COMSAE ACTUAL EXAM QUESTIONS AND
COMPLETE STUDY GUIDE 2026
▶ a nonsteroidal competitive inhibitor of androgens at the testosterone
receptor
used in prostate carcinoma.. Answer: Flutamide
▶ inhibits steroid binding
used to prevent hirsutism.
side effects of gynecomastia and amenorrhea
used in the treatment of PCOS. Answer: spironolactone
▶ alpha 1 antagonist used to treat BPH by inhibiting smooth muscle
contraction.. Answer: Tamsulosin
▶ bind progesterone receptors
reduce growth and increase in vascularization of endometrium
used clinically in oral contraceptives and in the treatment of endometrial
cancer and abnormal uterine bleeding.. Answer: Progestins
▶ a beta 2 agonist that relaxes the uterus reduces premature uterine
contractions.. Answer: Terbutaline
▶ competitive inhibitor of progestins at progesterone receptors
used clinically to terminate pregnancy
administered with misoprostol (PGE1). Answer: mifepristone (RU - 486)
, ▶ Aromatase inhibitors used in postmenopausal women with breast
cancer.. Answer: Anastrozole, Letrozole, Exemestane
▶ used for relief or prevention of menopausal symptoms (e.g. hot flashes,
vaginal atrophy) and osteoporosis (increased estrogen, decreased
osteoclast activity)
unopposed estrogen replacement therapy (ERT) increases the risk of
endometrial cancer so progesterone is added.
Possible increase in CV risk.. Answer: Hormone Replacement Therapy
▶ SERM antagonist on breast tissue
used to treat and prevent recurrence of ER-Positive breast cancer.
can cause?. Answer: Tamoxifen
Fibroids
▶ SERM - Agonist on bone
reduces resorption of bone
used to treat osteoporosis.. Answer: Raloxifene
▶ SERM - Partial agonist at estrogen receptors in hypothalamus.
prevents normal feedback inhibition and increased release of LH and FSH
from pituitary = stimulates ovaries
Used to treat infertility and PCOS
may cause hot flashes, ovarian enlargement, multiple simultaneous
pregnancies and visual disturbances.. Answer: Clomiphene
▶ synthetic androgen that acts as partial agonist at androgen receptors
used clinically in endometriosis and hereditary angioedema.
COMPLETE STUDY GUIDE 2026
▶ a nonsteroidal competitive inhibitor of androgens at the testosterone
receptor
used in prostate carcinoma.. Answer: Flutamide
▶ inhibits steroid binding
used to prevent hirsutism.
side effects of gynecomastia and amenorrhea
used in the treatment of PCOS. Answer: spironolactone
▶ alpha 1 antagonist used to treat BPH by inhibiting smooth muscle
contraction.. Answer: Tamsulosin
▶ bind progesterone receptors
reduce growth and increase in vascularization of endometrium
used clinically in oral contraceptives and in the treatment of endometrial
cancer and abnormal uterine bleeding.. Answer: Progestins
▶ a beta 2 agonist that relaxes the uterus reduces premature uterine
contractions.. Answer: Terbutaline
▶ competitive inhibitor of progestins at progesterone receptors
used clinically to terminate pregnancy
administered with misoprostol (PGE1). Answer: mifepristone (RU - 486)
, ▶ Aromatase inhibitors used in postmenopausal women with breast
cancer.. Answer: Anastrozole, Letrozole, Exemestane
▶ used for relief or prevention of menopausal symptoms (e.g. hot flashes,
vaginal atrophy) and osteoporosis (increased estrogen, decreased
osteoclast activity)
unopposed estrogen replacement therapy (ERT) increases the risk of
endometrial cancer so progesterone is added.
Possible increase in CV risk.. Answer: Hormone Replacement Therapy
▶ SERM antagonist on breast tissue
used to treat and prevent recurrence of ER-Positive breast cancer.
can cause?. Answer: Tamoxifen
Fibroids
▶ SERM - Agonist on bone
reduces resorption of bone
used to treat osteoporosis.. Answer: Raloxifene
▶ SERM - Partial agonist at estrogen receptors in hypothalamus.
prevents normal feedback inhibition and increased release of LH and FSH
from pituitary = stimulates ovaries
Used to treat infertility and PCOS
may cause hot flashes, ovarian enlargement, multiple simultaneous
pregnancies and visual disturbances.. Answer: Clomiphene
▶ synthetic androgen that acts as partial agonist at androgen receptors
used clinically in endometriosis and hereditary angioedema.
