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NR565 / NR 565 Advanced Pharmacology
Care of the Fundamentals Midterm
Exam | Chamberlain University
(2026/2027) | Verified Questions &
Answers with Rationales
Exam Structure:
Subject: Advanced Pharmacology (NR565) – Midterm Exam
Source: NR565 / NR 565 Advanced Pharmacology Care of the Fundamentals –
Midterm Exam (Chamberlain)
Format: Multiple Choice & Open-Ended Q&A
1. What are two functions of naloxone when a patient is on
buprenorphine?
A. Prevention of toxicity
B. Stop constipation caused by buprenorphine
C. Cannot readily reverse toxicity already occurring
D. Both A and C
Correct Answer: D. Both A and C
Rationale:
1. Naloxone is added to buprenorphine (Suboxone) to deter intravenous
abuse.
2. When taken as prescribed sublingually, naloxone has minimal effect.
3. If injected, naloxone precipitates withdrawal (prevents toxicity – A).
4. However, naloxone cannot readily reverse the effects of buprenorphine due
to buprenorphine's high receptor affinity (C).
2. Why must an NP be cautious when prescribing medications to the
elderly population?
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A. Due to their diagnosis of dementia
B. They are high risk for polypharmacy
C. The elderly population metabolizes medication faster
D. Prescribe as usual. No difference in elderly patients
Correct Answer: B. They are high risk for polypharmacy.
Rationale:
1. Polypharmacy (≥5 medications) increases risk of drug interactions and
adverse effects.
2. Elderly patients often see multiple prescribers, leading to duplication.
*3. Age-related pharmacokinetic changes (reduced renal/hepatic function)
increase risk.*
4. Beers Criteria identifies potentially inappropriate medications in older
adults.
3. There are several points of education that should be given to a
patient taking acetaminophen. Which statement made by the patient
is incorrect?
A. “If I take one dose, I should wait at least four hours to take another.”
B. “There is no limit to how many tablets I can take each day.”
C. “I should not take Tylenol if I have liver disease or chronically drink
alcohol.”
D. “I can take 325-650mg for mild pain, and 500-1000mg for moderate
pain.”
Correct Answer: B. “There is no limit to how many tablets I can take each
day.”
Rationale:
1. Maximum daily dose for acetaminophen is 4 g (3 g for older adults or liver
disease).
2. Exceeding the limit causes hepatotoxicity.
3. Patients must count all sources of acetaminophen (combination products).
4. Statement B is false and dangerous.
4. What is the point of a prescription drug monitoring program
(PDMP)?
A. Help identify patients who may be at risk for overdose
B. Make prescribing faster for providers
C. Educate patients about overdose
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D. Provide correct dosing and pricing information for providers
Correct Answer: A. Help identify patients who may be at risk for overdose.
Rationale:
1. PDMP tracks controlled substance prescriptions across providers and
pharmacies.
*2. Identifies “doctor shopping,” early refills, and high-risk combinations.*
3. Reduces opioid overdose risk by informing prescribing decisions.
4. Most states mandate PDMP use before prescribing controlled substances.
5. The purpose of black box warnings is to make providers aware of:
A. Ways to reduce and prevent harm, such as pregnant women avoiding
teratogenic drugs
B. Potential common side effects, such as nausea, vomiting, or upset
stomach
C. Potential severe side effects, such as fetal harm, suicidality, or near-fatal
dysrhythmias
D. Both A and C
Correct Answer: D. Both A and C.
Rationale:
1. Black box warnings (BBW) are the FDA's strongest safety warning.
*2. They highlight serious or life-threatening risks (C).*
3. They also provide guidance on risk mitigation (e.g., pregnancy prevention
programs – A).
4. Common side effects (B) are not included in BBW.
6. Patients with renal and hepatic insufficiency can experience all of
the following effects from medications EXCEPT:
A. Greater peak effects
B. Longer duration of action
C. Increased risk for respiratory depression
D. Increased dosages of medications
E. Increased risk of overdose
Correct Answer: D. Increased dosages of medications.
