Define polyuria
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excessive urination
SIADH effect on water reabsorption in renal tubules
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increased permeability of renal tubules to water which increases water
reabsorption by the kidneys
, Why do some type 2 diabetics with poor glycemic control eventually require insulin
to treat their hyperglycemia?
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some people have complications associated with uncontrolled
hyperglycemia and chronic insulinemia that can cause beta cell injury or
beta cell destruction which results in decreased and eventually absent
insulin secretion which causes them to need to be treated like a type 1
diabetic and they require insulin to treat their diabetes.
Pathophysiological basis for Glycosuria in type 1 DM.
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under normal circumstances renal tubules reabsorb 100% of filtered
glucose. with hyperglycemia the renal tubules reach their transport
maximum (Tmax) for glucose reabsorption. Tmax corresponds to about 180
mg/dL glucose in the blood. therefor excess glucose remains in the urine
filtrate and attracts water into the tubules leading to diuresis and
dehydration
Pathophysiological basis for Polyuria in type 1 DM.
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very high concentrations of glucose in the blood and in the bowman's or
glomerular capsule catches the fluid that is going to escape and go into
the renal tubules and whatever stays within the tubule is urinated. because
glucose is so high, glucose gets left in the renal tubule and water is pulled
from tissues surrounding it and end up in the renal tubule with the glucose
Give this one a try later!
excessive urination
SIADH effect on water reabsorption in renal tubules
Give this one a try later!
increased permeability of renal tubules to water which increases water
reabsorption by the kidneys
, Why do some type 2 diabetics with poor glycemic control eventually require insulin
to treat their hyperglycemia?
Give this one a try later!
some people have complications associated with uncontrolled
hyperglycemia and chronic insulinemia that can cause beta cell injury or
beta cell destruction which results in decreased and eventually absent
insulin secretion which causes them to need to be treated like a type 1
diabetic and they require insulin to treat their diabetes.
Pathophysiological basis for Glycosuria in type 1 DM.
Give this one a try later!
under normal circumstances renal tubules reabsorb 100% of filtered
glucose. with hyperglycemia the renal tubules reach their transport
maximum (Tmax) for glucose reabsorption. Tmax corresponds to about 180
mg/dL glucose in the blood. therefor excess glucose remains in the urine
filtrate and attracts water into the tubules leading to diuresis and
dehydration
Pathophysiological basis for Polyuria in type 1 DM.
Give this one a try later!
very high concentrations of glucose in the blood and in the bowman's or
glomerular capsule catches the fluid that is going to escape and go into
the renal tubules and whatever stays within the tubule is urinated. because
glucose is so high, glucose gets left in the renal tubule and water is pulled
from tissues surrounding it and end up in the renal tubule with the glucose
