Conditions (Part I Cardiovascular System)
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Why would hyperthyroidism put a person at risk for secondary Dyslipidemia? -
ANSWERS-Hyperthyroidism slows down the metabolism and reduced the production of
LDL receptors, without these receptors LDLs linger in the blood causing a build up
What is the role of lipoproteins? - ANSWERS-Manufacture and repair plasma
membranes and cholesterol needed for bile salts and steroid hormones
What do very low density lipoproteins (VLDL) indicate about a person's cardiovascular
risk? - ANSWERS-Future coronary events
What do low density lipoproteins indicate about a persons cardiovascular risk? -
ANSWERS-They Indicate coronary risk in the context of factors like age, diabetes,
chronic kidney disease
What do high density lipoproteins indicate about a person cardiovascular risk? -
ANSWERS-HDL are protective against atherosclerosis. They can remove excess
cholesterol from arterial walls
What is the first step of the Pathophysiology of atherosclerosis and what occurs? -
ANSWERS-Injury to endothelium will trigger and inflammatory response where
monocytes and platelets travel to the site of injury
,I'm the second step of the Pathophysiology of atherosclerosis LDL enter the intimal
layer of the vessel, engulfed LDLs form _____ and leave ____ deposits. - ANSWERS-
Foams Cells, Fatty Streaks
During the third step in the Pathophysiology of atherosclerosis what is the result of
persistent inflammatory process in response to the fatty streak? - ANSWERS-Plaque is
formed as a result of smooth muscle collagen forming over the fatty streaks
In the final step of the Pathophysiology of atherosclerosis what occurs with Unstable
plaques? - ANSWERS-The unstable plaque ruptures, the clotting cascade is activated
and platelets come to form a thrombus that could cause ischemia or infarction
What abbreviation represents the flow of blood to the lungs? - ANSWERS-QP
What abbreviation represents the flow of blood to the body? - ANSWERS-QS
Does Pulmonary Vascular Resistance (PVR) increase or decrease as you age and
why? - ANSWERS-Pulmonary Vascular Resistance decreases as you age because as
your lungs become more developed, there is less resistance to accomplish breathing.
Does Systemic Vascular Resistance (SVR) increase or decrease as you age and why?
- ANSWERS-Systemic vascular resistance increases as you age because as you get
older and larger your heart has to work harder to push blood through a larger body.
What factors effect PVR and SVR? (5) - ANSWERS-Sympathetic Nervous System
Local tissue metabolism
Hormone responses
Changes in chemical environment
Compliance = change in Volume / change in pressure
, What factors contribute to the blood flow in a blood vessel? (4) - ANSWERS-Pressure
differences (a change in Pressure between two ends of a vessel)
Resistance (diameter of vessel)
Viscosity (how thick is the blood)
Length (how long is the vessel)
How does the amount of intercellular calcium effect contraction in the heart? -
ANSWERS-The greater the amount of intracellular calcium, the stronger the contraction
Explain the the proceeds of cardiac contraction and relaxation including the role of actin,
myosin, and troponin? - ANSWERS-Calcium interacts with tropinin C which causes
tropomyosin (draped around actin) to move this allowing actin and myosin to work
together to cause contraction
What is composed on the Myosin Filament/Myosin molecule? - ANSWERS-Tail: 2
polypeptide chains wrapped in a spiral forming a double helix
Head: globular peptide with associated light chains
The flexible hinge and arm connected to the myosin head (where myosin head bind to
actin) it called the ____? - ANSWERS-Cross body Bridge
What is the power stroke? - ANSWERS-The movement of myosin head while attached
to actin myofilament
The process of cardiac muscle contraction when the Z disc pulls filaments together at
the sarcomeres requires what to be put into action? - ANSWERS-ATP
How does Epinephrine effect the Cardiovascular System? - ANSWERS-Increases HR,
smooth muscle contraction, myocardial contractility, coronary flow, increases systolic
BP, mild increase in Diastolic BP.