Page 1 of 158
NSG 6006 PRACTICE QUESTIONS WITH
CORRECT ANSWERS GRADED A+ |VERIFIED
TO PASS
1. A patient with liver cirrhosis is prescribed a drug with
high first-pass metabolism. What change is most likely
needed?
• A) Increase the dose
• B) Decrease the dose
• C) No change
• D) Change route to IV
Answer: B
Rationale: Impaired liver function reduces first-pass
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metabolism, increasing bioavailability. Dose reduction
prevents toxicity.
2. Which statement best describes the blood-brain barrier?
• A) Allows all lipid-soluble drugs to pass
• B) Prevents all protein-bound drugs from entering
• C) Permits only water-soluble drugs
• D) Is fully developed at birth
Answer: A
Rationale: Lipid-soluble drugs cross the BBB easily; protein-
bound and large molecules do not.
3. A drug with a half-life of 4 hours is given intravenously.
How long until steady state is reached?
• A) 8 hours
• B) 12 hours
• C) 20 hours
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• D) 24 hours
Answer: C
*Rationale: Steady state = 4–5 half-lives → 4 × 5 = 20
hours.*
4. A patient has a drug level of 10 mg/L at 2 hours post-
dose and 2.5 mg/L at 8 hours post-dose. What is the
approximate half-life?
• A) 2 hours
• B) 3 hours
• C) 4 hours
• D) 6 hours
Answer: B
*Rationale: Drop from 10 → 5 (1 half-life) → 2.5 (2
half-lives) over 6 hours → 3 hours per half-life.*
5. Which factor most increases the volume of distribution of
a drug?
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• A) High water solubility
• B) High protein binding
• C) High lipid solubility
• D) Large molecular size
Answer: C
Rationale: Lipid-soluble drugs distribute into fatty tissues,
increasing Vd.
6. A renally impaired patient needs a drug excreted
unchanged by the kidneys. What change is required?
• A) Increase loading dose
• B) Decrease maintenance dose
• C) No change
• D) Increase frequency
Answer: B
Rationale: Maintenance dose must be reduced to match
reduced clearance.
NSG 6006 PRACTICE QUESTIONS WITH
CORRECT ANSWERS GRADED A+ |VERIFIED
TO PASS
1. A patient with liver cirrhosis is prescribed a drug with
high first-pass metabolism. What change is most likely
needed?
• A) Increase the dose
• B) Decrease the dose
• C) No change
• D) Change route to IV
Answer: B
Rationale: Impaired liver function reduces first-pass
,Page 2 of 158
metabolism, increasing bioavailability. Dose reduction
prevents toxicity.
2. Which statement best describes the blood-brain barrier?
• A) Allows all lipid-soluble drugs to pass
• B) Prevents all protein-bound drugs from entering
• C) Permits only water-soluble drugs
• D) Is fully developed at birth
Answer: A
Rationale: Lipid-soluble drugs cross the BBB easily; protein-
bound and large molecules do not.
3. A drug with a half-life of 4 hours is given intravenously.
How long until steady state is reached?
• A) 8 hours
• B) 12 hours
• C) 20 hours
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• D) 24 hours
Answer: C
*Rationale: Steady state = 4–5 half-lives → 4 × 5 = 20
hours.*
4. A patient has a drug level of 10 mg/L at 2 hours post-
dose and 2.5 mg/L at 8 hours post-dose. What is the
approximate half-life?
• A) 2 hours
• B) 3 hours
• C) 4 hours
• D) 6 hours
Answer: B
*Rationale: Drop from 10 → 5 (1 half-life) → 2.5 (2
half-lives) over 6 hours → 3 hours per half-life.*
5. Which factor most increases the volume of distribution of
a drug?
, Page 4 of 158
• A) High water solubility
• B) High protein binding
• C) High lipid solubility
• D) Large molecular size
Answer: C
Rationale: Lipid-soluble drugs distribute into fatty tissues,
increasing Vd.
6. A renally impaired patient needs a drug excreted
unchanged by the kidneys. What change is required?
• A) Increase loading dose
• B) Decrease maintenance dose
• C) No change
• D) Increase frequency
Answer: B
Rationale: Maintenance dose must be reduced to match
reduced clearance.
