NR565/NR 565 Pharmacology Final Exam
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questions and correct verified answers
(detailed answers) already graded A+
Hyperthyroid Treatment
thionamide drugs—methimazole and propylthiouracil
(PTU)—suppress synthesis of thyroid hormones.
Methimazole Therapeutic Goal
(1) reduction of thyroid hormone production in
Graves' disease, (2) control of hyperthyroidism until
the effects of radiation on the thyroid become
manifest, (3) suppression of thyroid hormone
production before subtotal thyroidectomy, (4)
treatment of thyrotoxic crisis.
,Monitoring needs and intervals for Methimazole
Check CBC with differential if signs or symptoms of
infection. Check LFTs if signs or symptoms of liver
dysfunction.
High Risk Patients for Methimazole
Should be avoided in the first trimester of pregnancy.
Methimazole Toxicity
Agranulocytosis is the most dangerous toxicity.
PTU High Risk Warning
Carries a risk for liver toxicity. Although rare, the FDA
recommends against using as a first-line treatment
due to potential for hepatic toxicity.
,Effects of maternal hypothyroidism on offspring and
appropriate patient teaching related to need for
treatment.
Can cause delay in mental development and
derangement of growth. In the absence of thyroid
hormones, the child develops a large and protruding
tongue, potbelly, and dwarfish stature. Development
of the nervous system, bones, teeth, and muscles is
impaired.
Congenital Hypothyroidism Treatment
requires replacement therapy with thyroid hormones.
If treatment is initiated within a few days of birth,
physical and mental development will be normal.
replacement therapy should continue for 3 years,
after which it should be stopped for 4 weeks to
determine whether thyroid deficiency is permanent
or transient.
, Patient Teaching for Methimazole
Tell your healthcare providers that you are taking this
drug.
Check blood work as directed.
Taking this drug may cause harm to the unborn baby
if you are pregnant, especially in the first trimester.
If you are pregnant or become pregnant while taking
this drug, call your healthcare provider right away.
Tell your healthcare provider if you are breast-
feeding to discuss risks to the baby.
Have your baby's thyroid checked if you are using
this drug and breast-feeding.
Agranulocytosis is the most dangerous toxicity risk
for this medication but is very rare. Sore throat and
fever should be reported immediately.
Questions with Newest complete
questions and correct verified answers
(detailed answers) already graded A+
Hyperthyroid Treatment
thionamide drugs—methimazole and propylthiouracil
(PTU)—suppress synthesis of thyroid hormones.
Methimazole Therapeutic Goal
(1) reduction of thyroid hormone production in
Graves' disease, (2) control of hyperthyroidism until
the effects of radiation on the thyroid become
manifest, (3) suppression of thyroid hormone
production before subtotal thyroidectomy, (4)
treatment of thyrotoxic crisis.
,Monitoring needs and intervals for Methimazole
Check CBC with differential if signs or symptoms of
infection. Check LFTs if signs or symptoms of liver
dysfunction.
High Risk Patients for Methimazole
Should be avoided in the first trimester of pregnancy.
Methimazole Toxicity
Agranulocytosis is the most dangerous toxicity.
PTU High Risk Warning
Carries a risk for liver toxicity. Although rare, the FDA
recommends against using as a first-line treatment
due to potential for hepatic toxicity.
,Effects of maternal hypothyroidism on offspring and
appropriate patient teaching related to need for
treatment.
Can cause delay in mental development and
derangement of growth. In the absence of thyroid
hormones, the child develops a large and protruding
tongue, potbelly, and dwarfish stature. Development
of the nervous system, bones, teeth, and muscles is
impaired.
Congenital Hypothyroidism Treatment
requires replacement therapy with thyroid hormones.
If treatment is initiated within a few days of birth,
physical and mental development will be normal.
replacement therapy should continue for 3 years,
after which it should be stopped for 4 weeks to
determine whether thyroid deficiency is permanent
or transient.
, Patient Teaching for Methimazole
Tell your healthcare providers that you are taking this
drug.
Check blood work as directed.
Taking this drug may cause harm to the unborn baby
if you are pregnant, especially in the first trimester.
If you are pregnant or become pregnant while taking
this drug, call your healthcare provider right away.
Tell your healthcare provider if you are breast-
feeding to discuss risks to the baby.
Have your baby's thyroid checked if you are using
this drug and breast-feeding.
Agranulocytosis is the most dangerous toxicity risk
for this medication but is very rare. Sore throat and
fever should be reported immediately.
