NURS 5357 LATEST
NEUROBIOLOGY EXAM
2
Arnold is a 28-year-old man with moderate depression who achieves
remission after 16 weeks on a therapeutic dose of a monoaminergic
antidepressant.
According to the neurotrophic hypothesis of depression, which of the
following is most likely true of his BDNF expression before and after
his successful treatment? - ANSWERS-BDNF expression was
abnormally low while he was depressed, and increased during
monoaminergic antidepressant treatment
The loss of growth factors, which may lead to neuroprogression, may be
caused by which of the following environmental factors? - ANSWERS-
All of the other answers
A 21-year-old female has been suffering from severe depression for the
last 3 years. She has had partial response with her current treatment;
however, she has residual complaints of physical fatigue, lack of energy,
and difficulty concentrating.
What pharmacological strategies may be most likely to target these
residual symptoms? - ANSWERS-Boost norepinephrine and/or
dopamine
END OF
PAGE 1
, NURS 5357 LATEST
NEUROBIOLOGY EXAM
2
All of the following are true about the monoamine hypothesis except? -
ANSWERS-It explains the delay in response seen with depression
treatments
Postmortem studies in depressed patients have found all of the following
except? - ANSWERS-Reduced neurons in the hypothalamus
Antidepressants may decrease depressive symptoms and improve
neuronal survival through which of the following effects? - ANSWERS-
Decrease glucocorticoids and increase BDNF.
Goals for effective treatment of depression include all of the following
except? - ANSWERS-Awaken the prefrontal cortex
Which of the following interventions has not been shown to increase
BDNF in animal models? - ANSWERS-Cognitive behavioral therapy
Possible culprits in the etiology of depression include all of the
following except? - ANSWERS-Insufficient limbic activity
END OF
PAGE 2
NEUROBIOLOGY EXAM
2
Arnold is a 28-year-old man with moderate depression who achieves
remission after 16 weeks on a therapeutic dose of a monoaminergic
antidepressant.
According to the neurotrophic hypothesis of depression, which of the
following is most likely true of his BDNF expression before and after
his successful treatment? - ANSWERS-BDNF expression was
abnormally low while he was depressed, and increased during
monoaminergic antidepressant treatment
The loss of growth factors, which may lead to neuroprogression, may be
caused by which of the following environmental factors? - ANSWERS-
All of the other answers
A 21-year-old female has been suffering from severe depression for the
last 3 years. She has had partial response with her current treatment;
however, she has residual complaints of physical fatigue, lack of energy,
and difficulty concentrating.
What pharmacological strategies may be most likely to target these
residual symptoms? - ANSWERS-Boost norepinephrine and/or
dopamine
END OF
PAGE 1
, NURS 5357 LATEST
NEUROBIOLOGY EXAM
2
All of the following are true about the monoamine hypothesis except? -
ANSWERS-It explains the delay in response seen with depression
treatments
Postmortem studies in depressed patients have found all of the following
except? - ANSWERS-Reduced neurons in the hypothalamus
Antidepressants may decrease depressive symptoms and improve
neuronal survival through which of the following effects? - ANSWERS-
Decrease glucocorticoids and increase BDNF.
Goals for effective treatment of depression include all of the following
except? - ANSWERS-Awaken the prefrontal cortex
Which of the following interventions has not been shown to increase
BDNF in animal models? - ANSWERS-Cognitive behavioral therapy
Possible culprits in the etiology of depression include all of the
following except? - ANSWERS-Insufficient limbic activity
END OF
PAGE 2
