PHM 104 FINAL EXAM - QUESTIONS AND ANSWERS | SOLVED 100% CORRECT.
prostacyclin derivatives, endothelin antagonists, activators of soluble guanylate cyclase, PDE5 inhibitors
- (answer)drugs used to treat PAH
Uptravi - (answer)prostacyclin derivative
MOA of Uptravi - (answer)vasodilation, antiproliferative, inhibit platelet aggregation, antithrombotic,
anti-inflammatory
bosentan, sitaxentan, ambrisentan (Letairis) - (answer)endothelin antagonists
MOA of endothelin antagonists - (answer)block endothelin A receptor, leading to vasodilation
cinaciguat, riociguat - (answer)activators of soluble guanylate cyclase
MOA of activators of soluble guanylate cyclase - (answer)stimulator of sGC, elevates nitric oxide, causing
vasodilation
Viagra, Cialis - (answer)PDE5 ihibitors
MOA of PDE5 inhibitors - (answer)inhibit PDE5, increase cGMP levels
ivacaftor, tezcaftor, lumacaftor - (answer)drugs used to treat CF
MOA of ivacaftor - (answer)potentiator of CFTR
MOA of tezcaftor - (answer)repairs misfolded components of CFTR
MOA of lumacaftor - (answer)"chaperone" function prevents misfolding of CFTR proteins
,PHM 104 FINAL EXAM - QUESTIONS AND ANSWERS | SOLVED 100% CORRECT.
phosphodiesterase inhibitors, anticholinergics - (answer)drugs used to treat COPD
roflumilast (Daliresp), cilomilast - (answer)PDE4 inhibitors
theophylline - (answer)nonselective PDE inhibitor
MOA of phosphodiesterase inhibitors - (answer)anti-inflammatory actions
MOA of roflumilast - (answer)weak bronchodilators that reduce inflammation, crosses BBB
MOA of cilomilast - (answer)more powerful anti-inflammatory than roflumilast, does not cross BBB
tiotropium (Spiriva), Tuzadora, revefenacin - (answer)anticholinergics
MOA of anticholinergics - (answer)bind to M3 receptor, causing mild bronchodilation and mucus volume
reduction
codeine, benzonatate, tetracaine, dextromethorphan - (answer)antitussives
MOA of codeine - (answer)work in the brain to suppress cough
MOA of benzonatate and tetracaine (local anesthetics) - (answer)locally anesthetizes C fibers, blocks
voltage gated sodium channels
MOA of dextromethorphan - (answer)opiate agonist and NMDA antagonist
What drug does not cause false positives for opiates but will cause false positives for PCP? -
(answer)dextromethorphan
, PHM 104 FINAL EXAM - QUESTIONS AND ANSWERS | SOLVED 100% CORRECT.
uses of antihistamines - (answer)hay fever, allergic rhinitis, eczema, allergic conjunctivitis, sneezing,
urticaria, allergic reactions caused by food allergies, insomnia, motion sickness, Parkinson's
diphenhydramine (Benadryl), dimenhydrinate, doxylamine, carbinoxamine - (answer)ethanolamine
antihistamines
Which antihistamines have the highest antimuscarinic/anticholinergic potential and have the greatest
risk of sleepiness? - (answer)ethanolamine antihistamines
uses of diphenhydramine (Benadryl) - (answer)insomnia, motion sickness, Parkinson's
Which drug is both an ethanolamine antihistamine and 1st generation antihistamine? -
(answer)diphenhydramine
True/False: 1st generation antihistamines do not cross the BBB. - (answer)False, 1st generation
antihistamines cross the BBB.
