Zoology 523 UW-Madison Exam 2 ACTUAL UPDATED Questions and CORRECT
Answers
C
Terms in this set (105)
What are examples of neurotransmitters systems that Glutamate and GABA
have widespread production in and action upon the
CNS?
Catecholamines dopamine, norepinephrine, epinephrine
What is known about dopamine signaling in terms of what Dopamine is often linked to 'wanting' related to addiction and reward.
functions it has, where it is produced and where it acts in Localized to few brain regions and fairly focused action with discrete target
the CNS? Are there any diseases associated with Substantia nigra, ventral tegmental area, and hypothalamus of the brain
dopamine dysfunction? Parkinson's disease
What are examples of neurotransmitter systems that are Serotonin, dopamine, and acetylcholine are produced in discrete regions.
produced in discrete regions? Why is it useful to have No, some are produced in various parts of the CNS and have varying release
know the origin and sites of action of different points.
neurotransmitter system? If you know where a
neurotransmitter is produced in the CNS (that is, where
the cell bodies are), does this necessarily tell you where it
is being released?s?
From what amino acid is dopamine made? What is Amino acid phenylalanine
tyrosine hydroxylase and why can that be used to help Tyrosine Hydroxylase used as marker because it is one step before dopamine
identify dopamine producing neurons? production
If someone tells you a certain neurotransmitter is
released into a specific region, what should you expect
to find in that region?
What is known about serotonin in terms of function and Mood and response to antidepressants (SSRIs) and ecstasy
where serotonin containing neurons are found and where Restricted to discrete clusters or groups of cells located along the midline of the
the act? brainstem
Their axons innervate nearly every area of the CNS
Few regions, wide spread action
What amino acid is serotonin derived from and what Tryptophan
enzyme breaks it down? Broken down by MAO-A
, What is known about acetylcholine (ACh) in terms of Small neurotransmitter
function and where is it produced and where does it act Memory, reward, Alzheimers, Parkinsons
in the CNS? Released by nerve cells to send signals to other cells, such as neurons, muscle
cells and gland cells
Only in few regions, released in many
How is ACh produced and how is it broken down? Where Acetyl CoA + Choline -ChAT-> ACh
is ACh packaged into presynaptic vesicles? In the cell Broken down by AChE
body or presynaptic terminal? Packaged in presynaptic terminal
What is the relationship of glutamate to GABA and how is Glutamate -GAD-> GABA
GABA made?
What is known about GABA in terms of overall function Primary inhibitory neurotransmitter
and sites of production and release? Widespread production and vesicles
Alcohol and Anxiolytics target pathway
Packaged into vesicles in presynaptic terminal
Why does knowing the location of expression of GAD1
and GAD2 help us determine GABA production?
Where in the neuron are GABA and glutamate packaged Packaged in presynaptic terminals
into vesicles and how are both of these transported back Glutamate neuron reuptakes glutamate
into the presynaptic terminal? Do small molecules GABA at the synapse is terminated by reuptake into both presynaptic nerve
generally get packaged in the presynaptic terminal? terminals and surrounding glial cells
Glutamate packaged into vesicles and harder to have markers
What is known about glutamate in terms of overall primarily excitatory
function and sites of production and release? memory
released by nerve cells
sends signals between nerve cells
Why is knowing what proteins are involved in glutamate
transport useful in identifying which neurons use
glutamate as a neurotransmitter?
What is known about the function of 'endogenous Neuropeptide
opioids' and what type of neurotransmitter is enkephalin Risky behavior
(amine or neuropeptide)? Why is the finding of opioid Many CNS regions
receptors in reward regions of the CNS consistent with Opioids act on these receptors are highly addictive
the known function of endogenous opioids?
What are endocannabinoids, why are they unusual Pain response, mood, reward, weed
compared to other neurotransmitters and is there Wide spread production and action
production and action widespread or only in a few THC mimics 2 natural fatty acid neurotransmitters
regions? - anandamide
- 2-AG
Answers
C
Terms in this set (105)
What are examples of neurotransmitters systems that Glutamate and GABA
have widespread production in and action upon the
CNS?
