CLINICAL CHEMISTRY PRACTICE QUESTIONS
AND ANSWER PART 1 ,2 AND 3
, PRE-BOARD EXAMINATION IN CLINICAL CHEMISTRY (PART 1)
1. All of the following are correct match, EXCEPT:
Conversion of Conventional Unit to SI Unit:
Conventional Unit SI Unit
A Cholesterol 150 mg/dL 3.88 mmol/L
B Triglyceride 10 mg/dL 0.11 mmol/L
C Glucose 70 mg/dL 3.9 mmol/L
D BUN 8 mg/dL 0.47 mmol/L
2. A cholesterol quality control chart has the following data for the normal control:
Mean o f the data (X) = 150 mg/dL
2 Standard deviation = 4
X = 1,372 mg/dL
N = 10
Determine the coefficient of variation for this control:
A. 1.33% B. 2.67% C. 15.0 % D. 7.06%
3. The extent to which measurements agree with the true value of the quantity being measured is known as:
A. Acceptable limits B. Accuracy C. Precision D. Reliability
4. The reproducibility of test measurements is referred to as:
A. Accuracy B. Precision C. Quality control D. Reliability
5. In a Gaussian curve distribution, the 2 SD range includes the following percentage of values:
A. 31.6% B. 68.3% C. 95.5% D. 99.7%
6. Which Westgard rule detects random error?
A. 13s B. 41s C. 22s D. 100
7. The component of a spectrophotometer that is responsible for detecting transmitted light and converting light energy
to electrical energy is the:
A. Detector B. Analytical cell C. Monochromator D. Readout device
8. The process by which fluorescence of an analyte is reduced due to the excited molecule losing some of its energy by
interacting with other substances in a solution is known as:
A. Ionization B. Quenching C. Phosphorescence D. Self-absorption
9. In flow cytometry, the side scatter is related to the:
A. DNA content of the cell C. Size of the cell
B. Granularity of the cell D. Number of cells in G0 and G1
10. Which of the following approaches of automated analyzers uses a rotor to mix reagents?
A. Centrifugal analysis C. Discrete analysis
B. Continuous flow D. Dry chemistry slide analysis
11. Which of the following chemistry analyzers uses “slides” to contain the entire reagent system?
A. Vitros© analyzers C. Paramax© analyzers
B. ACA© analyzers D. None of the above
12. Ceruloplasmin and haptoglobin migrate electrophoretically as:
A. Alpha1 globulins B. Alpha2 globulins C. Beta globulins D. Gamma globulins
13. In cirrhosis, a predominant characteristic observed in electrophoretic serum pattern is a(an):
A. Increase in alpha2 globulin fraction C. Monoclonal band in gamma globulin region
B. Bridging effect between beta and gamma globulin fraction D. Polyclonal band in gamma globulin region
14. A congenital disorder characterized by a split in the albumin band when serum is subjected to electrophoresis is
known as:
