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How is Alzheimer's treated?
- There is no cure, but there are pharmacological and
non-pharmacological treatments
- Cholinesterase inhibitors
- Memantine (namenda)
What are some physical changes from
Alzheimer's dementia?
,- Brain shrinks dramatically; nerve cell death and
tissue loss
- Cardinal signs: plaques (abnormal clusters of
protein fragments) and tangles (twisted strands of
another protein)
What does cholinesterase inhibitors do?
- Prevent the breakdown of acetylcholine, a chemical
messenger that is important for learning and memory
- Supports communication among nerve cells by
keeping the acetylcholine high
What are cholinesterase inhibitors prescribed
for?
- To treat symptoms related to memory, thinking,
language, judgment, and other processes
- Helps delay or slow the worsening of symptoms
,What are some commonly prescribed
cholinesterase inhibitors?
- Donepezil (aricept)
- Galantamine (razadyne)
- Rivastigmine (exeleon)
Which cholinesterase inhibitor can be used for all
stages of Alzheimer's?
- Donepezil (aricept)
Which cholinesterase inhibitor can be used for
mild-to-moderate stages of Alzheimer's?
- Galantamine (razadyne)
- Rivastigmine (exeleon)
Which cholinesterase inhibitor can be used for
mild-to-moderate Alzheimer's and Parkinson's?
- Rivastigmine (exeleon)
What medication combination is used to treat
moderate-to-severe Alzheimer's?
, - Memantine (namenda) and donepezil (aricept)
What is memantine (namenda) used for?
- Prescribed to improve memory, attention, reason,
language, and the ability to perform simple tasks
- Can be used alone or with other Alzheimer's
disease treatments
How does memantine (namenda) work?
- Regulates the activity of glutamate, a chemical
involved in information processing, storage, and
retrieval
- Improves mental functioning and ability to perform
daily activities for some people
What is the difference in MOA between
cholinesterase inhibitors and memantine
(namenda)?