Test Bank For
Integrated Cardiopulmonary Pharmacology Seventh Edition Bruce Colbert, Adam James
Chapters 1-15 Answers are at the End of Each Chapter
Chapter 1
MULTIPLE CHOICE
Choose the one alternative that best completes the statement or answers the question.
1. Which term best describes the study of drugs and their action on the body?
a. Therapeutics
b. Pharmacology
c. Pharmacotherapy
d. Disease management
2. The most common source of drugs today is:
a. Plants.
b. Animals.
c. Chemical synthesis.
d. Genetic bioengineering.
3. The agency that regulates drug testing and approves new drugs is the:
a. Center for Drug Evaluation and Research (CDER).
b. Centers for Disease Control and Prevention (CDC).
c. National Institutes of Health (NIH).
d. Food and Drug Administration (FDA).
4. The phase of drug testing that is performed to look for rare or serious adverse effects after
the drug is marketed is:
a. Phase I.
b. Phase II.
c. Phase III.
d. Phase IV.
5. What organization is officially responsible for establishing public standards that approved
drugs must continue to meet?
a. The Physicians‟ Desk Reference (PDR)
b. The American Hospital Formulary Service (AHFS)
c. The United States Pharmacopeia (USP)
d. The Food and Drug Administration (FDA)
,6. The name given to a drug that is considered the nonproprietary name and is not owned by
any particular pharmaceutical company is the:
a. Chemical name.
b. Generic name.
c. Trade name.
d. Brand name.
.
7. A 21-year-old pregnant female has been exposed to the drug Virazole, which has been
reported to cause damage to the fetus. This type of drug exposure is referred to as:
a. An adverse drug reaction (ADR).
b. A life-threatening reaction.
c. Hypersensitivity.
d. Teratogenicity.
8. Drugs that do not go directly into the systemic circulation after being absorbed and are
metabolized through the liver describes a:
a. Steady state.
b. First-pass effect.
c. Therapeutic range.
d. Half-life.
9. A physician would like a patient to receive acetaminophen via the enteral route. Your
choice of administration may include:
I. Oral.
II. Nasogastric.
III. Rectal.
a. I
b. I and II
c. I and III
d. I, II, and III
10. Administration of 80 mg propranolol given orally (PO) produces the same response as 1
mg intravenously (IV). The difference in dosage is explained by:
a. The first-pass effect.
b. Bioavailability.
c. Protein binding.
d. Metabolism.
11. The most common and convenient route of drug administration is:
a. Oral.
b. Inhalation.
c. Sublingual.
d. Transdermal.
,12. A malnourished patient is susceptible to an increase in drug response because of all
except which of the following?
a. A malnourished patient has less serum albumin.
b. The free, unbound drug is an active drug and will lead to greater drug response.
c. Less drug is absorbed systemically.
d. Much of the drug will be free within the bloodstream.
13. The effect of administering a water-soluble drug to an infant, who has a higher
percentage of total body water compared to an adult, would be:
a. Decreased effect.
b. The same effect.
c. Increased effect.
d. An additive effect.
14. The mechanisms responsible for metabolism of rifampin in the liver include:
I. Drug oxidation.
II. Enzyme inhibition.
III. The cytochrome P-450 system.
a. I and II
b. I and III
c. II and III
d. I, II, and III
15. After drugs are metabolized, they can be eliminated from the body through the:
a. Skin.
b. Lungs.
c. Feces and urine.
d. All of the above.
16. The potency of a drug is best described as:
a. An affinity of the drug for a particular receptor site.
b. The degree in which the drug can be cleared from the body.
c. The route of the drug.
d. The amount of drug required to produce the response desired.
17. Excretion of drugs through the kidneys is affected by all except which of the following?
a. Glomerular filtration
b. Drug oxidation
c. Impaired renal function
d. Tubular secretion and reabsorption
18. When a drug binds to a receptor site, all except which of the following can occur?
a. An ion channel can be opened or closed.
b. Biochemical messengers that initiate chemical reactions can be activated.
c. A normal cellular function can be turned on or off.
, d. The therapeutic response produced is directly proportional to the number of sites
occupied.
19. A drug that does not elicit a response:
a. Is an agonist.
b. Increases drug action.
c. Is an antagonist.
d. Activates the receptor.
20. A cell that becomes less responsive to a drug after exposure over time is a condition
called:
a. Tolerance.
b. Desensitization.
c. Dependence.
d. Low therapeutic index.
21. You note that a physician has made a new entry on a patient‟s chart. The entry reads “500
mg acetaminophen PO QID.” What does this order mean?
a. 500 mg acetaminophen by mouth, four times daily
b. 500 mg acetaminophen per order, six times daily
c. 500 mg acetaminophen preop, then daily
d. 500 mg acetaminophen postop, then every 4 hours
22. Which of the following routes of drug administration completely bypasses the absorption
step before entering the bloodstream?
a. Oral
b. Rectal
c. Intravenous
d. Intramuscular
23. To maintain a steady state of drug concentration in the plasma, a drug should be
administered by which of the following methods?
a. Intramuscular injection
b. Continuous IV infusion
c. Intravenous bolus
d. Transdermally
24. Which of the following terms explains why a patient may require an increased amount of
a drug after repeated use to produce the same therapeutic effect?
a. Dependence
b. Selectivity
c. Tachyphylaxis
d. Tolerance
25. Treatment for drug overdoses and poisoning includes all of the following except the:
Integrated Cardiopulmonary Pharmacology Seventh Edition Bruce Colbert, Adam James
Chapters 1-15 Answers are at the End of Each Chapter
Chapter 1
MULTIPLE CHOICE
Choose the one alternative that best completes the statement or answers the question.
