FNP Certification Exam Study
Guide – Practice Questions
with Verified Answers With
Rationales. GRADED A+. Latest
2026/2027 Update.
In the person with reactive thrombocytosis, clotting risk is typically absent
until a platelet count of:
a. ≥400,000 mm3
b. ≥800,000 mm3.
c. ≥1 million mm3.
d. ≥2 million mm3.
C. ≥1 million mm3.
Reactive thrombocytosis is an increase in platelet count in response to a
stimulus. There are several causes of reactive thrombocytosis, including acute
bleeding and blood loss, allergic reactions, cancer, infections, some types of
anemia, major surgery, splenectomy, and some types of medications.
Treatment of reactive thrombocytosis is directed at the underlying cause and
platelet counts usually return to normal once the underlying condition is
brought under control. An increased risk of blood clots can occur once the
,platelet count is ≥1 million mm3 (NL = 150,000-450,000 mm3). Topic:
Assessment and Intervention in Select Hematologic Disorders
Antibodies are primarily formed by:
a. T-cell lymphocytes.
b. B-cell lymphocytes.
c. Mast cells.
d. Eosinophils.
B. B-cell lymphocytes.
B cells are involved in antibody formation. Delaying the hypersensitivity
response is a primary function of T-cell lymphocytes. Granulocytes and
monocytes are involved in the phagocytosis of circulating debris and
pathogens, such as bacteria or fungi. Topic: Assessment and Intervention in
Select Hematologic Disorders
Constitutional neutropenia is most often found in:
a. Those of African ancestry.
b. Sepsis recovery.
c. Post transfusion states.
d. Patients who have undergone splenectomy.
A. Those of African ancestry.
Constitutional neutropenia (also called benign ethnic neutropenia or benign
familial neutropenia) is a condition more often observed in people with African
and Middle Eastern ancestry. The condition is potentially caused by a defect in
the release of mature WBCs from the bone marrow to peripheral circulation.
Despite a consistently lower than normal ANC in people with constitutional
neutropenia, many do not show increased susceptibility to infection or any
other adverse effect. Topic: Assessment and Intervention in Select Hematologic
Disorders
Agranulocytosis is characterized by:
,a. Total WBC ≤8000 mm3.
b. Total WBC ≤5000 mm3.
c. ANC < 2000 mm3
d. ANC < 500 mm3
D. ANC < 500 mm3.
Neutropenia is characterized by an absolute neutrophil count (ANC) of <2000
mm3. Several factors can result in the development of neutropenia, including a
drug-induced reaction, nutritional deficiencies (e.g., vitamin B12, folate, or
copper), and hormone disorders (e.g., thyrotoxicosis, Addison disease, and
acromegaly). Severe neutropenia, or agranulocytosis, is defined as an ANC
<500 mm3 and places the patient at increased susceptibility to serious
bacterial infections. Topic: Assessment and Intervention in Select Hematologic
Disorders.
Eosinophilia is often seen in infections caused by:
a. Viruses.
b. Encapsulated bacteria.
c. Mycobacterium.
d. Protozoans.
D. Protozoans.
Eosinophils exhibit weak phagocytic action in the presence of foreign
substances and can ingest antigen-antibody complexes. These cells are active
against parasitic infections, such as protozoans, and if the parasite is too large
for ingestion, the cells can release substances directly onto the parasite's
surface. Neutrophils are active against bacteria while lymphocytes are active
against viral infections. Topic: Assessment and Intervention in Select
Hematologic Disorders
A WBC morphology report relates toxic granulation. This is most often seen
in:
, a. Pathogenic conditions are caused by intracellular organisms.
b. Viral illness.
c. Recovery stage from protozoan infestation.
d. Serious bacterial infection.
D. Serious bacterial infection.
Toxic granulation refers to a morphology observed in granulocytes, such as
neutrophils, that is characterized by the presence of dark, coarse granules. This
condition is commonly observed in patients during inflammation or acute
infection. Granulocytes are involved in the phagocytosis of bacterial or fungal
pathogens and, thus, toxic granulation is most likely a result of a serious
bacterial infection. Topic: Assessment and Intervention in Select Hematologic
Disorders
Which of the following is consistent with neutrophilia?
a. TWBC=8,000 mm3, 45% neuts
b. TWBC=13,500 mm3, 35% neuts
c. TWBC=10,100 mm3, 81% neuts
d. TWBC=12,000 mm3, 40% neuts
C. TWBC=10,100 mm3, 81% neuts.
Neutrophils are involved in the degradation of pathogens, generation of
oxidants, and tissue degradation. Neutrophilia can occur from acute infections
and is characterized by an elevated number of neutrophils (>70% TWBC
[NL=50%-70% TWBC in adults]). Leukocytosis with neutrophilia is characterized
by elevated levels of WBCs (NL = 6,000-10,000 per mm3 in adults). Topic:
Assessment and Intervention in Select Hematologic Disorders
The use of which of the following medications is a common cause of drug-
induced thrombocytopenia?
a. Warfarin
b. Aspirin
Guide – Practice Questions
with Verified Answers With
Rationales. GRADED A+. Latest
2026/2027 Update.