A. Analbuminemia C. Bisalbuminemia
B. Anodic albuminemia D. Prealbuminemia
15. Which enzymes are generally quantitated to help diagnose acute pancreatitis?
A. ALT and CK C. Amylase and lipase
B. ALT and LD D. ALP and cholinesterase
16. Serum levels of total CK are elevated after an acute myocardial infarction and in which of the following conditions?
A. Diabetes mellitus C. Duchenne type muscular dystrophy
B. Chronic renal failure D. Early pregnancy
17. The isoenzymes LD-4 and LD-5 are elevated in:
A. Pulmonary embolism C. Renal disease
B. Liver disease D. Myocardial infarction
18. Which of the following liver enzymes is the best to use to evaluate liver function?
A. AST B. GGT C. ALT D. LD
19. In an adult, a normal GGT level with an elevated serum ALP level may be suggestive of:
A. Bone disease C. Liver disease
B. Heart disease D. Skeletal muscle disease
20. A decreased LDH/HBD ratio is significant for:
A. Myocardial infraction C. Both of these
B. Liver disease D. None of these
21. Isoenzyme of ALP that is most heat stable:
A. Placental ALP C. Intestinal ALP
B. Bone ALP D. Liver ALP
22. Which of the following enzymes exhibit a decreased serum level in liver disease?
A. Alanine aminotransferase D. Cholinesterase
B. Gamma glutamyltransferase E. All of the above
C. Lactate dehydrogenase
AND ANSWER PART 1 ,2 AND 3
, PRE-BOARD EXAMINATION IN CLINICAL CHEMISTRY (PART 1)
1. All of the following are correct match, EXCEPT:
Conversion of Conventional Unit to SI Unit:
Conventional Unit SI Unit
A Cholesterol 150 mg/dL 3.88 mmol/L
B Triglyceride 10 mg/dL 0.11 mmol/L
C Glucose 70 mg/dL 3.9 mmol/L
D BUN 8 mg/dL 0.47 mmol/L
2. A cholesterol quality control chart has the following data for the normal control:
Mean o f the data (X) = 150 mg/dL
2 Standard deviation = 4
X = 1,372 mg/dL
N = 10
Determine the coefficient of variation for this control:
A. 1.33% B. 2.67% C. 15.0 % D. 7.06%
3. The extent to which measurements agree with the true value of the quantity being measured is known as:
A. Acceptable limits B. Accuracy C. Precision D. Reliability
4. The reproducibility of test measurements is referred to as:
A. Accuracy B. Precision C. Quality control D. Reliability
5. In a Gaussian curve distribution, the 2 SD range includes the following percentage of values:
A. 31.6% B. 68.3% C. 95.5% D. 99.7%
6. Which Westgard rule detects random error?
A. 13s B. 41s C. 22s D. 100
7. The component of a spectrophotometer that is responsible for detecting transmitted light and converting light energy
to electrical energy is the:
A. Detector B. Analytical cell C. Monochromator D. Readout device
8. The process by which fluorescence of an analyte is reduced due to the excited molecule losing some of its energy by
interacting with other substances in a solution is known as:
A. Ionization B. Quenching C. Phosphorescence D. Self-absorption
9. In flow cytometry, the side scatter is related to the:
A. DNA content of the cell C. Size of the cell
B. Granularity of the cell D. Number of cells in G0 and G1
10. Which of the following approaches of automated analyzers uses a rotor to mix reagents?
A. Centrifugal analysis C. Discrete analysis
B. Continuous flow D. Dry chemistry slide analysis
11. Which of the following chemistry analyzers uses “slides” to contain the entire reagent system?
A. Vitros© analyzers C. Paramax© analyzers
B. ACA© analyzers D. None of the above
12. Ceruloplasmin and haptoglobin migrate electrophoretically as:
A. Alpha1 globulins B. Alpha2 globulins C. Beta globulins D. Gamma globulins
13. In cirrhosis, a predominant characteristic observed in electrophoretic serum pattern is a(an):
A. Increase in alpha2 globulin fraction C. Monoclonal band in gamma globulin region
B. Bridging effect between beta and gamma globulin fraction D. Polyclonal band in gamma globulin region
14. A congenital disorder characterized by a split in the albumin band when serum is subjected to electrophoresis is
known as:
A. Analbuminemia C. Bisalbuminemia
B. Anodic albuminemia D. Prealbuminemia
15. Which enzymes are generally quantitated to help diagnose acute pancreatitis?
A. ALT and CK C. Amylase and lipase
B. ALT and LD D. ALP and cholinesterase
16. Serum levels of total CK are elevated after an acute myocardial infarction and in which of the following conditions?
A. Diabetes mellitus C. Duchenne type muscular dystrophy
B. Chronic renal failure D. Early pregnancy
17. The isoenzymes LD-4 and LD-5 are elevated in:
A. Pulmonary embolism C. Renal disease
B. Liver disease D. Myocardial infarction
18. Which of the following liver enzymes is the best to use to evaluate liver function?
A. AST B. GGT C. ALT D. LD
19. In an adult, a normal GGT level with an elevated serum ALP level may be suggestive of:
A. Bone disease C. Liver disease
B. Heart disease D. Skeletal muscle disease
20. A decreased LDH/HBD ratio is significant for:
A. Myocardial infraction C. Both of these
B. Liver disease D. None of these
21. Isoenzyme of ALP that is most heat stable:
A. Placental ALP C. Intestinal ALP
B. Bone ALP D. Liver ALP
22. Which of the following enzymes exhibit a decreased serum level in liver disease?
A. Alanine aminotransferase D. Cholinesterase
B. Gamma glutamyltransferase E. All of the above
C. Lactate dehydrogenase
