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N5313 CHAPTER 45: ALTERATIONS OF
MUSCULOSKELETAL FUNCTION 2026
ACTUAL QUESTIONS WITH VERIFIED
ANSWERS.
Which statement is false concerning giant cell tumors?
a.
Giant cell tumors are an overexpression of genes including
osteoprotegerin ligand (OPGL).
b.
The tumors are malignant, solitary, and irregularly shaped.
c.
Giant cell tumors are typically located in the epiphysis in
the femur, tibia, radius, and humerus.
d.
They are slow-growing tumors that extend over the
articular cartilage.
B
Which is a characteristic of inflammatory joint disease?
a.
Unilateral joint involvement
b.
Normal joint synovial fluid
c.
Absence of synovial membrane inflammation
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d.
Systemic symptoms of inflammation
D
What is a primary defect in osteoarthritis?
a.
Stromelysin and acid metalloproteinase break down
articular cartilage.
b.
Immunoglobulin G (IgG) destroys the synovial membrane.
c.
Synovial membranes become inflamed.
d.
Cartilage-coated osteophytes create bone spurs.
A
In osteoarthritis, what is the effect of the disruption of the
pumping action of proteoglycans?
a.
Pump malfunction stimulates the induction of nitric oxide
synthase and nitric oxide, which degrades the cartilage.
b.
Cartilage is damaged by proteolytic enzymes because they
cannot be pumped out of the joint.
c.
Cartilage becomes dry, brittle, and wears away because
fluid cannot be pumped into the cartilage.
d.
Cartilage takes in too much fluid and is unable to
withstand the stresses of weight bearing.
D
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Which joint disease is characterized by joint stiffness on
movement and joint pain of weight-bearing joints that is
usually relieved by rest?
a.
Gouty arthritis
c.
Osteoarthritis
b.
Rheumatoid arthritis
d.
Suppurative arthritis
C
Which medical diagnosis is described as a chronic
inflammatory joint disease characterized by stiffening and
fusion of the spine and sacroiliac joints?
a.
Ankylosing spondylitis
c.
Paget disease
b.
Rheumatoid arthritis
d.
Fibromyalgia
A
What is the primary pathologic alteration resulting from
ankylosing spondylitis (AS)?
a.
Inflammation of the sacroiliac joint
b.
Inflammation of the long bones
c.
N5313 CHAPTER 45: ALTERATIONS OF
MUSCULOSKELETAL FUNCTION 2026
ACTUAL QUESTIONS WITH VERIFIED
ANSWERS.
Which statement is false concerning giant cell tumors?
a.
Giant cell tumors are an overexpression of genes including
osteoprotegerin ligand (OPGL).
b.
The tumors are malignant, solitary, and irregularly shaped.
c.
Giant cell tumors are typically located in the epiphysis in
the femur, tibia, radius, and humerus.
d.
They are slow-growing tumors that extend over the
articular cartilage.
B
Which is a characteristic of inflammatory joint disease?
a.
Unilateral joint involvement
b.
Normal joint synovial fluid
c.
Absence of synovial membrane inflammation
, Page | 2
d.
Systemic symptoms of inflammation
D
What is a primary defect in osteoarthritis?
a.
Stromelysin and acid metalloproteinase break down
articular cartilage.
b.
Immunoglobulin G (IgG) destroys the synovial membrane.
c.
Synovial membranes become inflamed.
d.
Cartilage-coated osteophytes create bone spurs.
A
In osteoarthritis, what is the effect of the disruption of the
pumping action of proteoglycans?
a.
Pump malfunction stimulates the induction of nitric oxide
synthase and nitric oxide, which degrades the cartilage.
b.
Cartilage is damaged by proteolytic enzymes because they
cannot be pumped out of the joint.
c.
Cartilage becomes dry, brittle, and wears away because
fluid cannot be pumped into the cartilage.
d.
Cartilage takes in too much fluid and is unable to
withstand the stresses of weight bearing.
D
, Page | 3
Which joint disease is characterized by joint stiffness on
movement and joint pain of weight-bearing joints that is
usually relieved by rest?
a.
Gouty arthritis
c.
Osteoarthritis
b.
Rheumatoid arthritis
d.
Suppurative arthritis
C
Which medical diagnosis is described as a chronic
inflammatory joint disease characterized by stiffening and
fusion of the spine and sacroiliac joints?
a.
Ankylosing spondylitis
c.
Paget disease
b.
Rheumatoid arthritis
d.
Fibromyalgia
A
What is the primary pathologic alteration resulting from
ankylosing spondylitis (AS)?
a.
Inflammation of the sacroiliac joint
b.
Inflammation of the long bones
c.
