PRACTICE QUESTIONS AND RELIABLE
ANSWERS FULL REVIEW GRADED A+
⩥ Cytotoxic agents include 2 types. Answer: Vesicant: severe &
irreversible damage, resulting in necrosis;
Irritant: local inflammation, unlikely to cause permanent damage
⩥ Extravasation injury depends on. Answer: Type, Concentration &
Quantity (Leakage & Involuntary injection)
Need adequate guideline, training & correct treatment
⩥ Central/ Hickman. Answer: Allow for multiple administration, single
insertion under anesthesia & painless during infusion
⩥ Hickman line destination. Answer: Superior vena cava near right
atrium
⩥ Hickman line complication. Answer: Hemorrhage, thrombosis,
infection
⩥ 4 major systemic effects. Answer: Nausea & Vomiting,
Myelosuppression, Mucositis, Hair loss
, ⩥ Mechanism of CINV. Answer: 1) Direct activation of medullary
chemoreceptor trigger zone (5-HT3, Dopamine)
2) Cell damage of GI tract, serotonin releases, activate 5-HT3 receptors,
send impulse to medulla, stimulate vomiting centre
⩥ CINV medications. Answer: 1) Dopamine antagonist-
Metoclopramide
2) 5-HT3 antagonist- Ondansetron
3) Corticosteroid- Dexamthasone
⩥ Myelosuppression leads to immunosuppression. Answer: Anaemia,
Neutropenia, Thrombocytopenia
⩥ Grade I and II oral mucositis. Answer: Grade I: painless ulcer,
erythema, mild soreness in absence of lesion
Grade II: painful ulcer, erythema, edema but can eat & shallow
⩥ Grade III and IV oral mucositis. Answer: Grade III: painful ulcer,
erythema, edema requiring IV hydration
Grade IV: severe ulceration, require parenteral nutritional support/
prophylactic intubation
⩥ Good mouth care. Answer: 1) Avoid spirits & spices