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NUR 6121 Exam 1 Study Guide: Latest Advanced Pathophysiology Questions & Answers (Verified Solutions)

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Are you preparing for NUR 6121 Exam 1 and feeling overwhelmed by the complexity of cellular biology, inflammation, and genetic disorders? This comprehensive study resource is meticulously designed to help you conquer the first milestone of your Advanced Pathophysiology course. What’s Inside This High-Yield Guide: This document covers the exact concepts most frequently tested on NUR 6121 Exam 1, including detailed rationales and verified correct answers. Module 1: Cellular Adaptation & Injury Atrophy, Hypertrophy, Hyperplasia, Metaplasia, Dysplasia (with real-world clinical examples). Causes of cell injury (hypoxia, free radicals, chemical agents). Irreversible vs. Reversible cell injury (Apoptosis vs. Necrosis – types & triggers). Module 2: Inflammation & Immunity The vascular and cellular stages of acute inflammation. Key players: Histamine, Prostaglandins, Leukotrienes, Cytokines (TNF-α, Interleukins). Chronic inflammation vs. Granulomatous inflammation (TB, Sarcoidosis). Fever pathogenesis (Exogenous vs. Endogenous pyrogens) NUR 6121 EXAM 1 | QUESTIONS AND ANSWERS | SPRING 2026 UPDATE | 100% CORRECT - WILLIAM PATERSON UNIVERSITY. The nurse is reviewing assessment documentation of a client's wound and notes "purulent drainage". The nurse would interpret this as: A) Exudate containing large amounts of fibrinogen B) Exudate containing white blood cells, protein, and tissue debris C) Exudate that is water fluid, low in protein D) Exudate that resulted from leakage of red cells - ANSWER-B A client cuts herself with a sharp knife while cooking dinner. The client describes how the wound started bleeding and had a red appearance almost immediately. The nurse knows that in the vascular stage of acute inflammation, the vessels: A) Constrict as a result of "flight/flight" hormone release resulting in pale-colored skin B) Swell to the point of compromising circulation causing the limb to become cool to touch C) Bleed profusely until the body can compensate and start to send fibrinogen to the wound D) Vasodilate causing the area to become congested causing the red color and warmth - ANSWER-D A patient is experiencing anorexia, myalgia, arthralgia, headache, and fatigue. The nurse should assess for which of the following? A) Temperature B) Urinary output C) Respirations D) Hypothermia - ANSWER-A Evidence based first line pharmacological txs for insomnia include - ANSWER-use a short acting benzodiazepine receptor agonist Which class of drug represents the first choice for the management of both depression and chronic anxiety? - ANSWER-SSRI

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NUR 6121 EXAM 1 | QUESTIONS AND ANSWERS |
SPRING 2026 UPDATE | 100% CORRECT -
WILLIAM PATERSON UNIVERSITY.
The nurse is reviewing assessment documentation of a client's wound and notes
"purulent drainage". The nurse would interpret this as:
A) Exudate containing large amounts of fibrinogen
B) Exudate containing white blood cells, protein, and tissue debris
C) Exudate that is water fluid, low in protein
D) Exudate that resulted from leakage of red cells - ANSWER-B

A client cuts herself with a sharp knife while cooking dinner. The client describes
how the wound started bleeding and had a red appearance almost immediately. The
nurse knows that in the vascular stage of acute inflammation, the vessels:
A) Constrict as a result of "flight/flight" hormone release resulting in pale-colored
skin
B) Swell to the point of compromising circulation causing the limb to become cool
to touch
C) Bleed profusely until the body can compensate and start to send fibrinogen to
the wound
D) Vasodilate causing the area to become congested causing the red color and
warmth - ANSWER-D

A patient is experiencing anorexia, myalgia, arthralgia, headache, and fatigue. The
nurse should assess for which of the following?
A) Temperature
B) Urinary output
C) Respirations
D) Hypothermia - ANSWER-A

Evidence based first line pharmacological txs for insomnia include - ANSWER-
use a short acting benzodiazepine receptor agonist

Which class of drug represents the first choice for the management of both
depression and chronic anxiety? - ANSWER-SSRI

,Which of the following meds can be used in tx a patient in opioid withdrawal -
ANSWER-methadone and clonidine

DSM 5 criteria for substance tolerance/ dependence includes - ANSWER-
diminished effect with the same amount of substance used