1. Which term best describes the study of drugs and their action on the body?
a. Therapeutics
b. Pharmacology
c. Pharmacotherapy
d. Disease management
2. The most common source of drugs today is:
a. Plants.
b. Animals.
c. Chemical synthesis.
d. Genetic bioengineering.
3. The agency that regulates drug testing and approves new drugs is the:
a. Center for Drug Evaluation and Research (CDER).
b. Centers for Disease Control and Prevention (CDC).
c. National Institutes of Health (NIH).
d. Food and Drug Administration (FDA).
4. The phase of drug testing that is performed to look for rare or serious adverse effects after
the drug is marketed is:
a. Phase I.
b. Phase II.
c. Phase III.
d. Phase IV.
5. What organization is officially responsible for establishing public standards that approved
drugs must continue to meet?
a. The Physicians‟ Desk Reference (PDR)
b. The American Hospital Formulary Service (AHFS)
c. The United States Pharmacopeia (USP)
d. The Food and Drug Administration (FDA)
,6. The name given to a drug that is considered the nonproprietary name and is not owned by
any particular pharmaceutical company is the:
a. Chemical name.
b. Generic name.
c. Trade name.
d. Brand name.
.
7. A 21-year-old pregnant female has been exposed to the drug Virazole, which has been
reported to cause damage to the fetus. This type of drug exposure is referred to as:
a. An adverse drug reaction (ADR).
b. A life-threatening reaction.
c. Hypersensitivity.
d. Teratogenicity.
8. Drugs that do not go directly into the systemic circulation after being absorbed and are
metabolized through the liver describes a:
a. Steady state.
b. First-pass effect.
c. Therapeutic range.
d. Half-life.
9. A physician would like a patient to receive acetaminophen via the enteral route. Your
choice of administration may include:
I. Oral.
II. Nasogastric.
III. Rectal.
a. I
b. I and II
c. I and III
d. I, II, and III
10. Administration of 80 mg propranolol given orally (PO) produces the same response as 1
mg intravenously (IV). The difference in dosage is explained by:
a. The first-pass effect.
b. Bioavailability.
c. Protein binding.
d. Metabolism.
11. The most common and convenient route of drug administration is:
a. Oral.
b. Inhalation.
c. Sublingual.
d. Transdermal.
,12. A malnourished patient is susceptible to an increase in drug response because of all
except which of the following?
a. A malnourished patient has less serum albumin.
b. The free, unbound drug is an active drug and will lead to greater drug response.
c. Less drug is absorbed systemically.
d. Much of the drug will be free within the bloodstream.
13. The effect of administering a water-soluble drug to an infant, who has a higher
percentage of total body water compared to an adult, would be:
a. Decreased effect.
b. The same effect.
c. Increased effect.
d. An additive effect.
14. The mechanisms responsible for metabolism of rifampin in the liver include:
I. Drug oxidation.
II. Enzyme inhibition.
III. The cytochrome P-450 system.
a. I and II
b. I and III
c. II and III
d. I, II, and III
15. After drugs are metabolized, they can be eliminated from the body through the:
a. Skin.
b. Lungs.
c. Feces and urine.
d. All of the above.
16. The potency of a drug is best described as:
a. An affinity of the drug for a particular receptor site.
b. The degree in which the drug can be cleared from the body.
c. The route of the drug.
d. The amount of drug required to produce the response desired.
17. Excretion of drugs through the kidneys is affected by all except which of the following?
a. Glomerular filtration
b. Drug oxidation
c. Impaired renal function
d. Tubular secretion and reabsorption
18. When a drug binds to a receptor site, all except which of the following can occur?
a. An ion channel can be opened or closed.
b. Biochemical messengers that initiate chemical reactions can be activated.
c. A normal cellular function can be turned on or off.
, d. The therapeutic response produced is directly proportional to the number of sites
occupied.
19. A drug that does not elicit a response:
a. Is an agonist.
b. Increases drug action.
c. Is an antagonist.
d. Activates the receptor.
20. A cell that becomes less responsive to a drug after exposure over time is a condition
called:
a. Tolerance.
b. Desensitization.
c. Dependence.
d. Low therapeutic index.
21. You note that a physician has made a new entry on a patient‟s chart. The entry reads “500
mg acetaminophen PO QID.” What does this order mean?
a. 500 mg acetaminophen by mouth, four times daily
b. 500 mg acetaminophen per order, six times daily
c. 500 mg acetaminophen preop, then daily
d. 500 mg acetaminophen postop, then every 4 hours
22. Which of the following routes of drug administration completely bypasses the absorption
step before entering the bloodstream?
a. Oral
b. Rectal
c. Intravenous
d. Intramuscular
23. To maintain a steady state of drug concentration in the plasma, a drug should be
administered by which of the following methods?
a. Intramuscular injection
b. Continuous IV infusion
c. Intravenous bolus
d. Transdermally
24. Which of the following terms explains why a patient may require an increased amount of
a drug after repeated use to produce the same therapeutic effect?
a. Dependence
b. Selectivity
c. Tachyphylaxis
d. Tolerance
25. Treatment for drug overdoses and poisoning includes all of the following except the:
