APhA Immunization Exam UPDATED
Questions and CORRECT Answers
The National Vaccine Advisory Committee 2013 Standards for Adult Immunization Practice and the
2016 International Pharmaceutical Federation global report identify pharmacists as: - CORRECT
ANSWER - Integral to increasing vaccination rates
Under the direction of the U.S. Department of Health and Human Services, the Healthy People initiative
has identified the following as a goal for 2030: - CORRECT ANSWER - Increase the proportion
of persons who are vaccinated annually against seasonal influenza
Opportunities for Advocacy and Collaboration include: - CORRECT ANSWER - Membership in
state Immunization coalition to serve as an expert on policy and practice issues affecting pharmacy
Which of the following diseases have been eradicated worldwide, allowing vaccination to be
discontinued? - CORRECT ANSWER - Smallpox - eradicated in 1980 by WHO
Which of the following is one of the five guidelines identified by the APhA Board of Trustees in 2019 to
assist pharmacists in incorporating immunization activities into their practice? - CORRECT
ANSWER - Prevention, Partnership, Quality, Documentation and Empowerment
Active Immunity - CORRECT ANSWER - Long-term protection but takes 2 weeks to work
Innate Immunity - CORRECT ANSWER - Barrier defense mechanism
Adaptive Immunity - CORRECT ANSWER - Also known as acquired
Passive Immunity - CORRECT ANSWER - Antibodies from an external source
Antigens - CORRECT ANSWER - Evoke the immune response and bind to specific antibodies
,T/F: Vaccines contain antibodies which are recognized by the immune system. - CORRECT
ANSWER - False
What can a pharmacist do to reduce the risk of getting hepatitis B after exposure? - CORRECT
ANSWER - 1. Post-exposure prophylaxis is needed right away
2. Give both Hep B immune globulin (HBIG) and Hepatitis B vaccine
3. HBIG contains antibodies that provide immediate protection via passive immunity
4. When a person is fully vaccinated, the hepatitis B vaccine provides long-term protection.
Live Vaccines are: - CORRECT ANSWER - 1. Attenuated
2. Stimulates both humoral and cell-mediated immune response
3. May be interfered with by circulating antibodies
4. Not given to children less than 12 months of age due to presence of maternal antibodies
Inactivated Vaccines are: - CORRECT ANSWER - 1. Killed virus or bacteria
2. Does not replicate
3. Stimulates humoral immunity (antibodies)
4. May be given to people who have received blood products or live vaccines, regardless of timing.
5. Predominantly given to infants (less than 12 months) because they may have circulating maternal
antibodies which could reduce the effectiveness of a live vaccines.
T/F: Inactivated vaccines do NOT have minimum intervals between administered vaccines - CORRECT
ANSWER - True
T/F: Inactivated vaccines are not affected by live vaccines and visa versa. - CORRECT ANSWER -
True
If two live vaccines are given simultaneously sly on the same day, then you must wait _____ minimum
interval. - CORRECT ANSWER - 28-day minimum interval so that each vaccine can replicate
properly.
,Live vaccines followed by blood products (contain antibodies) require ______minimum interval. -
CORRECT ANSWER - 2 weeks.
Which of the following is an example of passive immunity?
a.) Contracting measles
b.) Hep B Vaccine
c.) Skin Barrier
d.) Maternal antibodies - CORRECT ANSWER - d.) Maternal antibodies
Why is spacing and timing of vaccines important? - CORRECT ANSWER - Circulating antibodies
may interfere with immune response
How long does it take for the immune system to provide protection by producing disease-specific
antibodies and memory cells? - CORRECT ANSWER - 14 days
When does Active Immunity occur? - CORRECT ANSWER - When a patient is exposed to an
antigen that triggers the body's immune system to produce it's own disease-specific antibodies and
memory cells.
Children less than what age do not mount an adequate immune response to t-cell independent immunity? -
CORRECT ANSWER - 2 years.
Which of the following is found in vaccines to evoke an immune response? - CORRECT
ANSWER - Antigens
What does attenuated mean? - CORRECT ANSWER - weakened
LAIV4 is the abbreviation for: - CORRECT ANSWER - Live Attenuated Influenza Vaccine
RV1, RV5 is the abbreviation for: - CORRECT ANSWER - Rotavirus
, VAR is the abbreviation for: - CORRECT ANSWER - Varicella
MMR is the abbreviation for: - CORRECT ANSWER - Measles, mumps, rubella
MMRV is the abbreviation for: - CORRECT ANSWER - Measles, mumps, rubella, varicella
Can inactivated vaccines replicate? - CORRECT ANSWER - No. It does not cause disease.
What are two broad categories that vaccines are classified as? - CORRECT ANSWER - 1. Live
attenuated vaccines
2. Inactivated vaccines
Cellular Vaccines - CORRECT ANSWER - 1. Inactivated Vaccines
2. Whole viruses or bacteria
3. Known as Subunits (fractions)
4. DTP/DTaP
Toxoid Vaccines - CORRECT ANSWER - 1. Inactivated Vaccine
2. Subunit (fractions)
3. Inactive or biological toxin
4. Tetanus toxoid
Recombinant Vaccine - CORRECT ANSWER - 1. Produced by genetic engineering
2. May contain no actual virus or a modified strain of a virus
3. HepB, HPV, RZV, RIV4
What clinical factors need to be considered before administering a lie attenuated vaccine? - CORRECT
