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Approach to a patient with chest pain

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This document provides a structured overview of the clinical approach to evaluating a patient presenting with chest pain, including differential diagnoses, risk factors, and diagnostic criteria. It covers cardiovascular and non-cardiovascular causes, ECG interpretation, cardiac biomarkers, and key clinical examination findings. The notes also include practical insights into anginal pain characteristics, STEMI precautions, and emergency department decision-making.

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Approach to a patient with
chest pain
Terminology: Chest pain vs Precordial pain
Precordial pain: precordium includes the whole skin area in front of the
heart plus the whole area in which anginal pain may be radiating to, this
includes: anterior chest wall, neck and jaw, shoulders and arms, and
epigastric area.

Chest pain causes
Cardiovascular
Coronary artery disease

Stable coronary artery: chronic disease chest pain provoked by
exertion (due to the presence of a stable plaque with exertion causes
supply/demand mismatch → ischemia → resulting in chest pain) and
relived by rest → not considered a CAD anymore?

ST elevation MI (STEMI): the presence of a persistent ST elevation
(measured at the J-point) ≥ 1 mm in 2 or more contiguous leads with the
presence of ischemic symptoms (or ≥ 2.5 mm in men < 40 years, 2 mm
in men > 40 years, or 1.5 mm in women leads V2-V3) in the absence of
LVH or LBBB

Non-ST elevation MI (NSTEMI): the presence of ischemic symptoms
without no persistent ST elevation on ECG however the ECG might
show : ST depression, T-wave inversion, normal ECG, stuttering
course.

Acute aortic syndrome

Severe agonizing tearing pain that is maximal at the start then
decreases, usually radiating to the back.

It can propagate to the abdomen if the pathology involves the
abdominal aorta

atypical chest pain but could present as typical if the dissection flap
causes occlusion of the coronary ostium




Approach to a patient with chest pain 1

, Types:
Aortic dissection - Stanford type A and type B

Intramural hematoma (IMH)

Penetrating aortic ulcer

Other cardiovascular causes

Pulmonary embolism

Myocarditis: mimics STEMI pain and is associated with ST elevation

pericarditis
Non-cardiovascular
Chest

Pneumonia

Pleurisy

Myositis

Costochondritis

Esophageal

Esophageal spasm → relived by nitrates (just like angina)

GERD

Esophagitis

Cutaneous

Pre/post-herpetic neuralgia → Anginal pain that doesn’t cross the
mid-line (to differentiate it from other causes)

⚡ Note that: most anginal pain crosses the mid-line
Breast disease e.g. fibroadenosis

Joint

Frozen shoulder syndrome.

Arthritis.
Risk factors



Approach to a patient with chest pain 2

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Uploaded on
April 24, 2026
File latest updated on
April 24, 2026
Number of pages
14
Written in
2025/2026
Type
Class notes
Professor(s)
Emad magdy shawky
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