Molecular Cell Biology – lecture summary

Lodish • Berk • Kaiser • Krieger • Scott • Bretscher •Ploegh • Matsudaira
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• MOLECULARCELL fk




BIOLOGY fk




• SIXTH EDITION fk




• CHAPTER 3 fk




• Protein Structure and Function
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© 2008 W. H. Freeman and Company
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, Human
signaling
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proteinkeapl
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Ribbondiagram
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,Conformations Functional classes: fk




fk Structural proteins fk



fk Structural proteins fk




fk Scaffold protein
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fk Transport proteins
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fk Transport protein fk




fk Regulatoryproteins fk




Regulatoryprotein
Motor proteins
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fk enzymes



Different conformation = different function
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, Hierarchicalstructureofproteins kf kf kf




Proteinsaresingle,unbranchedchains ofaminoacidmonomers
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There are 20 different amino acids; All amino acids have the same general structure
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but the side chain (R group) of each is different
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A protein’s amino acid sequence determines its three-dimensional structure
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(conformation)
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Inturn,aprotein’sstructuredeterminesthefunctionofthatprotein
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