ANSWER - 1. Patients who currently are immunocompromised
2. Live attenuated vaccines administered in the previous 28 days.
Questions and CORRECT Answers
The National Vaccine Advisory Committee 2013 Standards for Adult Immunization Practice and the
2016 International Pharmaceutical Federation global report identify pharmacists as: - CORRECT
ANSWER - Integral to increasing vaccination rates
Under the direction of the U.S. Department of Health and Human Services, the Healthy People initiative
has identified the following as a goal for 2030: - CORRECT ANSWER - Increase the proportion
of persons who are vaccinated annually against seasonal influenza
Opportunities for Advocacy and Collaboration include: - CORRECT ANSWER - Membership in
state Immunization coalition to serve as an expert on policy and practice issues affecting pharmacy
Which of the following diseases have been eradicated worldwide, allowing vaccination to be
discontinued? - CORRECT ANSWER - Smallpox - eradicated in 1980 by WHO
Which of the following is one of the five guidelines identified by the APhA Board of Trustees in 2019 to
assist pharmacists in incorporating immunization activities into their practice? - CORRECT
ANSWER - Prevention, Partnership, Quality, Documentation and Empowerment
Active Immunity - CORRECT ANSWER - Long-term protection but takes 2 weeks to work
Innate Immunity - CORRECT ANSWER - Barrier defense mechanism
Adaptive Immunity - CORRECT ANSWER - Also known as acquired
Passive Immunity - CORRECT ANSWER - Antibodies from an external source
Antigens - CORRECT ANSWER - Evoke the immune response and bind to specific antibodies
,T/F: Vaccines contain antibodies which are recognized by the immune system. - CORRECT
ANSWER - False
What can a pharmacist do to reduce the risk of getting hepatitis B after exposure? - CORRECT
ANSWER - 1. Post-exposure prophylaxis is needed right away
2. Give both Hep B immune globulin (HBIG) and Hepatitis B vaccine
3. HBIG contains antibodies that provide immediate protection via passive immunity
4. When a person is fully vaccinated, the hepatitis B vaccine provides long-term protection.
Live Vaccines are: - CORRECT ANSWER - 1. Attenuated
2. Stimulates both humoral and cell-mediated immune response
3. May be interfered with by circulating antibodies
4. Not given to children less than 12 months of age due to presence of maternal antibodies
Inactivated Vaccines are: - CORRECT ANSWER - 1. Killed virus or bacteria
2. Does not replicate
3. Stimulates humoral immunity (antibodies)
4. May be given to people who have received blood products or live vaccines, regardless of timing.
5. Predominantly given to infants (less than 12 months) because they may have circulating maternal
antibodies which could reduce the effectiveness of a live vaccines.
T/F: Inactivated vaccines do NOT have minimum intervals between administered vaccines - CORRECT
ANSWER - True
T/F: Inactivated vaccines are not affected by live vaccines and visa versa. - CORRECT ANSWER -
True
If two live vaccines are given simultaneously sly on the same day, then you must wait _____ minimum
interval. - CORRECT ANSWER - 28-day minimum interval so that each vaccine can replicate
properly.
,Live vaccines followed by blood products (contain antibodies) require ______minimum interval. -
CORRECT ANSWER - 2 weeks.
Which of the following is an example of passive immunity?
a.) Contracting measles
b.) Hep B Vaccine
c.) Skin Barrier
d.) Maternal antibodies - CORRECT ANSWER - d.) Maternal antibodies
Why is spacing and timing of vaccines important? - CORRECT ANSWER - Circulating antibodies
may interfere with immune response
How long does it take for the immune system to provide protection by producing disease-specific
antibodies and memory cells? - CORRECT ANSWER - 14 days
When does Active Immunity occur? - CORRECT ANSWER - When a patient is exposed to an
antigen that triggers the body's immune system to produce it's own disease-specific antibodies and
memory cells.
Children less than what age do not mount an adequate immune response to t-cell independent immunity? -
CORRECT ANSWER - 2 years.
Which of the following is found in vaccines to evoke an immune response? - CORRECT
ANSWER - Antigens
What does attenuated mean? - CORRECT ANSWER - weakened
LAIV4 is the abbreviation for: - CORRECT ANSWER - Live Attenuated Influenza Vaccine
RV1, RV5 is the abbreviation for: - CORRECT ANSWER - Rotavirus
, VAR is the abbreviation for: - CORRECT ANSWER - Varicella
MMR is the abbreviation for: - CORRECT ANSWER - Measles, mumps, rubella
MMRV is the abbreviation for: - CORRECT ANSWER - Measles, mumps, rubella, varicella
Can inactivated vaccines replicate? - CORRECT ANSWER - No. It does not cause disease.
What are two broad categories that vaccines are classified as? - CORRECT ANSWER - 1. Live
attenuated vaccines
2. Inactivated vaccines
Cellular Vaccines - CORRECT ANSWER - 1. Inactivated Vaccines
2. Whole viruses or bacteria
3. Known as Subunits (fractions)
4. DTP/DTaP
Toxoid Vaccines - CORRECT ANSWER - 1. Inactivated Vaccine
2. Subunit (fractions)
3. Inactive or biological toxin
4. Tetanus toxoid
Recombinant Vaccine - CORRECT ANSWER - 1. Produced by genetic engineering
2. May contain no actual virus or a modified strain of a virus
3. HepB, HPV, RZV, RIV4
What clinical factors need to be considered before administering a lie attenuated vaccine? - CORRECT
ANSWER - 1. Patients who currently are immunocompromised
2. Live attenuated vaccines administered in the previous 28 days.