Rationale:
*1. Renal/hepatic insufficiency decreases drug clearance.*
*2. This leads to higher peak levels (A), longer duration (B), and increased
toxicity/overdose (C, E).*
NR565 / NR 565 Advanced Pharmacology
Care of the Fundamentals Midterm
Exam | Chamberlain University
(2026/2027) | Verified Questions &
Answers with Rationales
Exam Structure:
Subject: Advanced Pharmacology (NR565) – Midterm Exam
Source: NR565 / NR 565 Advanced Pharmacology Care of the Fundamentals –
Midterm Exam (Chamberlain)
Format: Multiple Choice & Open-Ended Q&A
1. What are two functions of naloxone when a patient is on
buprenorphine?
A. Prevention of toxicity
B. Stop constipation caused by buprenorphine
C. Cannot readily reverse toxicity already occurring
D. Both A and C
Correct Answer: D. Both A and C
Rationale:
1. Naloxone is added to buprenorphine (Suboxone) to deter intravenous
abuse.
2. When taken as prescribed sublingually, naloxone has minimal effect.
3. If injected, naloxone precipitates withdrawal (prevents toxicity – A).
4. However, naloxone cannot readily reverse the effects of buprenorphine due
to buprenorphine's high receptor affinity (C).
2. Why must an NP be cautious when prescribing medications to the
elderly population?
, 2|Page
A. Due to their diagnosis of dementia
B. They are high risk for polypharmacy
C. The elderly population metabolizes medication faster
D. Prescribe as usual. No difference in elderly patients
Correct Answer: B. They are high risk for polypharmacy.
Rationale:
1. Polypharmacy (≥5 medications) increases risk of drug interactions and
adverse effects.
2. Elderly patients often see multiple prescribers, leading to duplication.
*3. Age-related pharmacokinetic changes (reduced renal/hepatic function)
increase risk.*
4. Beers Criteria identifies potentially inappropriate medications in older
adults.
3. There are several points of education that should be given to a
patient taking acetaminophen. Which statement made by the patient
is incorrect?
A. “If I take one dose, I should wait at least four hours to take another.”
B. “There is no limit to how many tablets I can take each day.”
C. “I should not take Tylenol if I have liver disease or chronically drink
alcohol.”
D. “I can take 325-650mg for mild pain, and 500-1000mg for moderate
pain.”
Correct Answer: B. “There is no limit to how many tablets I can take each
day.”
Rationale:
1. Maximum daily dose for acetaminophen is 4 g (3 g for older adults or liver
disease).
2. Exceeding the limit causes hepatotoxicity.
3. Patients must count all sources of acetaminophen (combination products).
4. Statement B is false and dangerous.
4. What is the point of a prescription drug monitoring program
(PDMP)?
A. Help identify patients who may be at risk for overdose
B. Make prescribing faster for providers
C. Educate patients about overdose
, 3|Page
D. Provide correct dosing and pricing information for providers
Correct Answer: A. Help identify patients who may be at risk for overdose.
Rationale:
1. PDMP tracks controlled substance prescriptions across providers and
pharmacies.
*2. Identifies “doctor shopping,” early refills, and high-risk combinations.*
3. Reduces opioid overdose risk by informing prescribing decisions.
4. Most states mandate PDMP use before prescribing controlled substances.
5. The purpose of black box warnings is to make providers aware of:
A. Ways to reduce and prevent harm, such as pregnant women avoiding
teratogenic drugs
B. Potential common side effects, such as nausea, vomiting, or upset
stomach
C. Potential severe side effects, such as fetal harm, suicidality, or near-fatal
dysrhythmias
D. Both A and C
Correct Answer: D. Both A and C.
Rationale:
1. Black box warnings (BBW) are the FDA's strongest safety warning.
*2. They highlight serious or life-threatening risks (C).*
3. They also provide guidance on risk mitigation (e.g., pregnancy prevention
programs – A).
4. Common side effects (B) are not included in BBW.
6. Patients with renal and hepatic insufficiency can experience all of
the following effects from medications EXCEPT:
A. Greater peak effects
B. Longer duration of action
C. Increased risk for respiratory depression
D. Increased dosages of medications
E. Increased risk of overdose
Correct Answer: D. Increased dosages of medications.
Rationale:
*1. Renal/hepatic insufficiency decreases drug clearance.*
*2. This leads to higher peak levels (A), longer duration (B), and increased
toxicity/overdose (C, E).*
