Test Bank – Stevens's Clinical Immunology,
6th Edition by Linda E. Miller
The germinal centers found in the cortical region of lymph nodes and the peripheral region of
splenic periarteriolar lymphatic tissue: - answer-contains large populations of B lymphocytes
and plasma cells
Balance between TH1 and TH2 cell activation determines outcome of intracellular infections.
Thus, in case of Mycobacterium leprae infection: - answer-tuberculoid leprosy will occur in
patients with a prominent TH1 response
The initiation of T cell responses requires multiple receptors on the T cells recognizing ligands
on APCs. The MHC molecule located around the peptide-binding cleft is recognized by the: -
answer-CD4 or CD8 molecules
The edema occurring in the inflammatory process is the result of all the following factors
EXCEPT: - answer-neural impulse by the sympathetic system and vasoconstriction
Toll-Like Receptors (TLR): - answer-recognize pathogen-associated molecular patterns (PAMPs)
on selective microorganisms
The initiation of T cell responses requires multiple receptors on the T cells recognizing ligands
on APCs. The T cell receptor transduction molecule(s) is(are) conducted by: - answer-CD3 and ζ
molecules
Which of the following is considered a primary lymphoid organ? - answer-thymus
1
,Immediate activation of the B lymphocytes following contact with the antigen involves all of the
following molecules EXCEPT: - answer-MHC class II molecules
Immunologic memory refers to: - answer-changes in adaptive immune responses with
subsequent encounters with antigen
Both, naive mature effector T lymphocytes migrate differently in their lives. Naive T cells
express which adhesion molecule to mediate their migration into lymph nodes through
specialized vessels called high endothelial venues (HEVs)? - answer-L-selectin
The main consequences of complement activation are all of the following EXCEPT: - answer-
producing 2nd signal for macrophage activation
'Langerhans Cells' which play a role in the immune system are: - answer-dendritic cells located
mainly in the epidermis
All of the following cells results in the germinal center reaction of the follicles (B lymphocyte
zone) EXCEPT: - answer-short-lived plasma cells
The antigen recognition on the T cells is mediated by: - answer-the Variable (v) regions of α and
β chains
The T-cell receptor: - answer-recognizes antigen fragments via the α and β chains
According to the clonal selection hypothesis, which of the following is CORRECT? - answer-
Clones of lymphocytes specific for antigens develop prior to exposure to the antigens
Which of the following best describes the T-dependent antibody response? - answer-IT is the
2
, response of follicular B lymphocytes to a protein antigen and characterized by isotope-
switched, high affinity antibodies; memory B cells, long lived plasma cells
MHC class II molecules contain: - answer-One α chain and one β chain
The inflammatory cytokines will cause Langerhans cells in the epidermis to perform all of the
following EXCEPT: - answer-antigen presentation to the T cells in the follicles of the lymph
nodes
The phases and order of the specific or acquired immune responses are: - answer-recognition
phase; activation phase; effector phase; homeostasis phase; memory phase
A naive CD4+ T cell may differentiate into subsets that produce different cytokines that recruit
and activate different cell types. The IFN-γ is produced mainly by: - answer-CD4+ T cell TH1
subset
TH1 subset effector cells that aid in cell mediated immune response activate the macrophage
and B lymphocytes by: - answer-CD40L-CD40 interaction and IFN-γ
The diversity of antigen receptors produced by the use of different combinations of V, D, and J
gene segments in different clones of lymphocytes is the result of: - answer-both combinatorial
diversity and junctional diversity
All of the following statements about the B-cell antigen receptor are true EXCEPT: - answer-
recognizes antigen fragments via the α and β chains
A standard treatment of animal bite victims, when there is a possibility that the animal was
infected with rabies virus, is administration of human immunoglobulin preparations containing
anti-rabies virus antibodies. Which type of immunity would be established by this treatment? -
3
6th Edition by Linda E. Miller
The germinal centers found in the cortical region of lymph nodes and the peripheral region of
splenic periarteriolar lymphatic tissue: - answer-contains large populations of B lymphocytes
and plasma cells
Balance between TH1 and TH2 cell activation determines outcome of intracellular infections.
Thus, in case of Mycobacterium leprae infection: - answer-tuberculoid leprosy will occur in
patients with a prominent TH1 response
The initiation of T cell responses requires multiple receptors on the T cells recognizing ligands
on APCs. The MHC molecule located around the peptide-binding cleft is recognized by the: -
answer-CD4 or CD8 molecules
The edema occurring in the inflammatory process is the result of all the following factors
EXCEPT: - answer-neural impulse by the sympathetic system and vasoconstriction
Toll-Like Receptors (TLR): - answer-recognize pathogen-associated molecular patterns (PAMPs)
on selective microorganisms
The initiation of T cell responses requires multiple receptors on the T cells recognizing ligands
on APCs. The T cell receptor transduction molecule(s) is(are) conducted by: - answer-CD3 and ζ
molecules
Which of the following is considered a primary lymphoid organ? - answer-thymus
1
,Immediate activation of the B lymphocytes following contact with the antigen involves all of the
following molecules EXCEPT: - answer-MHC class II molecules
Immunologic memory refers to: - answer-changes in adaptive immune responses with
subsequent encounters with antigen
Both, naive mature effector T lymphocytes migrate differently in their lives. Naive T cells
express which adhesion molecule to mediate their migration into lymph nodes through
specialized vessels called high endothelial venues (HEVs)? - answer-L-selectin
The main consequences of complement activation are all of the following EXCEPT: - answer-
producing 2nd signal for macrophage activation
'Langerhans Cells' which play a role in the immune system are: - answer-dendritic cells located
mainly in the epidermis
All of the following cells results in the germinal center reaction of the follicles (B lymphocyte
zone) EXCEPT: - answer-short-lived plasma cells
The antigen recognition on the T cells is mediated by: - answer-the Variable (v) regions of α and
β chains
The T-cell receptor: - answer-recognizes antigen fragments via the α and β chains
According to the clonal selection hypothesis, which of the following is CORRECT? - answer-
Clones of lymphocytes specific for antigens develop prior to exposure to the antigens
Which of the following best describes the T-dependent antibody response? - answer-IT is the
2
, response of follicular B lymphocytes to a protein antigen and characterized by isotope-
switched, high affinity antibodies; memory B cells, long lived plasma cells
MHC class II molecules contain: - answer-One α chain and one β chain
The inflammatory cytokines will cause Langerhans cells in the epidermis to perform all of the
following EXCEPT: - answer-antigen presentation to the T cells in the follicles of the lymph
nodes
The phases and order of the specific or acquired immune responses are: - answer-recognition
phase; activation phase; effector phase; homeostasis phase; memory phase
A naive CD4+ T cell may differentiate into subsets that produce different cytokines that recruit
and activate different cell types. The IFN-γ is produced mainly by: - answer-CD4+ T cell TH1
subset
TH1 subset effector cells that aid in cell mediated immune response activate the macrophage
and B lymphocytes by: - answer-CD40L-CD40 interaction and IFN-γ
The diversity of antigen receptors produced by the use of different combinations of V, D, and J
gene segments in different clones of lymphocytes is the result of: - answer-both combinatorial
diversity and junctional diversity
All of the following statements about the B-cell antigen receptor are true EXCEPT: - answer-
recognizes antigen fragments via the α and β chains
A standard treatment of animal bite victims, when there is a possibility that the animal was
infected with rabies virus, is administration of human immunoglobulin preparations containing
anti-rabies virus antibodies. Which type of immunity would be established by this treatment? -
3