You suspect that a patient has vitamin B-12 deficiency anemia and folate
deficiency anemia. In addition to checking vit B12 and folate levels, which other
BW will confirm your diagnosis - ANSWER-MMA levels

When treating a 25-year-old woman for mild anxiety, appropriate initial includes -
ANSWER-referral to mental health services including cognitive behavioral
therapy

In prescribing benzodiazepines, the NP considers that - ANSWER-these drugs
have a high potential abuse and the onset of therapeutic effect is usually rapid

Tx recommendations for depression should always include - ANSWER-cognitive
behavioral therapy

The NP knows that the full therapeutic effect of SSRI used for the treatment of
depression/ anxiety may take - ANSWER-12 weeks

When assessing the patient for IVP, the provider should always - ANSWER-
screen patients presenting for PCP visit

Appropriate txs for insomnia include all of the following - ANSWER-encourage
patients to have a regular bed/ awake times, use of sleep machine that
provides white noise, limiting alcohol and caffeine

A patient who has been symptomatic for a few weeks has a positive 2 step
serologic test for Lyme disease. He was started on the appropriate management on
the Np for this patient? - ANSWER-Refer for a lumbar puncture to evaluate
for CStt involvement and IV antibiotic

,A patient with anemia has the following labs: HGB: 10.2, HCT 33.1, MCV 113,
MCH37, B12320, serum folate 1.2. You should start the patient on - ANSWER-
ttoltx 1 tab BID

A patient with anemia labs: HGB 10.2, HCT 33.1, MCV 110, MCH 37, also
exhibits distal paresthesia. These findings would increase your suspicion for -
ANSWER-Vitamin B12 anemia

A patient has been determined to have VItB12 deficiency anemia. What additional
Bw would be appropriate to order? - ANSWER-Anti itt antibodies, schilling test

72-year-old nursing home patient presents with sudden onset fever, cough and
nasal congestion, there has been increased influenza activity in the facility. The
patient has COPD. Which medication would be your first choice - ANSWER-
Tamiflu 75 PO BIDx5 days

An 82-year-old nursing home resident has been diagnosed with influenza. Her
roommate, who is 86 years old, is concerned. She has not received the flu vaccine.
She has no symptoms but wants to know if she should get tx also. Based on CDC
recommendations what your approach for the roommate is - ANSWER-Start
tamiflu 75mg ODx 10 days

A patient with severe iron deficiency anemia is eating ice chips. Which term
should the clinician use to document this finding
A. Cheilosis
B. Anorexia
C. Hypochromasia
D. Pica - ANSWER-D. Pica

What is the most common cause of microcytic anemia
A. Anemia of chronic disease
B. Sideroblastic anemia
C. Iron deficiency anemia
D. Pernicious anemia - ANSWER-C. Iron deficiency anemia

Which symptom is the cardinal subjective symptom of sickle cell crisis
A. Pain

, B. Nausea
C. Lightheadedness
D. Palpitations - ANSWER-A. pain

A 52-year-old man presents with a routine work-related health assessment. He has
no complaints. His physical exam is normal. His routine CBC reveals HBG 11.1,
HCT 37.5, MCV 70. The patients lack of symptoms and physical findings -
ANSWER-is not unusual given the degree of anemia

A 68-year-old man with no past medical history and who is usually healthy
presents with symptoms of dyspnea during exercise for the past 2 weeks. His labs
show: HGB 9.8, HCT 28.9, MCV 82. What is the most likely cause of the finding?
- ANSWER-Occult blood loss

A patient has IDA. In treating the patient with supplemental Iron, which of the
following is true? - ANSWER-The bioavailability of supplemental iron is
increased with vitamin C

A patient presents with a tick bite. He noticed it today and removed the tick. He
thinks it occurred 2 days ago since that was the only time he was outdoors when he
was hiking in the Poconos. The patient has no symptoms. Based on guidelines,
how would the NP manage the patient - ANSWER-start doxycycline 200mg POx1

Patient presentation possibly common to anxiety and depression includes -
ANSWER-agitation

The common co morbidity associated with depression is - ANSWER-anxiety

A 65-year-old female has been on lorazepam for 6 years and wishes to stop. You
advise her that - ANSWER-she needs to taper her dose down with supervision


A 45-year-old female presents to the office with chronic racing thoughts, mild
headaches 2-3 days a week, insomnia and difficulty concentrating. Your diagnosis
would include - ANSWER-general anxiety disorder

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