Catecholamines dopamine, norepinephrine, epinephrine
What is known about dopamine signaling in terms of what Dopamine is often linked to 'wanting' related to addiction and reward.
functions it has, where it is produced and where it acts in Localized to few brain regions and fairly focused action with discrete target
the CNS? Are there any diseases associated with Substantia nigra, ventral tegmental area, and hypothalamus of the brain
dopamine dysfunction? Parkinson's disease
What are examples of neurotransmitter systems that are Serotonin, dopamine, and acetylcholine are produced in discrete regions.
produced in discrete regions? Why is it useful to have No, some are produced in various parts of the CNS and have varying release
know the origin and sites of action of different points.
neurotransmitter system? If you know where a
neurotransmitter is produced in the CNS (that is, where
the cell bodies are), does this necessarily tell you where it
is being released?s?
From what amino acid is dopamine made? What is Amino acid phenylalanine
tyrosine hydroxylase and why can that be used to help Tyrosine Hydroxylase used as marker because it is one step before dopamine
identify dopamine producing neurons? production
If someone tells you a certain neurotransmitter is
released into a specific region, what should you expect
to find in that region?
What is known about serotonin in terms of function and Mood and response to antidepressants (SSRIs) and ecstasy
where serotonin containing neurons are found and where Restricted to discrete clusters or groups of cells located along the midline of the
the act? brainstem
Their axons innervate nearly every area of the CNS
Few regions, wide spread action
What amino acid is serotonin derived from and what Tryptophan
enzyme breaks it down? Broken down by MAO-A
, What is known about acetylcholine (ACh) in terms of Small neurotransmitter
function and where is it produced and where does it act Memory, reward, Alzheimers, Parkinsons
in the CNS? Released by nerve cells to send signals to other cells, such as neurons, muscle
cells and gland cells
Only in few regions, released in many
How is ACh produced and how is it broken down? Where Acetyl CoA + Choline -ChAT-> ACh
is ACh packaged into presynaptic vesicles? In the cell Broken down by AChE
body or presynaptic terminal? Packaged in presynaptic terminal
What is the relationship of glutamate to GABA and how is Glutamate -GAD-> GABA
GABA made?
What is known about GABA in terms of overall function Primary inhibitory neurotransmitter
and sites of production and release? Widespread production and vesicles
Alcohol and Anxiolytics target pathway
Packaged into vesicles in presynaptic terminal
Why does knowing the location of expression of GAD1
and GAD2 help us determine GABA production?
Where in the neuron are GABA and glutamate packaged Packaged in presynaptic terminals
into vesicles and how are both of these transported back Glutamate neuron reuptakes glutamate
into the presynaptic terminal? Do small molecules GABA at the synapse is terminated by reuptake into both presynaptic nerve
generally get packaged in the presynaptic terminal? terminals and surrounding glial cells
Glutamate packaged into vesicles and harder to have markers
What is known about glutamate in terms of overall primarily excitatory
function and sites of production and release? memory
released by nerve cells
sends signals between nerve cells
Why is knowing what proteins are involved in glutamate
transport useful in identifying which neurons use
glutamate as a neurotransmitter?
What is known about the function of 'endogenous Neuropeptide
opioids' and what type of neurotransmitter is enkephalin Risky behavior
(amine or neuropeptide)? Why is the finding of opioid Many CNS regions
receptors in reward regions of the CNS consistent with Opioids act on these receptors are highly addictive
the known function of endogenous opioids?
What are endocannabinoids, why are they unusual Pain response, mood, reward, weed
compared to other neurotransmitters and is there Wide spread production and action
production and action widespread or only in a few THC mimics 2 natural fatty acid neurotransmitters
regions? - anandamide
- 2-AG
