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Samenvatting Farmacologie Verpleegkundigen HBO 2026 - ADME Opioïden Insuline Antistolling APINCH Pijnladder + 30 Rekenopgaven

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COMPLETE SAMENVATTING FARMACOLOGIE VOOR VERPLEEGKUNDIGEN HBO 2026 + 30 REKENOPGAVEN DEEL 1 - THEORIE (12 hoofdstukken): • Farmacokinetiek ADME (absorptie, distributie, metabolisme CYP450, excretie, halfwaardetijd) • Farmacodynamiek (agonist/antagonist, therapeutische breedte, smal venster) • Cardiovasculaire middelen (ACE-remmers, bètablokkers, diuretica lis/thiazide/kaliumsparend, nitraten, digoxine) • Respiratoire middelen (SABA/LABA, SAMA/LAMA, ICS, inhalatietechniek) • WHO-pijnladder (paracetamol max 4g, NSAID's COX, opioïden bijwerkingen + naloxon) • Psychofarmaca (SSRI, SNRI, TCA, benzodiazepines, antipsychotica, lithium) • Anti-infectiva (penicillinen, cefalosporinen, macroliden, antibioticaresistentie) • Insulinetypen (ultrakortwerkend → langwerkend) + orale antidiabetica (metformine, SGLT2, GLP-1) • Corticosteroïden (NOOIT plots stoppen! Cushing, afbouwen) • Antistolling (VKA + INR vs. DOAC, LMWH, antidota bij bloeding) • Medicatieveiligheid (5 juistheden, APINCH, dubbele controle, interacties) DEEL 2 - 30 REKENOPGAVEN: tabletten, infuussnelheid, druppels/min, dosis/kg, verdunningen HBO: Verpleegkunde, Duale Verpleegkunde, MBO-V niveau 4

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Samenvatting Farmacologie voor Verpleegkundi-
gen
Geneesmiddelgroepen, Werkingsmechanismen en Berekenin-
gen
Complete Samenvatting + 30 Rekenopgaven


Versie: 2026
Geschikt voor: HBO Verpleegkunde, Duale Verpleegkunde, MBO Ver-
pleegkunde niveau 4
Inhoud: Alle kernthema’s farmacologie + 30 rekenopgaven + begrippenlijst


� Heeft deze samenvatting je geholpen bij je tentamen? Laat dan een
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Inhoudsopgave
DEEL 1 – THEORIE 1. Inleiding Farmacologie 2. Farmacokinetiek (ADME)
3. Farmacodynamiek 4. Cardiovasculaire Geneesmiddelen 5. Respiratoire Ge-
neesmiddelen 6. Analgetica (Pijnstilling) 7. Psychofarmaca 8. Anti-infectiva
9. Endocriene Farmacologie 10. Maag-Darm Farmacologie 11. Antistolling en
Trombose 12. Medicatieveiligheid
DEEL 2 – 30 REKENOPGAVEN




DEEL 1: THEORIE


Hoofdstuk 1: Inleiding Farmacologie
1.1 Kernbegrippen

Begrip Definitie
Farmacologie Studie van geneesmiddelen: werking,
bijwerkingen, interacties
Farmaceutisch Hoe het geneesmiddel is gemaakt (tablet,
infuus, zalf)



1

, Begrip Definitie
Farmacokinetiek Wat het lichaam doet met het geneesmiddel
(ADME)
Farmacodynamiek Wat het geneesmiddel doet met het lichaam
Generiek Werkzame stof (bijv. paracetamol)
Specialité Merknaam (bijv. Panadol)


1.2 Toedieningswegen

Route Voorbeeld Voordeel
Oraal (p.o.) Tablet, capsule, drank Gemakkelijk, goedkoop
Sublinguaal Nitroglycerinetablet Snel, omzeilt first-pass
Rectaal Zetpil Bij braken, kinderen
Intraveneus Infuus, injectie Snelste werking, 100%
(i.v.) beschikbaar
Intramusculair Injectie in spier Depot-effect mogelijk
(i.m.)
Subcutaan Insuline, LMWH Zelftoediening
(s.c.)
Inhalatie Puffer, vernevelaar Lokaal in longen
Transdermaal Pleister (fentanyl) Continue afgifte
Topicaal Zalf, crème, druppels Lokaal effect




Hoofdstuk 2: Farmacokinetiek (ADME)
2.1 De Vier Fasen
A – Absorptie → D – Distributie → M – Metabolisme → E – Excretie
(opname) (verspreiding) (omzetting) (uitscheiding)

2.2 Absorptie

Factor Invloed
Toedieningsweg i.v. = 100% biologische beschikbaarheid
Maaginhoud Voedsel kan absorptie vertragen of
verminderen
pH maag Beïnvloedt oplosbaarheid
First-pass effect Lever breekt deel af vóór systemische
circulatie




2

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