Diagnostic Reasoning | Already Graded A | Walden University
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Section 1: Foundations & Diagnostic Reasoning
15 questions covering DSM-5-TR structure, cultural formulation, neurobiology, diagnostic
reasoning, cognitive biases, MSE, and screening tools
Q1: A 34-year-old patient from a rural Mexican background describes experiencing
"ataque de nervios" during stressful family gatherings—shouting, crying, trembling, and
heat in the chest that resolves within minutes. There are no persistent psychotic
symptoms between episodes. Which cultural formulation approach is most
appropriate?
A. Diagnose brief psychotic disorder and prescribe antipsychotics
B. Recognize as a cultural idiom of distress and explore meaning with the Cultural
Formulation Interview
C. Diagnose panic disorder and start SSRIs immediately
,D. Label as factitious disorder due to attention-seeking behavior
Correct Answer: B
Rationale: For the NRNP6635 final exam (Graded A level), remember that ataque de
nervios is a recognized cultural idiom of distress, not a psychotic disorder or panic
disorder, though it may co-occur with DSM diagnoses. The CFI helps distinguish cultural
expressions from pathology without pathologizing normative experiences.
Q2: During a mental status examination, a patient demonstrates loosening of
associations, tangentiality, and clang associations. Which neurotransmitter system is
most implicated in this thought process disturbance?
A. Dopaminergic hyperactivity in mesolimbic pathways
B. Serotonergic deficiency in raphe nuclei
C. GABAergic dysfunction in hippocampal circuits
D. Cholinergic excess in basal forebrain
Correct Answer: A
Rationale: Disorganized thought processes—loosening of associations, tangentiality,
clang associations—are hallmark positive symptoms of psychosis driven by
,dopaminergic hyperactivity in mesolimbic pathways. That's why antipsychotics, which
block D2 receptors, target these symptoms specifically.
Q3: A PMHNP is evaluating a 28-year-old with first-episode psychosis. Which medical
workup is essential before establishing a primary psychiatric diagnosis?
A. CBC, CMP, TSH, B12, folate, RPR/VDRL, HIV, UA with toxicology, and head CT or MRI
B. CBC and TSH only; psychiatric diagnosis is primarily clinical
C. Lumbar puncture and EEG for all first-episode psychosis patients
D. Brain MRI with contrast and PET scan for metabolic activity
Correct Answer: A
Rationale: When ruling out medical causes in first-episode psychosis, always check the
standard battery: CBC, CMP, TSH, B12, folate, syphilis serology, HIV, urinalysis with
toxicology, and neuroimaging. This rules out organic causes like thyroid dysfunction,
B12 deficiency, neurosyphilis, substance-induced psychosis, and structural lesions. LP
and EEG (C) are indicated only with specific neurologic signs.
, Q4: A patient presents with depressed mood, fatigue, and difficulty concentrating. The
PMHNP anchors on the depression diagnosis and stops exploring after confirming five
symptoms. Which cognitive bias is demonstrated, and what is the debiasing strategy?
A. Availability bias; consider alternative diagnoses that are easily recalled
B. Anchoring bias with premature closure; force consideration of bipolar disorder,
thyroid dysfunction, and substance use
C. Confirmation bias; seek disconfirming evidence actively
D. Diagnosis momentum; resist adopting the previous provider's diagnosis
Correct Answer: B
Rationale: Anchoring is latching onto an initial impression and failing to
adjust—premature closure is stopping the diagnostic process too soon. The debiasing
strategy is deliberately forcing consideration of alternatives: could this be bipolar
depression? Hypothyroidism? Substance-induced? Always ask about manic symptoms,
check TSH, and screen for substances before locking in MDD.
Q5: A patient scores 14 on the PHQ-9. Which interpretation and next step is correct?
A. Mild depression; monitor and reassess in 2 weeks