In the person with reactive thrombocytosis, clotting risk is typically absent
until a platelet count of:
a. ≥400,000 mm3
b. ≥800,000 mm3.
c. ≥1 million mm3.
d. ≥2 million mm3.
C. ≥1 million mm3.
Reactive thrombocytosis is an increase in platelet count in response to a
stimulus. There are several causes of reactive thrombocytosis, including acute
bleeding and blood loss, allergic reactions, cancer, infections, some types of
anemia, major surgery, splenectomy, and some types of medications.
Treatment of reactive thrombocytosis is directed at the underlying cause and
platelet counts usually return to normal once the underlying condition is
brought under control. An increased risk of blood clots can occur once the
,platelet count is ≥1 million mm3 (NL = 150,000-450,000 mm3). Topic:
Assessment and Intervention in Select Hematologic Disorders
Antibodies are primarily formed by:
a. T-cell lymphocytes.
b. B-cell lymphocytes.
c. Mast cells.
d. Eosinophils.
B. B-cell lymphocytes.
B cells are involved in antibody formation. Delaying the hypersensitivity
response is a primary function of T-cell lymphocytes. Granulocytes and
monocytes are involved in the phagocytosis of circulating debris and
pathogens, such as bacteria or fungi. Topic: Assessment and Intervention in
Select Hematologic Disorders
Constitutional neutropenia is most often found in:
a. Those of African ancestry.
b. Sepsis recovery.
c. Post transfusion states.
d. Patients who have undergone splenectomy.
A. Those of African ancestry.
Constitutional neutropenia (also called benign ethnic neutropenia or benign
familial neutropenia) is a condition more often observed in people with African
and Middle Eastern ancestry. The condition is potentially caused by a defect in
the release of mature WBCs from the bone marrow to peripheral circulation.
Despite a consistently lower than normal ANC in people with constitutional
neutropenia, many do not show increased susceptibility to infection or any
other adverse effect. Topic: Assessment and Intervention in Select Hematologic
Disorders
Agranulocytosis is characterized by:
,a. Total WBC ≤8000 mm3.
b. Total WBC ≤5000 mm3.
c. ANC < 2000 mm3
d. ANC < 500 mm3
D. ANC < 500 mm3.
Neutropenia is characterized by an absolute neutrophil count (ANC) of <2000
mm3. Several factors can result in the development of neutropenia, including a
drug-induced reaction, nutritional deficiencies (e.g., vitamin B12, folate, or
copper), and hormone disorders (e.g., thyrotoxicosis, Addison disease, and
acromegaly). Severe neutropenia, or agranulocytosis, is defined as an ANC
<500 mm3 and places the patient at increased susceptibility to serious
bacterial infections. Topic: Assessment and Intervention in Select Hematologic
Disorders.
Eosinophilia is often seen in infections caused by:
a. Viruses.
b. Encapsulated bacteria.
c. Mycobacterium.
d. Protozoans.
D. Protozoans.
Eosinophils exhibit weak phagocytic action in the presence of foreign
substances and can ingest antigen-antibody complexes. These cells are active
against parasitic infections, such as protozoans, and if the parasite is too large
for ingestion, the cells can release substances directly onto the parasite's
surface. Neutrophils are active against bacteria while lymphocytes are active
against viral infections. Topic: Assessment and Intervention in Select
Hematologic Disorders
A WBC morphology report relates toxic granulation. This is most often seen
in:
, a. Pathogenic conditions are caused by intracellular organisms.
b. Viral illness.
c. Recovery stage from protozoan infestation.
d. Serious bacterial infection.
D. Serious bacterial infection.
Toxic granulation refers to a morphology observed in granulocytes, such as
neutrophils, that is characterized by the presence of dark, coarse granules. This
condition is commonly observed in patients during inflammation or acute
infection. Granulocytes are involved in the phagocytosis of bacterial or fungal
pathogens and, thus, toxic granulation is most likely a result of a serious
bacterial infection. Topic: Assessment and Intervention in Select Hematologic
Disorders
Which of the following is consistent with neutrophilia?
a. TWBC=8,000 mm3, 45% neuts
b. TWBC=13,500 mm3, 35% neuts
c. TWBC=10,100 mm3, 81% neuts
d. TWBC=12,000 mm3, 40% neuts
C. TWBC=10,100 mm3, 81% neuts.
Neutrophils are involved in the degradation of pathogens, generation of
oxidants, and tissue degradation. Neutrophilia can occur from acute infections
and is characterized by an elevated number of neutrophils (>70% TWBC
[NL=50%-70% TWBC in adults]). Leukocytosis with neutrophilia is characterized
by elevated levels of WBCs (NL = 6,000-10,000 per mm3 in adults). Topic:
Assessment and Intervention in Select Hematologic Disorders
The use of which of the following medications is a common cause of drug-
induced thrombocytopenia?
a. Warfarin
b. Aspirin
