CHEMOTHERAPY
MOA
FLASH CARDS
, SULFONAMIDES
Sulfonamides (Drug)
↓
S t r u c t u ra l a n a l o g u e o f PABA
↓
Competitive inhibition
↓
Inhibits enzyme:
Dihydropteroate synthase
↓
Blocks conversion:
PABA →
Dihydropteroic acid
↓
↓ Folic acid synthesi s
↓
↓ Te t ra hyd ro f o l a t e ( T H F )
↓
↓ Purine + Pyrimidine synthesis
↓
↓ DNA synthesis
↓
➡ B AC T E RI O S TAT I C E F F E C T
(Growth inhibition of bacteria)
MOA
FLASH CARDS
, SULFONAMIDES
Sulfonamides (Drug)
↓
S t r u c t u ra l a n a l o g u e o f PABA
↓
Competitive inhibition
↓
Inhibits enzyme:
Dihydropteroate synthase
↓
Blocks conversion:
PABA →
Dihydropteroic acid
↓
↓ Folic acid synthesi s
↓
↓ Te t ra hyd ro f o l a t e ( T H F )
↓
↓ Purine + Pyrimidine synthesis
↓
↓ DNA synthesis
↓
➡ B AC T E RI O S TAT I C E F F E C T
(Growth inhibition of bacteria)
