gae
>
-
typically stick helix in MAJOR
graar
! hydraphalic
intraction
心
