600+ QUESTIONS BANK
high-yield questions designed to mirror the
latest ANCC blueprint (2025)
Pass on the first attempt.
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Multiple choice questions (MCQs) with single best answer.
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,**1. A 50-year-old woman presents to the clinic for follow-up on her
type 2 diabetes mellitus. She is currently taking metformin
(Glumetza) at her maximum tolerated dose, and her HbA1C at the
current appointment is 8.6%. The patient is not open to insulin and
wants to try alternative medications to reduce her HbA1C. Which of
the following medications will directly stimulate the release of insulin
from pancreatic beta cells, thereby lowering blood glucose
concentrations?**
A. Acarbose (Precose)
B. Dulaglutide (Trulicity)
C. Empagliflozin (Jardiance)
D. Glipizide (Glucotrol)
**Correct Answer:** D. Glipizide (Glucotrol)
**Rationale:**
Glipizide is a sulfonylurea that acts by directly stimulating pancreatic
beta cells to release insulin, thus reducing blood glucose. Acarbose
,inhibits intestinal alpha-glucosidase, delaying carbohydrate absorption
but does not increase insulin secretion. Dulaglutide is a GLP-1 receptor
agonist which indirectly enhances glucose-dependent insulin secretion
but does not directly stimulate beta cells independent of glucose.
Empagliflozin reduces glucose by increasing renal excretion without
affecting insulin release. For a patient unwilling to use insulin, a
sulfonylurea like glipizide is a reasonable next step to target insulin
secretion.
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**2. An 18-year-old patient presents with unilateral ear pain for 2
days. On otoscopic exam, the tympanic membrane is bulging and
appears inflamed. The posterior landmarks are obscured, and the
light reflex is distorted. Which of the following is the most likely
diagnosis?**
A. Mastoiditis
B. Otitis externa
C. Otitis media
, D. Presbycusis
**Correct Answer:** C. Otitis media
**Rationale:**
Acute otitis media presents with tympanic membrane bulging,
erythema, and loss of landmarks. Pain and inflammation are typical
signs. Otitis externa affects the external ear canal and is often
associated with tenderness of the auricle and canal edema. Mastoiditis
is a complication of otitis media with postauricular pain and swelling,
which is not described here. Presbycusis is age-related sensorineural
hearing loss and does not present acutely with ear pain or visible TM
changes.
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**3. A 7-year-old boy with a past medical history of atopic dermatitis
presents to the clinic with his father for concern about an allergic
reaction. He states that 2 hours ago, after eating lunch, he developed
an itchy throat and eye swelling. He reports no wheezing or