True/False: 2nd generation antihistamines do not cross the BBB. - (answer)True
Which antihistamines do not cross the BBB, have a lower toxicity after OD, and have a slow dissociation
from the H1 receptor? - (answer)2nd generation antihistamines
What do 1st generation antihistamines and 2nd generation antihistamines have in common? -
(answer)anticholinergic, anti-serotonin, alpha receptor blocking
tripelenamine, pyrilamine - (answer)ethylenediamine antihistamines
Which antihistamines have greater specificity and greater somnolence? - (answer)ethylenediamine
antihistamines
chlorpheniramine, brompheniramine - (answer)alkylamine antihistamines
prostacyclin derivatives, endothelin antagonists, activators of soluble guanylate cyclase, PDE5 inhibitors
- (answer)drugs used to treat PAH
Uptravi - (answer)prostacyclin derivative
MOA of Uptravi - (answer)vasodilation, antiproliferative, inhibit platelet aggregation, antithrombotic,
anti-inflammatory
bosentan, sitaxentan, ambrisentan (Letairis) - (answer)endothelin antagonists
MOA of endothelin antagonists - (answer)block endothelin A receptor, leading to vasodilation
cinaciguat, riociguat - (answer)activators of soluble guanylate cyclase
MOA of activators of soluble guanylate cyclase - (answer)stimulator of sGC, elevates nitric oxide, causing
vasodilation
Viagra, Cialis - (answer)PDE5 ihibitors
MOA of PDE5 inhibitors - (answer)inhibit PDE5, increase cGMP levels
ivacaftor, tezcaftor, lumacaftor - (answer)drugs used to treat CF
MOA of ivacaftor - (answer)potentiator of CFTR
MOA of tezcaftor - (answer)repairs misfolded components of CFTR
MOA of lumacaftor - (answer)"chaperone" function prevents misfolding of CFTR proteins
,PHM 104 FINAL EXAM - QUESTIONS AND ANSWERS | SOLVED 100% CORRECT.
phosphodiesterase inhibitors, anticholinergics - (answer)drugs used to treat COPD
roflumilast (Daliresp), cilomilast - (answer)PDE4 inhibitors
theophylline - (answer)nonselective PDE inhibitor
MOA of phosphodiesterase inhibitors - (answer)anti-inflammatory actions
MOA of roflumilast - (answer)weak bronchodilators that reduce inflammation, crosses BBB
MOA of cilomilast - (answer)more powerful anti-inflammatory than roflumilast, does not cross BBB
tiotropium (Spiriva), Tuzadora, revefenacin - (answer)anticholinergics
MOA of anticholinergics - (answer)bind to M3 receptor, causing mild bronchodilation and mucus volume
reduction
codeine, benzonatate, tetracaine, dextromethorphan - (answer)antitussives
MOA of codeine - (answer)work in the brain to suppress cough
MOA of benzonatate and tetracaine (local anesthetics) - (answer)locally anesthetizes C fibers, blocks
voltage gated sodium channels
MOA of dextromethorphan - (answer)opiate agonist and NMDA antagonist
What drug does not cause false positives for opiates but will cause false positives for PCP? -
(answer)dextromethorphan
, PHM 104 FINAL EXAM - QUESTIONS AND ANSWERS | SOLVED 100% CORRECT.
uses of antihistamines - (answer)hay fever, allergic rhinitis, eczema, allergic conjunctivitis, sneezing,
urticaria, allergic reactions caused by food allergies, insomnia, motion sickness, Parkinson's
diphenhydramine (Benadryl), dimenhydrinate, doxylamine, carbinoxamine - (answer)ethanolamine
antihistamines
Which antihistamines have the highest antimuscarinic/anticholinergic potential and have the greatest
risk of sleepiness? - (answer)ethanolamine antihistamines
uses of diphenhydramine (Benadryl) - (answer)insomnia, motion sickness, Parkinson's
Which drug is both an ethanolamine antihistamine and 1st generation antihistamine? -
(answer)diphenhydramine
True/False: 1st generation antihistamines do not cross the BBB. - (answer)False, 1st generation
antihistamines cross the BBB.
True/False: 2nd generation antihistamines do not cross the BBB. - (answer)True
Which antihistamines do not cross the BBB, have a lower toxicity after OD, and have a slow dissociation
from the H1 receptor? - (answer)2nd generation antihistamines
What do 1st generation antihistamines and 2nd generation antihistamines have in common? -
(answer)anticholinergic, anti-serotonin, alpha receptor blocking
tripelenamine, pyrilamine - (answer)ethylenediamine antihistamines
Which antihistamines have greater specificity and greater somnolence? - (answer)ethylenediamine
antihistamines
chlorpheniramine, brompheniramine - (answer)alkylamine antihistamines
